Research outputs

• Quantifying the association between progression-free survival and overall survival in oncology trials using Kendall's tau.

  Research output: Contribution to journal › Journal article

• Generalization of Cramér-Rao and Bhattacharyya inequalities for the weighted covariance matrix

  Research output: Contribution to journal › Journal article

• A review of the deterministic and diffusion approximations for stochastic chemical reaction networks

  Research output: Contribution to journal › Journal article

• A Bayesian model to estimate the cutoff and the clinical utility of a biomarker assay

  Research output: Contribution to journal › Journal article

• A proposal for a new PhD level curriculum on quantitative methods for drug development

  Research output: Contribution to journal › Journal article

• An information-theoretic Phase I/II design for molecularly targeted agents that does not require an assumption of monotonicity

  Research output: Contribution to journal › Journal article

• A novel measure of drug benefit–risk assessment based on Scale Loss Score

  Research output: Contribution to journal › Journal article

• Adaptive designs for complex dose finding studies

  Research output: Thesis › Doctoral Thesis

• A benchmark for dose finding studies with continuous outcomes

  Research output: Contribution to journal › Journal article

• Randomized dose-escalation designs for drug combination cancer trials with immunotherapy

  Research output: Contribution to journal › Journal article

• Subgroup identification in clinical trials via the predicted individual treatment effect

  Research output: Contribution to journal › Journal article

• A robust Bayesian meta-analytic approach to incorporate animal data into phase I oncology trials

  Research output: Contribution to journal › Journal article

• Loss Functions in Restricted Parameter Spaces and Their Bayesian Applications

  Research output: Contribution to journal › Journal article

• Model selection based on combined penalties for biomarker identification

  Research output: Contribution to journal › Journal article

• Response to comments on Jaki et al., A proposal for a new PhD level curriculum on quantitative methods for drug development. Pharm Stat 17(5):593-606, Sep/Oct 2018., DOI https://doi.org/10.1002/pst.1873

  Research output: Contribution to journal › Letter

• Bayesian sequential integration within a preclinical pharmacokinetic and pharmacodynamic modeling framework: Lessons learned

  Research output: Contribution to journal › Journal article

• A flexible design for advanced Phase I/II clinical trials with continuous efficacy endpoints

  Research output: Contribution to journal › Journal article

• Improving safety of the continual reassessment method via a modified allocation rule

  Research output: Contribution to journal › Journal article

• A surface-free design for phase I dual-agent combination trials

  Research output: Contribution to journal › Journal article

• Using a Dose-Finding Benchmark to Quantify the Loss Incurred by Dichotomisation in Phase II Dose-Ranging Studies

  Research output: Contribution to journal › Journal article

• Using a dose-finding benchmark to quantify the loss incurred by dichotomization in Phase II dose-ranging studies

  Research output: Contribution to journal › Journal article