Consider Design Research as a prophylactic rather than a therapeutic treatment. Rather than parachuting in doses of Design Research to help address specific problems, what if the Design Research became our default way of looking and superseded the dominance of scientism? This is a big idea; in fact, it would constitute a knowledge revolution. But given that Design is a synthetic discipline which connects points of view and amalgamates insights to produce holistic and inclusive perspectives, then it needn’t disregard or disrespect the virtues of positivism and scientism. Instead, it could galvanise them, strengthen them, and arrive at something new which is more than the sum of its parts. As we live through the pervasive and pernicious challenges of the 21st century—e.g., the far-reaching impact of AI, the post-truth era, and the climate crisis—then, arguably, this knowledge revolution is precisely the tonic our society needs to help remedy the emergent tumult at this delicately balanced point in history.