Steve Hall - Research Portal | Lancaster University

Keywords

Pharmacology, Snakebite, Venom, Toxinology, Drugs

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Affiliations

Experimental medicine

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Dr Steve Hall

Lecturer in Pharmacology

Lancaster Medical School

Furness Building

LA1 4YG

Lancaster

E-mail: Show email

ORCID: 0000-0001-5314-4970

Research overview

Snakebite affects millions of people every year and is estimated to cause >100,000 deaths and 400,000 life-altering injuries annually. Conventional antivenoms are the current mainstay treatment but are associated with many issues including high cost, poor stability, being snake species-specific, the need to be delivered intravenously, and poor efficacy against local tissue necrosis caused by cytotoxic snake venoms. Dr Hall’s research is therefore focused on (i) the pharmacological determination of synergistic drug combinations with multi-species efficacy, and (ii) the development of local drug administration methods that could be exploited to better treat the devastating effects of snakebite-induced tissue necrosis.

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Publications & Outputs

Published
Editorial: Experimental and computational aspects of bioactive proteins from animal venoms: an insight into pharmacological properties and drug discovery
Khai Khun Yap, M., Modahl, C. & Hall, S., 16/02/2024, In: Frontiers in Pharmacology. 15, p. 1-3 3 p.
Research output: Contribution to Journal/Magazine › Editorial
Published
Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms
Hall, S. R., Rasmussen, S. A., Crittenden, E., Dawson, C. A., Bartlett, K. E., Westhorpe, A. P., Albulescu, L-O., Kool, J., Gutiérrez, J. M. & Casewell, N. R., 14/12/2023, In: Nature Communications. 14, 1, p. 1-15 15 p., 7812.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Machine-learning guided Venom Induced Dermonecrosis Analysis tooL : VIDAL
Laprade, W., Bartlett, K. E., Christensen, C. R., Kazandjian, T. D., Patel, R. N., Crittenden, E., Dawson, C. A., Mansourvar, M., Wolff, D. S., Fryer, T., Laustsen, A. H., Casewell, N. R., Gutiérrez, J. M., Hall, S. R. & Jenkins, T. P., 8/12/2023, In: Scientific Reports. 13, 1, 21662.
Research output: Contribution to Journal/Magazine › Journal article › peer-review