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The stationary distribution of allele frequencies when selection acts at unlinked loci.

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The stationary distribution of allele frequencies when selection acts at unlinked loci. / Fearnhead, Paul.
In: Theoretical Population Biology, Vol. 70, No. 3, 11.2006, p. 376-386.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Fearnhead, P 2006, 'The stationary distribution of allele frequencies when selection acts at unlinked loci.', Theoretical Population Biology, vol. 70, no. 3, pp. 376-386. https://doi.org/10.1016/j.tpb.2006.02.001

APA

Fearnhead, P. (2006). The stationary distribution of allele frequencies when selection acts at unlinked loci. Theoretical Population Biology, 70(3), 376-386. https://doi.org/10.1016/j.tpb.2006.02.001

Vancouver

Fearnhead P. The stationary distribution of allele frequencies when selection acts at unlinked loci. Theoretical Population Biology. 2006 Nov;70(3):376-386. doi: 10.1016/j.tpb.2006.02.001

Author

Fearnhead, Paul. / The stationary distribution of allele frequencies when selection acts at unlinked loci. In: Theoretical Population Biology. 2006 ; Vol. 70, No. 3. pp. 376-386.

Bibtex

@article{ee1faae4122349f7bea2286d7cfc9fdf,
title = "The stationary distribution of allele frequencies when selection acts at unlinked loci.",
abstract = "We consider population genetics models where selection acts at a set of unlinked loci. It is known that if the fitness of an individual is multiplicative across loci, then these loci are independent. We consider general selection models, but assume parent-independent mutation at each locus. For such a model, the joint stationary distribution of allele frequencies is proportional to the stationary distribution under neutrality multiplied by a known function of the mean fitness of the population. We further show how knowledge of this stationary distribution enables direct simulation of the genealogy of a sample at a single-locus. For a specific selection model appropriate for complex disease genes, we use simulation to determine what features of the genealogy differ between our general selection model and a multiplicative model.",
author = "Paul Fearnhead",
year = "2006",
month = nov,
doi = "10.1016/j.tpb.2006.02.001",
language = "English",
volume = "70",
pages = "376--386",
journal = "Theoretical Population Biology",
issn = "1096-0325",
publisher = "Academic Press Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - The stationary distribution of allele frequencies when selection acts at unlinked loci.

AU - Fearnhead, Paul

PY - 2006/11

Y1 - 2006/11

N2 - We consider population genetics models where selection acts at a set of unlinked loci. It is known that if the fitness of an individual is multiplicative across loci, then these loci are independent. We consider general selection models, but assume parent-independent mutation at each locus. For such a model, the joint stationary distribution of allele frequencies is proportional to the stationary distribution under neutrality multiplied by a known function of the mean fitness of the population. We further show how knowledge of this stationary distribution enables direct simulation of the genealogy of a sample at a single-locus. For a specific selection model appropriate for complex disease genes, we use simulation to determine what features of the genealogy differ between our general selection model and a multiplicative model.

AB - We consider population genetics models where selection acts at a set of unlinked loci. It is known that if the fitness of an individual is multiplicative across loci, then these loci are independent. We consider general selection models, but assume parent-independent mutation at each locus. For such a model, the joint stationary distribution of allele frequencies is proportional to the stationary distribution under neutrality multiplied by a known function of the mean fitness of the population. We further show how knowledge of this stationary distribution enables direct simulation of the genealogy of a sample at a single-locus. For a specific selection model appropriate for complex disease genes, we use simulation to determine what features of the genealogy differ between our general selection model and a multiplicative model.

U2 - 10.1016/j.tpb.2006.02.001

DO - 10.1016/j.tpb.2006.02.001

M3 - Journal article

VL - 70

SP - 376

EP - 386

JO - Theoretical Population Biology

JF - Theoretical Population Biology

SN - 1096-0325

IS - 3

ER -