Rights statement: The final publication is available at Springer via http://dx.doi.org/10.1007/s10549-015-3448-6 c The Author(s) 2015. This article is published with open access at Springerlink.com
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Rights statement: c The Author(s) 2015. This article is published with open access at Springerlink.com
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Available under license: CC BY: Creative Commons Attribution 4.0 International License
Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Tumour characteristics and survival in familial breast cancer prospectively diagnosed by annual mammography
AU - Møller, Pål
AU - Tharmaratnam, Kukatharmini
AU - Howell, Anthony
AU - Stavrinos, Paula
AU - Sampson, Sarah
AU - Wallace, Andrew
AU - Maxwell, Anthony J.
AU - Hagen, Anne Irene
AU - Evans, D. Gareth
N1 - c The Author(s) 2015. This article is published with open access at Springerlink.com
PY - 2015/7
Y1 - 2015/7
N2 - Women from breast cancer families without a demonstrable BRCA1/2 mutation were subjected to annual mammography from age 30 years onwards. One-hundred and ninety-eight patients were diagnosed prospectively with invasive breast cancer and followed for a total of 1513 years. Overall 10-year survival was 88 %. Together with our previous report that women in such kindreds had about twice the population risk of breast cancer, the combined conclusion was that the overall chances of developing breast cancer causing death within 10 years before 50 years of age was 1 % or less when subjected to annual mammography and current treatment. These are empirical prospective observations which may be used for genetic counselling. The majority (160/194 = 84 %) of patients had ER+ and/or low grade tumours with 92 % 10-year survival. One minor group of the patients had ER- tumours, another small group had high grade tumours with nodal spread, both groups were associated with worse prognosis, but the two groups were not mutually associated.
AB - Women from breast cancer families without a demonstrable BRCA1/2 mutation were subjected to annual mammography from age 30 years onwards. One-hundred and ninety-eight patients were diagnosed prospectively with invasive breast cancer and followed for a total of 1513 years. Overall 10-year survival was 88 %. Together with our previous report that women in such kindreds had about twice the population risk of breast cancer, the combined conclusion was that the overall chances of developing breast cancer causing death within 10 years before 50 years of age was 1 % or less when subjected to annual mammography and current treatment. These are empirical prospective observations which may be used for genetic counselling. The majority (160/194 = 84 %) of patients had ER+ and/or low grade tumours with 92 % 10-year survival. One minor group of the patients had ER- tumours, another small group had high grade tumours with nodal spread, both groups were associated with worse prognosis, but the two groups were not mutually associated.
KW - Familial
KW - Breast cancer
KW - Survival
KW - Prospective study
KW - BRCA testing
U2 - 10.1007/s10549-015-3448-6
DO - 10.1007/s10549-015-3448-6
M3 - Journal article
C2 - 26037256
VL - 152
SP - 87
EP - 94
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
SN - 0167-6806
IS - 1
ER -