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Research

Professor Christian Holscher

Formerly at Lancaster University

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  1. 2015
  2. Published

    Restoration of cerebral and systemic microvascular architecture in APP/PS1 transgenic mice following treatment with Liraglutide™

    Kelly, P., McClean, P. L., Ackermann, M., Konerding, M. A., Holscher, C. & Mitchell, C. A., 02/2015, In: Microcirculation. 22, 2, p. 133-145 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. Published

    Neuroprotective effects of an oxyntomodulin analogue in the MPTP mouse model of Parkinson's disease

    Liu, W., Li, Y., Jalewa, J., Saunders-Wood, T., Li, L. & Hölscher, C., 2015, In: European Journal of Pharmacology. 765, p. 284-290 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. Published

    Quantitative measurement of [Na+] and [K+] in postmortem human brain tissue indicates disturbances in subjects with Alzheimer's Disease and dementia with Lewy bodies

    Graham, S. F., Nasarauddin, M. B., Carey, M., McGuinness, B., Holscher, C., Kehoe, P. G., Love, S., Passmore, A. P., Elliott, C. T., Meharg, A. & Green, B. D., 2015, In: Journal of Alzheimer's Disease. 44, 3, p. 851-857 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. 2014
  6. Published

    Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice

    Lennox, R., Porter, D. W., Flatt, P. R., Holscher, C., Irwin, N. & Gault, V. A., 11/2014, In: Neuropharmacology. 86, p. 22-30 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. Published

    Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease

    McClean, P. L. & Holscher, C., 11/2014, In: Neuropharmacology. 86, p. 241-258 18 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. Published

    Lixisenatide rescues spatial memory and synaptic plasticity from amyloid β protein-induced impairments in rats

    Cai, H-Y., Hölscher, C., Yue, X-H., Zhang, S-X., Wang, X-H., Qiao, F., Yang, W. & Qi, J-S., 26/09/2014, In: Neuroscience. 277, p. 6-13 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. Published

    Metabolic signatures of human Alzheimer's disease (AD): H-1 NMR analysis of the polar metabolome of post-mortem brain tissue

    Graham, S. F., Holscher, C. & Green, B. D., 08/2014, In: Metabolomics. 10, 4, p. 744-753 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    Peptide drugs that have been developed to treat type 2 diabetes show neuroprotective effects

    Holscher, C., 06/2014, In: Regulatory Peptides. 192-193, p. 55-56 2 p.

    Research output: Contribution to Journal/Magazine › Editorial › peer-review

  11. Published

    Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases

    Holscher, C., 1/04/2014, In: Journal of Endocrinology. 221, p. T31-T41 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  12. Published

    Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases

    Hölscher, C., 1/04/2014, In: Biochemical Society Transactions. 42, 2, p. 593-599 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  13. Published

    Neural circuit interactions between the dorsal raphe nucleus and the lateral hypothalamus: an experimental and computational study

    Jalewa, J., Joshi, A., McGinnity, T. M., Prasad, G., Wong-Lin, K. & Hölscher, C., 6/02/2014, In: PLoS ONE. 9, 2, 16 p., e88003.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  14. Published

    First clinical data of the neuroprotective effects of nasal insulin application in patients with Alzheimer's disease

    Hölscher, C., 02/2014, In: Alzheimer's and Dementia. 10, 1 Supplement, p. S33-37 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  15. Published

    Neuroprotective and anti-apoptotic effects of Liraglutide on SH-SY5Y cells exposed to Methylglyoxal stress

    Sharma, M., Jalewa, J. & Hölscher, C., 02/2014, In: Journal of Neurochemistry. 128, 3, p. 459-471 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  16. Published

    The incretin hormones glucagonlike peptide 1 and glucose-dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer's disease

    Hölscher, C., 02/2014, In: Alzheimer's and Dementia. 10, 1 Supplement, p. S47-54 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  17. Published

    Age-associated changes of brain copper, iron, and zinc in Alzheimer's disease and dementia with Lewy bodies

    Graham, S. F., Nasaruddin, M. B., Carey, M., Holscher, C., McGuinness, B., Kehoe, P. G., Love, S., Passmore, P., Elliott, C. T., Meharg, A. A. & Green, B. D., 2014, In: Journal of Alzheimer's Disease. 42, 4, p. 1407-1413 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  18. 2013
  19. Published

    TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-Amyloid oligomers in mice and monkeys

