Rights statement: The final publication is available at Springer via http://dx.doi.org/10.1007/s10549-015-3448-6 c The Author(s) 2015. This article is published with open access at Springerlink.com
Accepted author manuscript, 214 KB, PDF document
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Rights statement: c The Author(s) 2015. This article is published with open access at Springerlink.com
Final published version, 736 KB, PDF document
Available under license: CC BY: Creative Commons Attribution 4.0 International License
Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
| <mark>Journal publication date</mark> | 07/2015 |
|---|---|
| <mark>Journal</mark> | Breast Cancer Research and Treatment |
| Issue number | 1 |
| Volume | 152 |
| Number of pages | 8 |
| Pages (from-to) | 87-94 |
| Publication Status | Published |
| Early online date | 3/06/15 |
| <mark>Original language</mark> | English |
Women from breast cancer families without a demonstrable BRCA1/2 mutation were subjected to annual mammography from age 30 years onwards. One-hundred and ninety-eight patients were diagnosed prospectively with invasive breast cancer and followed for a total of 1513 years. Overall 10-year survival was 88 %. Together with our previous report that women in such kindreds had about twice the population risk of breast cancer, the combined conclusion was that the overall chances of developing breast cancer causing death within 10 years before 50 years of age was 1 % or less when subjected to annual mammography and current treatment. These are empirical prospective observations which may be used for genetic counselling. The majority (160/194 = 84 %) of patients had ER+ and/or low grade tumours with 92 % 10-year survival. One minor group of the patients had ER- tumours, another small group had high grade tumours with nodal spread, both groups were associated with worse prognosis, but the two groups were not mutually associated.