Home > Research > Publications & Outputs > The International Society for Bipolar Disorders...

Electronic data

  • ISBD_Pediatric Task Force revised manuscript_submitted

    Rights statement: This is the peer reviewed version of the following article: Goldstein BI, Birmaher B, Carlson GA, et al. The International Society for Bipolar Disorders Task Force report on pediatric bipolar disorder: Knowledge to date and directions for future research. Bipolar Disord. 2017;19:524–543. https://doi.org/10.1111/bdi.12556 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/bdi.12556/abstract This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

    Accepted author manuscript, 696 KB, PDF-document

    Available under license: CC BY-NC: Creative Commons Attribution-NonCommercial 4.0 International License

Links

Text available via DOI:

View graph of relations

The International Society for Bipolar Disorders Task Force Report on Pediatric Bipolar Disorder: Knowledge to Date and Directions for Future Research

Research output: Contribution to journalJournal article

Published
  • Benjamin Goldstein
  • Boris Birmaher
  • Gabrielle Carlson
  • Melissa DelBello
  • Robert Findling
  • Mary Fristad
  • Robert Kowatch
  • David Miklowitz
  • Fabiano Nery
  • Guillermo Daniel Perez Algorta
  • Anna Van Meter
  • Cristian Zeni
  • Christoph Correll
  • Hyo-Won Kim
  • Janet Wozniak
  • Kiki Chang
  • Manon Hillegers
  • Eric A. Youngstrom
Close
<mark>Journal publication date</mark>11/2017
<mark>Journal</mark>Bipolar Disorders
Issue number7
Volume19
Number of pages20
Pages (from-to)524-543
Publication statusPublished
Early online date25/09/17
Original languageEnglish

Abstract

Objectives: Over the past two decades there has been tremendous growth in research regarding bipolar disorder (BD) among children and adolescents (i.e., pediatric BD; PBD). The primary purpose of this article is to distill the extant literature, dispel myths or exaggerated assertions in
the field, and disseminate clinically relevant findings.

Methods: An international group of experts completed a selective review of the literature, emphasizing areas of consensus, identifying limitations and gaps in the literature, and highlighting future directions to mitigate these gaps.

Results: Substantial, and increasingly international, research has accumulated regarding the phenomenology, differential diagnosis, course, treatment, and neurobiology of PBD. Prior division around the role of irritability and of screening tools in diagnosis has largely abated. Goldstandard
pharmacological trials inform treatment of manic/mixed episodes, whereas fewer data address bipolar depression and maintenance/continuation treatment. Adjunctive psychosocial treatment
provides a forum for psychoeducation and targets primarily depressive symptoms. Numerous neurocognitive and neuroimaging studies, and increasing peripheral biomarker studies, largely converge with prior findings from adults with BD.

Conclusions: As data have accumulated and controversy has dissipated, the field has moved past existential questions about PBD toward defining and pursuing pressing clinical and scientific priorities that remain. The overall body of evidence supports the position that perceptions about
marked international (U.S. versus elsewhere) and developmental (pediatric vs. adult) differences have been overstated, although additional research on these topics is warranted. Traction toward improved outcomes will be supported by continued emphasis on pathophysiology and novel
therapeutics.

Bibliographic note

This is the peer reviewed version of the following article:Goldstein BI, Birmaher B, Carlson GA, et al. The International Society for Bipolar Disorders Task Force report on pediatric bipolar disorder: Knowledge to date and directions for future research. Bipolar Disord. 2017;19:524–543. https://doi.org/10.1111/bdi.12556 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/bdi.12556/abstract This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.