    Lourenco, M. V., Clarke, J. R., Frozza, R. L., Bomfim, T. R., Forny-Germano, L., Batista, A. F., Sathler, L. B., Brito-Moreira, J., Amaral, O. B., Silva, C. A., Freitas-Correa, L., Espírito-Santo, S., Campello-Costa, P., Houzel, J-C., Klein, W. L., Holscher, C., Carvalheira, J. B., Silva, A. M., Velloso, L. A., Munoz, D. P., & 2 othersFerreira, S. T. & De Felice, F. G., 3/12/2013, In: Cell Metabolism. 18, 6, p. 831-843 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  20. Published

    New animal models of Alzheimer's disease that display insulin desensitization in the brain

    Gao, C., Liu, Y., Li, L. & Hölscher, C., 12/2013, In: Reviews in the Neurosciences. 24, 6, p. 607-615 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  21. Published

    H-1 NMR metabolomics investigation of an Alzheimer's disease (AD) mouse model pinpoints important biochemical disturbances in brain and plasma

    Graham, S. F., Holscher, C., McClean, P., Elliot, C. T. & Green, B. D., 10/2013, In: Metabolomics. 9, 5, p. 974-983 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  22. Published

    Intranasal insulin as a treatment for Alzheimer’s Disease: a review of basic research and clinical evidence

    Freiherr, J., Hallschmid, M., Frey, W., Brünner, Y., Chapman, C., Holscher, C., Craft, S., De Felice, F. & Benedict, C., 07/2013, In: CNS Drugs. 27, 7, p. 505-514 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  23. Published

    Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice

    Porter, W. D., Flatt, P. R., Hölscher, C. & Gault, V. A., 05/2013, In: International Journal of Obesity. 37, 5, p. 678-684 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  24. Published

    Neuroprotective effects of D-Ala2GIP on Alzheimer’s disease biomarkers in an APP/PS1 mouse model

    Faivre, E. & Holscher, C., 19/04/2013, In: Alzheimer's Research and Therapy. 5, p. 20-29 10 p., 20.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  25. Published

    D-Ala2GIP facilitated synaptic plasticity and reduces plaque load in aged wild type mice and in an Alzheimer’s disease mouse model

    Faivre, E. & Holscher, C., 8/04/2013, In: Journal of Alzheimer's Disease. 35, 2, p. 267-283 17 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  26. Published

    Val⁸-GLP-1 remodels synaptic activity and intracellular calcium homeostasis impaired by amyloid β peptide in rats

    Wang, X-H., Yang, W., Hölscher, C., Wang, Z-J., Cai, H-Y., Li, Q-S. & Qi, J-S., 04/2013, In: Journal of Neuroscience Research. 91, 4, p. 568-577 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  27. Published

    Chronic treatment with the GLP1 analogue liraglutide increases cell proliferation and differentiation into neurons in an AD mouse model

    Parthsarathy, V. & Holscher, C., 11/03/2013, In: PLoS ONE. 8, 3, e58784.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  28. Published

    Beneficial actions of glucagon-like peptide 1 (GLP-1) on hippocampal synaptic plasticity, gene expression, oxidative stress and inflammation in mice with diet-induced obesity and insulin resistance

    Gault, V., Lennox, R., Porter, D., Holscher, C. & Flatt, P., 03/2013, In: Diabetic Medicine. 30, Supplement 1, p. 4 1 p., A9 (P99).

    Research output: Contribution to Journal/Magazine › Meeting abstract › peer-review

  29. Published

    The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease

    Long-Smith, C. M., Manning, S., McClean, P. L., Coakley, M. F., O'Halloran, D. J., Holscher, C. & O'Neill, C., 03/2013, In: NeuroMolecular Medicine. 15, 1, p. 102-114 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  30. Published

    Investigation of the human brain metabolome to identify potential markers for early diagnosis and therapeutic targets of Alzheimer's disease

    Graham, S. F., Chevallier, O. P., Roberts, D., Hölscher, C., Elliott, C. T. & Green, B. D., 5/02/2013, In: Analytical Chemistry. 85, 3, p. 1803-1811 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  31. Published

    Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats

    Han, W-N., Hölscher, C., Yuan, L., Yang, W., Wang, X-H., Wu, M-N. & Qi, J-S., 02/2013, In: Neurobiology of Aging. 34, 2, p. 576-588 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  32. Published

    The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain

    Parthsarathy, V. & Hölscher, C., 30/01/2013, In: European Journal of Pharmacology. 700, 1-3, p. 42-50 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  33. Published

    The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer's disease

    Duffy, A. M. & Hölscher, C., 3/01/2013, In: Neuroscience. 228, p. 294-300 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  34. Published

    Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer ‘s disease

    McClean, P. L. & Holscher, C., 2013, In: Neuropharmacology. 76, Part A, p. 57-67 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  35. 2012
  36. Published

