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Heparinoids as antidotes to spitting cobra envenoming

Press/Media: Research

Description

Various articles published based on our 2024 PNAS paper showing how heparinoids can inhibit cytotoxic 3-finger toxins in spitting cobra venoms.

Period18/07/2022 → 26/08/2024

Various articles published based on our 2024 PNAS paper showing how heparinoids can inhibit cytotoxic 3-finger toxins in spitting cobra venoms.

References

TitleCommon blood thinner a more effective antidote for cobra venom: Study
Degree of recognitionInternational
Media name/outletThe Strights Times
Primary Media typeWeb
Country/TerritorySingapore
Date26/08/24
DescriptionSINGAPORE – When a snake sinks its fangs into the flesh of its prey, toxins in its venom can destroy the victim’s tissue almost instantly.

Currently, the common treatment for snake bites is an anti-venom delivered to the bloodstream through an intravenous drip. But this does not prevent the venom from creating lesions in skin tissues, which can cause permanent limb damage or amputation.
PersonsSteve Hall
TitleCommon blood thinner could treat cobra venom – global study
Degree of recognitionInternational
Media name/outletJuta Medical Brief - Africa's Medical Media Digest
Primary Media typeWeb
Country/TerritorySouth Africa
Date24/07/24
DescriptionA commonly used blood thinner can be used as an antidote to cobra venom, an international study has suggested, research that experts have described as “really exciting” and which could help save lives.

PersonsSteve Hall
TitleAustralia, UK develop new antidote for snake bites using CRISPR technology
Degree of recognitionInternational
Media name/outletBio Spectrum Asia Edition
Primary Media typeWeb
Date23/07/24
DescriptionScientists at the University of Sydney, Australia and Liverpool School of Tropical Medicine, UK have made a remarkable discovery, i.e. a commonly used blood thinner, heparin, that can be repurposed as an inexpensive antidote for cobra venom.

PersonsSteve Hall
TitleCentury-Old Drug Could Stop Cobra Bites – Here’s How!
Media name/outletInfluence UK
Primary Media typeWeb
Country/TerritoryUnited Kingdom
Date23/07/24
DescriptionSnakebites, claiming up to 138,000 lives annually worldwide, may soon meet their match in an unexpected source – century-old blood thinners repurposed as potent antidotes against cobra venom. This groundbreaking discovery, detailed in a recent publication by researchers from the University of Sydney, the Liverpool School of Tropical Medicine, and Instituto Clodomiro Picado, could transform the landscape of snakebite treatment.

PersonsSteve Hall
TitleRemedy for dangerous cobra bites discovered
Media name/outletASB Zeitung
Primary Media typeWeb
Country/TerritoryGermany
Date22/07/24
DescriptionInexpensive, unprocessed, admitted

PersonsSteve Hall
TitleHow a century-old drug could revolutionise cobra bite treatment
Media name/outletThe Indian Express
Primary Media typeWeb
Country/TerritoryIndia
Date22/07/24
DescriptionSnakebites kill 138,000 yearly, but common blood thinners might be the new life-saving antidotes.
PersonsSteve Hall
TitleNew antidote for cobra bites discovered
Media name/outletDigital Journal
Primary Media typeWeb
Date22/07/24
DescriptionScientists working at the University of Sydney and Liverpool School of Tropical Medicine have discovered that the commonly used blood thinner, heparin, can be repurposed as an inexpensive antidote for cobra venom.

PersonsSteve Hall
TitleCommon Blood Thinners Could Combat Snakebites, Preventing Tissue Damage and Amputations, Study Finds
Degree of recognitionInternational
Media name/outletSmithosonian Magazine
Primary Media typeWeb
Country/TerritoryUnited States
Date22/07/24
DescriptionAn estimated 400,000 people per year are permanently disabled because of snake venom, which can cause lesions and necrosis at the bite site

PersonsSteve Hall
TitleBlood thinner may revolutionise cobra bite treatment in India
Media name/outletDNA India
Primary Media typeWeb
Country/TerritoryIndia
Date20/07/24
DescriptionIn such countries as India, the standard treatment for snakebites involves administering ‘antivenom’. To create it, scientists first gather venom from the specific snake species.

PersonsSteve Hall
TitleCobra venom just became less deadly, thanks to a common drug
Media name/outletEarth.com
Date19/07/24
DescriptionEvery year, thousands of people worldwide succumb to the lethal amounts of cobra venom injected into their bodies through bites.

