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Professor David Middleton

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  1. 2014
  2. Published

    Synthesis of bufalin derivatives with inhibitory activity against prostate cancer cells

    Yuan, X-F., Tian, H-Y., Li, J., Jin, L., Jiang, S-T., Liu, K. W-K., Luo, C., Middleton, D. A., Esmann, M., Ye, W-C. & Jiang, R-W., 3/06/2014, In: Natural Product Research. 28, 11, p. 843-847 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. Published

    Expression and purification of the aortic amyloid polypeptide medin

    Davies, H. A., Wilkinson, M. C., Gibson, R. P. & Middleton, D. A., 06/2014, In: Protein Expression and Purification. 98, p. 32-37 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. Published

    Structures, chemotaxonomic significance, cytotoxic and Na+, K+-ATPase inhibitory activities of new cardenolides from Asclepias curassavica

    Zhang, R-R., Tian, H-Y., Tan, Y-F., Chung, T-Y., Sun, X-H., Xia, X., Ye, W-C., Middleton, D. A., Fedosova, N., Esmann, M., Tzen, J. T. C. & Jiang, R-W., 2014, In: Organic and Biomolecular Chemistry . 12, 44, p. 8919-8929 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. 2013
  6. Published

    Heparin promotes the rapid fibrillization of a peptide with low intrinsic amyloidogenicity

    Madine, J., Davies, H. A., Hughes, E. & Middleton, D. A., 17/12/2013, In: Biochemistry. 52, 50, p. 8984-8992 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. Published

    Insights into the Molecular Architecture of a Peptide Nanotube Using FTIR and Solid-State NMR Spectroscopic Measurements on an Aligned Sample

    Middleton, D. A., Madine, J., Castelletto, V. & Hamley, I. W., 27/09/2013, In: Angewandte Chemie International Edition. 52, 40, p. 10537-10540

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. Published

    Probing the contacts of a low-affinity substrate with a membrane-embedded transport protein using 1H-13C cross-polarisation magic-angle spinning solid-state NMR

    Patching, S. G., Henderson, P. J. F., Sharples, D. J. & Middleton, D. A., 03/2013, In: Molecular Membrane Biology. 30, 2, p. 129-37 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. 2012
  10. Published

    Site-specific identification of an aβ fibril-heparin interaction site by using solid-state NMR spectroscopy

    Madine, J., Pandya, M. J., Hicks, M. R., Rodger, A., Yates, E. A., Radford, S. E. & Middleton, D. A., 21/12/2012, In: Angewandte Chemie International Edition. 51, 52, p. 13140-3 4 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  11. Published

    Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks

    Madine, J., Davies, H. A., Shaw, C., Hamley, I. W. & Middleton, D. A., 21/03/2012, In: Chemical Communications. 48, 24, p. 2976-8 3 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  12. Published

    Amyloid-derived peptide forms self-assembled monolayers on gold nanoparticle with a curvature-dependent β-sheet structure

    Shaw, C. P., Middleton, D. A., Volk, M. & Lévy, R., 28/02/2012, In: ACS Nano. 6, 2, p. 1416-26 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  13. Published

    Solid-state NMR reveals differences in the packing arrangements of peptide aggregates derived from the aortic amyloid polypeptide medin

    Davies, H. A., Madine, J. & Middleton, D. A., 01/2012, In: June 2002. ISSN 1460-4582. 18, 1, p. 65-72 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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