    Potential roles of glucagon-like peptide-1 (GLP-1) in neuroprotection

    Holscher, C., 10/2012, In: CNS Drugs. 26, 10, p. 871-882 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  37. Published

    Effects of the glucagon-like polypeptide-1 analogue (Val8)GLP-1 on learning, progenitor cell proliferation and neurogenesis in the C57B/16 mouse brain

    McGovern, S. F. J., Hunter, K. & Hölscher, C., 14/09/2012, In: Brain Research. 1473, p. 204-213 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  38. Published

    The effect of ageing on neurogenesis and oxidative stress in the APP(swe)/PS1(deltaE9) mouse model of Alzheimer's disease

    Hamilton, A. & Holscher, C., 17/04/2012, In: Brain Research. 1449, p. 83-93 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  39. Published

    An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

    Bomfim, T. R., Forny-Germano, L., Sathler, L. B., Brito-Moreira, J., Houzel, J-C., Decker, H., Silverman, M. A., Kazi, H., Melo, H. M., McClean, P. L., Holscher, C., Arnold, S. E., Talbot, K., Klein, W. L., Munoz, D. P., Ferreira, S. T. & De Felice, F. G., 2/04/2012, In: Journal of Clinical Investigation. 122, 4, p. 1339-1353 15 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  40. Published

    GSK3: a key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer disease

    Gao, C., Hölscher, C., Liu, Y. & Li, L., 02/2012, In: Reviews in the Neurosciences. 23, 1, p. 1-11 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  41. Published

    Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice

    Gengler, S., McClean, P. L., McCurtin, R., Gault, V. A. & Holscher, C., 02/2012, In: Neurobiology of Aging. 33, 2, p. 265-276 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  42. Published

    (Val⁸) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains

    Li, L., Zhang, Z-F., Hölscher, C., Gao, C., Jiang, Y-H. & Liu, Y-Z., 15/01/2012, In: European Journal of Pharmacology. 674, 2-3, p. 280-286 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  43. Published

    Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice

    Faivre, E., Hamilton, A. & Hölscher, C., 15/01/2012, In: European Journal of Pharmacology. 674, 2-3, p. 294-306 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  44. Published

    Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis

    Hunter, K. & Holscher, C., 2012, In: BMC Neuroscience. 13, p. 33-38 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  45. 2011
  46. Published

    Hepcidin treatment modulates the expression of divalent metal transporter-1, ceruloplasmin, and ferroportin-1 in the rat cerebral cortex and hippocampus

    Li, L., Hölscher, C., Chen, B-B., Zhang, Z-F. & Liu, Y-Z., 12/2011, In: Biological Trace Element Research. 143, 3, p. 1581-1593 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  47. Published

    Diabetes as a risk factor for Alzheimer’s disease: insulin signalling impairment in the brain as an alternative model of Alzheimer’s disease

    Holscher, C., 08/2011, In: Biochemical Society Transactions. 39, 4, p. 891-897 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  48. Published

    The diabetes drug Liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease

    McClean, P. L., Parthsarathy, V., Faivre, E. & Holscher, C., 27/04/2011, In: Journal of Neuroscience. 31, 17, p. 6587-6594 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  49. Published

    Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis

    Faivre, E., Gault, V. A., Thorens, B. & Hölscher, C., 1/04/2011, In: Journal of Neurophysiology. 105, 4, p. 1574-1580 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  50. Published

    Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain

    Hamilton, A., Patterson, S., Porter, D., Gault, V. A. & Hölscher, C., 04/2011, In: Journal of Neuroscience Research. 89, 4, p. 481-489 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  51. Published

    Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice

    Porter, D. W., Irwin, N., Flatt, P. R., Hölscher, C. & Gault, V. A., 15/01/2011, In: European Journal of Pharmacology. 650, 2-3, p. 688-693 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  52. 2010
  53. Published

    Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance

    Porter, D. W., Kerr, B. D., Flatt, P. R., Hölscher, C. & Gault, V. A., 10/2010, In: Diabetes, Obesity and Metabolism. 12, 10, p. 891-899 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  54. Published

    Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet

    Gault, V. A., Porter, W. D., Flatt, P. R. & Holscher, C., 08/2010, In: International Journal of Obesity. 34, p. 1341-1344 4 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  55. Published

    Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer's disease

    Hölscher, C., 06/2010, In: Recent Patents on CNS Drug Discovery. 5, 2, p. 109-117 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  56. Published

    Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease

    McClean, P. L., Gault, V. A., Harriott, P. & Hölscher, C., 25/03/2010, In: European Journal of Pharmacology. 630, 1-3, p. 158-162 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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