These victims, often living in rural or impoverished regions with limited access to medical care, face not only the immediate threat of death but also the harrowing aftermath of envenomation.
PersonsSteve Hall
TitleScientists find that a common blood-thinning drug neutralises cobra venom
Degree of recognitionInternational
Media name/outletNation
Primary Media typeWeb
Country/TerritoryKenya
Date19/07/24
DescriptionScientists from the University of Sydney and Liverpool School of Tropical Medicine have discovered that a common blood-thinning drug can be repurposed as an antidote for cobra venom.

PersonsSteve Hall
TitleLatin America Could Attack Snakebites with New Antidote
Media name/outletLatin America Post
Date19/07/24
DescriptionLatin America, a region teeming with biodiversity, is grappling with a pressing health issue-snakebites, particularly in rural areas. The urgency of this crisis is underscored by the fact that these incidents are often underreported, earning the designation of a neglected tropical disease. A new anticoagulant-based antidote could be a game-changer, but better healthcare infrastructure and education are equally crucial.

PersonsSteve Hall
TitleHeparinoids class of drugs could revolutionise snake bite treatment https://www.bizzbuzz.news/industry/pharma/heparinoids-class-of-drugs-could-revolutionise-snake-bite-treatment-1329687
Media name/outletBizz Buzz
Date19/07/24
DescriptionHeparinoids are already inexpensive essential medicines used to prevent blood clots. The US Food and Drug Administration has approved them for self-administration in humans which may reduce the time required for the lengthy process of getting a drug to market
PersonsSteve Hall
TitleNew antidote for cobra bites discovered using CRISPR technology
Media name/outletThe University of Sydney
Primary Media typeWeb
Country/TerritoryAustralia
Date19/07/24
DescriptionCheap, available drug could help reduce impact of snakebites worldwide
PersonsSteve Hall
TitleCommon blood thinner possible cheap antidote to snakebite, study finds
Media name/outletPress Trust of India
Country/TerritoryIndia
Date19/07/24
DescriptionA common blood thinner drug could be a possible cheap antidote to treating snakebites, according to a research.

PersonsSteve Hall
TitleHow a common blood thinner can protect against spitting cobras
Degree of recognitionInternational
Media name/outletThe Telegraph
Primary Media typeWeb
Country/TerritoryUnited Kingdom
Date18/07/24
DescriptionScientists are excited about the ‘surprising’ discovery that heparin could limit the damage caused by the snake’s toxins

PersonsSteve Hall
TitleBlood Thinner Can Treat Flesh-Eating Cobra Venom, Scientists Discover
Media name/outletScience Alert
Primary Media typeWeb
Date18/07/24
DescriptionAbout 1.8 million people worldwide are bitten by snakes each year. Of those, up to 138,000 die and another 400,000 end up with permanent scarring and disability.Many cobras have tissue-damaging venoms that can't be treated with current antivenoms. We have discovered that cheap, readily available blood-thinning medications can be repurposed as antidotes for these venoms.

Using CRISPR gene-editing technology we learned more about how these venoms attack our cells, and found out that a common class of drugs called heparinoids can protect tissue from the venom. Our research is published today in Science Translational Medicine.

PersonsSteve Hall
TitleBreakthrough: Common blood thinner can be affordable antidote for cobra venom
Degree of recognitionInternational
Media name/outletThe Times of India
Primary Media typeWeb
Country/TerritoryIndia
Date18/07/24
PersonsSteve Hall
TitleHope commonly used blood thinner could revolutionise treatment for cobra bites
Degree of recognitionInternational
Media name/outletABC
Primary Media typeTelevision
Country/TerritoryAustralia
Date18/07/24
DescriptionVideo of paper's lead author and my collaborator, Tian Du, being interviewed by ABC for the project.
PersonsSteve Hall
TitleAustralian research discovers how common blood thinner can be used as cobra venom treatment
Media name/outletCosmos
Country/TerritoryAustralia
Date18/07/24
DescriptionThe anticoagulant heparin could be repurposed as a cheap and effective drug to treat cobra bites across Asia and Africa. According to the World Health Organization (WHO), up to 2 million people are envenomed by snakes each year in Asia, while in Africa there are an estimated 435,000 to 580,000 snake bites annually that need treatment.

