Rights statement: This is the peer reviewed version of the following article: Goldstein BI, Birmaher B, Carlson GA, et al. The International Society for Bipolar Disorders Task Force report on pediatric bipolar disorder: Knowledge to date and directions for future research. Bipolar Disord. 2017;19:524–543. https://doi.org/10.1111/bdi.12556 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/bdi.12556/abstract This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
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Final published version
Licence: CC BY-NC: Creative Commons Attribution-NonCommercial 4.0 International License
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - The International Society for Bipolar Disorders Task Force Report on Pediatric Bipolar Disorder
T2 - Knowledge to Date and Directions for Future Research
AU - Goldstein, Benjamin
AU - Birmaher, Boris
AU - Carlson, Gabrielle
AU - DelBello, Melissa
AU - Findling, Robert
AU - Fristad, Mary
AU - Kowatch, Robert
AU - Miklowitz, David
AU - Nery, Fabiano
AU - Perez Algorta, Guillermo Daniel
AU - Van Meter, Anna
AU - Zeni, Cristian
AU - Correll, Christoph
AU - Kim, Hyo-Won
AU - Wozniak, Janet
AU - Chang, Kiki
AU - Hillegers, Manon
AU - Youngstrom, Eric A.
N1 - This is the peer reviewed version of the following article:Goldstein BI, Birmaher B, Carlson GA, et al. The International Society for Bipolar Disorders Task Force report on pediatric bipolar disorder: Knowledge to date and directions for future research. Bipolar Disord. 2017;19:524–543. https://doi.org/10.1111/bdi.12556 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/bdi.12556/abstract This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
PY - 2017/11
Y1 - 2017/11
N2 - Objectives: Over the past two decades there has been tremendous growth in research regarding bipolar disorder (BD) among children and adolescents (i.e., pediatric BD; PBD). The primary purpose of this article is to distill the extant literature, dispel myths or exaggerated assertions inthe field, and disseminate clinically relevant findings.Methods: An international group of experts completed a selective review of the literature, emphasizing areas of consensus, identifying limitations and gaps in the literature, and highlighting future directions to mitigate these gaps.Results: Substantial, and increasingly international, research has accumulated regarding the phenomenology, differential diagnosis, course, treatment, and neurobiology of PBD. Prior division around the role of irritability and of screening tools in diagnosis has largely abated. Goldstandardpharmacological trials inform treatment of manic/mixed episodes, whereas fewer data address bipolar depression and maintenance/continuation treatment. Adjunctive psychosocial treatmentprovides a forum for psychoeducation and targets primarily depressive symptoms. Numerous neurocognitive and neuroimaging studies, and increasing peripheral biomarker studies, largely converge with prior findings from adults with BD.Conclusions: As data have accumulated and controversy has dissipated, the field has moved past existential questions about PBD toward defining and pursuing pressing clinical and scientific priorities that remain. The overall body of evidence supports the position that perceptions aboutmarked international (U.S. versus elsewhere) and developmental (pediatric vs. adult) differences have been overstated, although additional research on these topics is warranted. Traction toward improved outcomes will be supported by continued emphasis on pathophysiology and noveltherapeutics.
AB - Objectives: Over the past two decades there has been tremendous growth in research regarding bipolar disorder (BD) among children and adolescents (i.e., pediatric BD; PBD). The primary purpose of this article is to distill the extant literature, dispel myths or exaggerated assertions inthe field, and disseminate clinically relevant findings.Methods: An international group of experts completed a selective review of the literature, emphasizing areas of consensus, identifying limitations and gaps in the literature, and highlighting future directions to mitigate these gaps.Results: Substantial, and increasingly international, research has accumulated regarding the phenomenology, differential diagnosis, course, treatment, and neurobiology of PBD. Prior division around the role of irritability and of screening tools in diagnosis has largely abated. Goldstandardpharmacological trials inform treatment of manic/mixed episodes, whereas fewer data address bipolar depression and maintenance/continuation treatment. Adjunctive psychosocial treatmentprovides a forum for psychoeducation and targets primarily depressive symptoms. Numerous neurocognitive and neuroimaging studies, and increasing peripheral biomarker studies, largely converge with prior findings from adults with BD.Conclusions: As data have accumulated and controversy has dissipated, the field has moved past existential questions about PBD toward defining and pursuing pressing clinical and scientific priorities that remain. The overall body of evidence supports the position that perceptions aboutmarked international (U.S. versus elsewhere) and developmental (pediatric vs. adult) differences have been overstated, although additional research on these topics is warranted. Traction toward improved outcomes will be supported by continued emphasis on pathophysiology and noveltherapeutics.
U2 - 10.1111/bdi.12556
DO - 10.1111/bdi.12556
M3 - Journal article
VL - 19
SP - 524
EP - 543
JO - Bipolar Disorders
JF - Bipolar Disorders
SN - 1398-5647
IS - 7
ER -