Home > Research > Publications & Outputs > The type 2 diabetes drug liraglutide reduces ch...
View graph of relations

The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain

Research output: Contribution to Journal/MagazineJournal articlepeer-review

<mark>Journal publication date</mark>30/01/2013
<mark>Journal</mark>European Journal of Pharmacology
Issue number1-3
Number of pages9
Pages (from-to)42-50
Publication StatusPublished
<mark>Original language</mark>English


Chronic inflammation in the brain is found in a range of neurodegenerative diseases such as Parkinson's or Alzheimer's disease. We have recently shown that analogues of the glucagon-like polypeptide 1 (GLP-1) such as liraglutide have potent neuroprotective properties in a mouse model of Alzheimer's disease. We also found a reduction of activated microglia in the brain. This finding suggests that GLP-1 analogues such as liraglutide have anti-inflammatory properties. To further characterise this property, we tested the effects of liraglutide on the chronic inflammation response induced by exposure of the brain to 6 Gy (X-ray). Animals were injected i.p. with 25 nmol/kg once daily for 30 days. Brains were analysed for cytokine levels, activated microglia and astrocyte levels, and nitrite levels as a measure for nitric oxide production and protein expression of iNOS. Exposure of the brain to 6 Gy induced a pronounced chronic inflammation response in the brain. The activated microglia load in the cortex and dentate gyrus region of hippocampus (P

Bibliographic note

Copyright © 2012 Elsevier B.V. All rights reserved.