PersonsSteve Hall
TitleScientists discover new antidote to cobra venom
Degree of recognitionInternational
Media name/outletThe Hindu
Primary Media typeWeb
Country/TerritoryIndia
Date18/07/24
DescriptionA commonly used blood thinner can be repurposed as an inexpensive antivenom treatment, a study published in Science Translational Medicine has said
PersonsSteve Hall
TitleCommon blood thinner possible cheap antidote to snakebite, study finds
Media name/outletThe South First
Primary Media typeWeb
Country/TerritoryIndia
Date18/07/24
DescriptionUsing the CRISPR technology to modify human genes, the team identified the different ways in which cobra venom could be blocked.

PersonsSteve Hall
TitleUK researchers help discover blood-thinning drug neutralises cobra venom bites
Degree of recognitionInternational
Media name/outletITV News
Primary Media typeWeb
Country/TerritoryUnited Kingdom
Date18/07/24
DescriptionA drug commonly prescribed to thin blood can be repurposed as a cheap antidote to cobra venom, researchers have found.

PersonsSteve Hall
TitleNew antidote for cobra bites discovered
Media name/outletAAAS EurekaAlert
Country/TerritoryUnited Kingdom
Date17/07/24
DescriptionScientists at the University of Sydney and Liverpool School of Tropical Medicine have made a remarkable discovery: a commonly used blood thinner, heparin, can be repurposed as an inexpensive antidote for cobra venom.
PersonsSteve Hall
TitleBreakthrough cobra venom antidote discovered
Degree of recognitionInternational
Media name/outletPopular Science
Primary Media typeWeb
Country/TerritoryUnited States
Date17/07/24
DescriptionA breakthrough from an international research team has produced a cheap new antidote to deadly cobra venom using a surprising source—a commonplace blood thinner.
PersonsSteve Hall
TitleSnakebite savior: CRISPR tech helps discover antidote for cobra venom
Media name/outletInteresting Engineering
Date17/07/24
DescriptionUsing CRISPR technology, researchers identified that heparin can block cobra venom targets, acting as a ‘decoy’ antidote to prevent necrosis and improve survival rates.
PersonsSteve Hall
TitleCommon blood-thinning drug neutralises cobra venom
Degree of recognitionInternational
Media name/outletBBC
Primary Media typeWeb
Country/TerritoryUnited Kingdom
Date17/07/24
DescriptionA drug commonly prescribed to thin blood can be repurposed as a cheap antidote to cobra venom, a team of scientists based in Australia, Canada, Costa Rica and the UK has discovered.

PersonsSteve Hall
TitleScientists discover new antidote for cobra bites that could save thousands of lives
Degree of recognitionInternational
Media name/outletThe Independent
Primary Media typeWeb
Country/TerritoryUnited Kingdom
Date17/07/24
DescriptionResearchers have discovered a new antidote for cobra bites.

PersonsSteve Hall
TitleBlood Thinner May Be New Cheap Antidote For Snake Bites, Study Suggests
Degree of recognitionInternational
Media name/outletForbes
Primary Media typeWeb
Country/TerritoryUnited States
Date17/07/24
DescriptionAvailable snake bite antivenoms are inconsistent at preventing tissue damage, and can cost thousands of dollars, so researchers found the common blood thinner heparin may be a cheap alternative to treat venomous snake bites and a more successful drug at preventing amputation.
PersonsSteve Hall
TitleBlood-thinning drug heparin may stop snakebite victims losing limbs
Degree of recognitionInternational
Media name/outletNew Scientist
Primary Media typeWeb
Country/TerritoryUnited Kingdom
Date17/07/24
DescriptionGiving mice the blood-thinning drug heparin after they were injected with venom from two cobra species reduced their risk of tissue death, which can lead to amputations
PersonsSteve Hall
TitleDeadly cobra bites to "drastically reduce" as scientists discover new antivenom
Media name/outletBBC Discover Wildlife
Primary Media typeWeb
Country/TerritoryUnited Kingdom
Date17/08/23
DescriptionAfter successful human trials, the snake venom antidote could be rolled out relatively quickly to become a "cheap, safe and effective drug for treating cobra bites" and saving lives around the globe, say scientists.
PersonsSteve Hall
TitleScientists now have an antidote for killer cobra venom. It's common blood thinner!
Media name/outletWION
Country/TerritoryAustralia
Date18/07/22
DescriptionThe antivenom treatment as of now is expensive, however, if the commonly used blood thinner is made into an antidote it can be a breakthrough in the world of medicine.
PersonsSteve Hall