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Type I interferon is required for T helper (Th) 2 induction by dendritic cells

Research output: Contribution to journalJournal article

Published
  • Lauren M Webb
  • Rachel J Lundie
  • Jessica G Borger
  • Sheila L Brown
  • Lisa M Connor
  • Adam Nr Cartwright
  • Annette M Dougall
  • Ruud Hp Wilbers
  • Peter C Cook
  • Lucy H Jackson-Jones
  • Alexander T Phythian-Adams
  • Cecilia Johansson
  • Daniel M Davis
  • Benjamin G Dewals
  • Franca Ronchese
  • Andrew S MacDonald
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<mark>Journal publication date</mark>15/08/2017
<mark>Journal</mark>EMBO Journal
Issue number16
Volume36
Number of pages15
Pages (from-to)2404-2418
Publication StatusPublished
Early online date17/07/17
<mark>Original language</mark>English

Abstract

Type 2 inflammation is a defining feature of infection with parasitic worms (helminths), as well as being responsible for widespread suffering in allergies. However, the precise mechanisms involved in T helper (Th) 2 polarization by dendritic cells (DCs) are currently unclear. We have identified a previously unrecognized role for type I IFN (IFN-I) in enabling this process. An IFN-I signature was evident in DCs responding to the helminth Schistosoma mansoni or the allergen house dust mite (HDM). Further, IFN-I signaling was required for optimal DC phenotypic activation in response to helminth antigen (Ag), and efficient migration to, and localization with, T cells in the draining lymph node (dLN). Importantly, DCs generated from Ifnar1-/- mice were incapable of initiating Th2 responses in vivo These data demonstrate for the first time that the influence of IFN-I is not limited to antiviral or bacterial settings but also has a central role to play in DC initiation of Th2 responses.