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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids
AU - Rudd, Timothy R.
AU - Skidmore, Mark A.
AU - Guimond, Scott E.
AU - Holman, Joseph
AU - Turnbull, Jeremy E.
AU - Lauder, Robert M.
AU - Fernig, David G.
AU - Yates, Edwin A.
PY - 2009/11
Y1 - 2009/11
N2 - The ultraviolet circular dichroism (CD) spectra of commercial low-molecular-weight heparins, heparinoids and other anticoagulant preparations have been recorded between 180 and 260 nm. Principal component analysis of the spectra allowed their differentiation into a number of groups related to the means of their production reflecting the structural changes introduced by each process. The findings suggest that CD provides a complementary technique for the rapid analysis of heparin preparations.
AB - The ultraviolet circular dichroism (CD) spectra of commercial low-molecular-weight heparins, heparinoids and other anticoagulant preparations have been recorded between 180 and 260 nm. Principal component analysis of the spectra allowed their differentiation into a number of groups related to the means of their production reflecting the structural changes introduced by each process. The findings suggest that CD provides a complementary technique for the rapid analysis of heparin preparations.
KW - Circular dichroism
KW - low-molecular-weight heparin
KW - heparinoids
KW - principal component analysis
KW - quality control
KW - ADVERSE CLINICAL EVENTS
KW - OVERSULFATED CHONDROITIN SULFATE
KW - MAGNETIC-RESONANCE-SPECTROSCOPY
KW - BEER
U2 - 10.1160/TH08-12-0797
DO - 10.1160/TH08-12-0797
M3 - Journal article
VL - 102
SP - 874
EP - 878
JO - Thrombosis and Haemostasis
JF - Thrombosis and Haemostasis
SN - 0340-6245
IS - 5
T2 - 16th Heparin Symposium
Y2 - 1 January 2008
ER -