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The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids. / Rudd, Timothy R.; Skidmore, Mark A.; Guimond, Scott E. et al.
In: Thrombosis and Haemostasis, Vol. 102, No. 5, 11.2009, p. 874-878.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Rudd, TR, Skidmore, MA, Guimond, SE, Holman, J, Turnbull, JE, Lauder, RM, Fernig, DG & Yates, EA 2009, 'The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids', Thrombosis and Haemostasis, vol. 102, no. 5, pp. 874-878. https://doi.org/10.1160/TH08-12-0797

APA

Rudd, T. R., Skidmore, M. A., Guimond, S. E., Holman, J., Turnbull, J. E., Lauder, R. M., Fernig, D. G., & Yates, E. A. (2009). The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids. Thrombosis and Haemostasis, 102(5), 874-878. https://doi.org/10.1160/TH08-12-0797

Vancouver

Rudd TR, Skidmore MA, Guimond SE, Holman J, Turnbull JE, Lauder RM et al. The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids. Thrombosis and Haemostasis. 2009 Nov;102(5):874-878. doi: 10.1160/TH08-12-0797

Author

Rudd, Timothy R. ; Skidmore, Mark A. ; Guimond, Scott E. et al. / The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids. In: Thrombosis and Haemostasis. 2009 ; Vol. 102, No. 5. pp. 874-878.

Bibtex

@article{a84a3d6ac4e842d2ab26bbc6ac27909a,
title = "The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids",
abstract = "The ultraviolet circular dichroism (CD) spectra of commercial low-molecular-weight heparins, heparinoids and other anticoagulant preparations have been recorded between 180 and 260 nm. Principal component analysis of the spectra allowed their differentiation into a number of groups related to the means of their production reflecting the structural changes introduced by each process. The findings suggest that CD provides a complementary technique for the rapid analysis of heparin preparations.",
keywords = "Circular dichroism, low-molecular-weight heparin, heparinoids, principal component analysis, quality control, ADVERSE CLINICAL EVENTS, OVERSULFATED CHONDROITIN SULFATE, MAGNETIC-RESONANCE-SPECTROSCOPY, BEER",
author = "Rudd, {Timothy R.} and Skidmore, {Mark A.} and Guimond, {Scott E.} and Joseph Holman and Turnbull, {Jeremy E.} and Lauder, {Robert M.} and Fernig, {David G.} and Yates, {Edwin A.}",
year = "2009",
month = nov,
doi = "10.1160/TH08-12-0797",
language = "English",
volume = "102",
pages = "874--878",
journal = "Thrombosis and Haemostasis",
issn = "0340-6245",
publisher = "SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN",
number = "5",
note = "16th Heparin Symposium ; Conference date: 01-01-2008",

}

RIS

TY - JOUR

T1 - The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids

AU - Rudd, Timothy R.

AU - Skidmore, Mark A.

AU - Guimond, Scott E.

AU - Holman, Joseph

AU - Turnbull, Jeremy E.

AU - Lauder, Robert M.

AU - Fernig, David G.

AU - Yates, Edwin A.

PY - 2009/11

Y1 - 2009/11

N2 - The ultraviolet circular dichroism (CD) spectra of commercial low-molecular-weight heparins, heparinoids and other anticoagulant preparations have been recorded between 180 and 260 nm. Principal component analysis of the spectra allowed their differentiation into a number of groups related to the means of their production reflecting the structural changes introduced by each process. The findings suggest that CD provides a complementary technique for the rapid analysis of heparin preparations.

AB - The ultraviolet circular dichroism (CD) spectra of commercial low-molecular-weight heparins, heparinoids and other anticoagulant preparations have been recorded between 180 and 260 nm. Principal component analysis of the spectra allowed their differentiation into a number of groups related to the means of their production reflecting the structural changes introduced by each process. The findings suggest that CD provides a complementary technique for the rapid analysis of heparin preparations.

KW - Circular dichroism

KW - low-molecular-weight heparin

KW - heparinoids

KW - principal component analysis

KW - quality control

KW - ADVERSE CLINICAL EVENTS

KW - OVERSULFATED CHONDROITIN SULFATE

KW - MAGNETIC-RESONANCE-SPECTROSCOPY

KW - BEER

U2 - 10.1160/TH08-12-0797

DO - 10.1160/TH08-12-0797

M3 - Journal article

VL - 102

SP - 874

EP - 878

JO - Thrombosis and Haemostasis

JF - Thrombosis and Haemostasis

SN - 0340-6245

IS - 5

T2 - 16th Heparin Symposium

Y2 - 1 January 2008

ER -