Peste des petits ruminants virus (PPRV) is a highly contagious and infectious virus of small ruminants and camel and is endemic in several African, Middle Eastern and Asian countries. Recently, intensive efforts have been made to develop and produce potent vaccines and efficient diagnostic kits, and to understand the molecular epidemiology in endemic countries. These efforts, along with success story of rinderpest, have established baseline for the control of PPRV. Efforts for effective control and subsequent eradication include focused vaccinations in highrisk small ruminants followed by carpet vaccination, understanding socio-economic and culture situation of the small ruminants holder, established infrastructure to cope emergence of disease, and co-operation in countries where disease is endemic with essential involvement of international organizations. In this chapter, all these requirements and deliverables are comprehensively discussed.