Additional file 1. Figure S1. RFAs inhibited NLRP3 inflammasome induced by uric acid, alum, SiO2 and CPPD. Figure S2. RFAs inhibited NLRP3 inflammasome in a dose dependent manner. Figure S3. RFAs inhibited the transcription of NLRP3 in a dose dependent manner. Figure S4. RFAs inhibited the assembly of NLRP3 inflammasome in a dose dependent manner. Figure S5. RFAs inhibited cholesterol induced NLRP3 inflammasome in mouse BMDMs in a dose dependent manner. Figure S6. RFAs inhibited cholesterol induced NLRP3 inflammasome in mouse Kuffer cells. Figure S7. RFAs inhibited cholesterol induced NLRP3 inflammasome in mouse primary hepatocytes. Figure S8. RFAs inhibited ALT and AST in mouse primary hepatocytes stimulated by LPS + cholesterol. Figure S9. RFAs improved MCD diet induced mice NAFLD by inhibiting NLRP3 inflammasome in the third week. Table S1. Main materials.