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Professor Thomas Jaki

Formerly at Lancaster University

PhD supervision

Using existing information in multi-arm multi-stage clinical trials

Multi-arm clinical trials compare several active treatments to a common control and have been proposed as an efficient means of making an informed decision about which of several treatments should be evaluated further in a confirmatory study. Additional efficiency is gained by incorporating interim analyses that allow the study to be stopped early - either because of overwhelming evidence of benefit or lack thereof.

This project will investigate design and analysis of multi-arm multi-stage clinical trials that incorporate existing information (e.g. from previous studies). A Bayesian framework will be use to integrate this information while frequentist properties of the design will be controlled.

Research Interests

  • Design and analysis of clinical trials
  • Early phase drug development
  • Personalized medicine
  • Biostatistics

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