The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain

Biomedical and Life Sciences

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https://doi.org/10.1016/j.ejphar.2012.12.012
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Keywords

Animals, Anti-Inflammatory Agents, Astrocytes, Body Weight, Brain, Cytokines, Diabetes Mellitus, Type 2, Eating, Glucagon-Like Peptide 1, Inflammation, Male, Mice, Mice, Inbred C57BL, Microglia, Nitric Oxide Synthase Type II, Nitrites, Radiation Injuries, Experimental

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The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain. / Parthsarathy, Vadivel; Hölscher, Christian.
In: European Journal of Pharmacology, Vol. 700, No. 1-3, 30.01.2013, p. 42-50.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Bibtex

@article{5c8f4884c698431a9d0e92c0de2acbd9,

title = "The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain",

abstract = "Chronic inflammation in the brain is found in a range of neurodegenerative diseases such as Parkinson's or Alzheimer's disease. We have recently shown that analogues of the glucagon-like polypeptide 1 (GLP-1) such as liraglutide have potent neuroprotective properties in a mouse model of Alzheimer's disease. We also found a reduction of activated microglia in the brain. This finding suggests that GLP-1 analogues such as liraglutide have anti-inflammatory properties. To further characterise this property, we tested the effects of liraglutide on the chronic inflammation response induced by exposure of the brain to 6 Gy (X-ray). Animals were injected i.p. with 25 nmol/kg once daily for 30 days. Brains were analysed for cytokine levels, activated microglia and astrocyte levels, and nitrite levels as a measure for nitric oxide production and protein expression of iNOS. Exposure of the brain to 6 Gy induced a pronounced chronic inflammation response in the brain. The activated microglia load in the cortex and dentate gyrus region of hippocampus (P",

keywords = "Animals, Anti-Inflammatory Agents, Astrocytes, Body Weight, Brain, Cytokines, Diabetes Mellitus, Type 2, Eating, Glucagon-Like Peptide 1, Inflammation, Male, Mice, Mice, Inbred C57BL, Microglia, Nitric Oxide Synthase Type II, Nitrites, Radiation Injuries, Experimental",

author = "Vadivel Parthsarathy and Christian H{\"o}lscher",

year = "2013",

month = jan,

day = "30",

doi = "10.1016/j.ejphar.2012.12.012",

language = "English",

volume = "700",

pages = "42--50",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier",

number = "1-3",

}

RIS

TY - JOUR

T1 - The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain

AU - Parthsarathy, Vadivel

AU - Hölscher, Christian

PY - 2013/1/30

Y1 - 2013/1/30

N2 - Chronic inflammation in the brain is found in a range of neurodegenerative diseases such as Parkinson's or Alzheimer's disease. We have recently shown that analogues of the glucagon-like polypeptide 1 (GLP-1) such as liraglutide have potent neuroprotective properties in a mouse model of Alzheimer's disease. We also found a reduction of activated microglia in the brain. This finding suggests that GLP-1 analogues such as liraglutide have anti-inflammatory properties. To further characterise this property, we tested the effects of liraglutide on the chronic inflammation response induced by exposure of the brain to 6 Gy (X-ray). Animals were injected i.p. with 25 nmol/kg once daily for 30 days. Brains were analysed for cytokine levels, activated microglia and astrocyte levels, and nitrite levels as a measure for nitric oxide production and protein expression of iNOS. Exposure of the brain to 6 Gy induced a pronounced chronic inflammation response in the brain. The activated microglia load in the cortex and dentate gyrus region of hippocampus (P

AB - Chronic inflammation in the brain is found in a range of neurodegenerative diseases such as Parkinson's or Alzheimer's disease. We have recently shown that analogues of the glucagon-like polypeptide 1 (GLP-1) such as liraglutide have potent neuroprotective properties in a mouse model of Alzheimer's disease. We also found a reduction of activated microglia in the brain. This finding suggests that GLP-1 analogues such as liraglutide have anti-inflammatory properties. To further characterise this property, we tested the effects of liraglutide on the chronic inflammation response induced by exposure of the brain to 6 Gy (X-ray). Animals were injected i.p. with 25 nmol/kg once daily for 30 days. Brains were analysed for cytokine levels, activated microglia and astrocyte levels, and nitrite levels as a measure for nitric oxide production and protein expression of iNOS. Exposure of the brain to 6 Gy induced a pronounced chronic inflammation response in the brain. The activated microglia load in the cortex and dentate gyrus region of hippocampus (P

KW - Animals

KW - Anti-Inflammatory Agents

KW - Astrocytes

KW - Body Weight

KW - Brain

KW - Cytokines

KW - Diabetes Mellitus, Type 2

KW - Eating

KW - Glucagon-Like Peptide 1

KW - Inflammation

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Microglia

KW - Nitric Oxide Synthase Type II

KW - Nitrites

KW - Radiation Injuries, Experimental

U2 - 10.1016/j.ejphar.2012.12.012

DO - 10.1016/j.ejphar.2012.12.012

M3 - Journal article

C2 - 23276669

VL - 700

SP - 42

EP - 50

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 1-3

ER -

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