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Professor David Middleton

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  1. Published

    Inhibitors of protein aggregation and toxicity

    Amijee, H., Madine, J., Middleton, D. A. & Doig, A. J., 08/2009, In: Biochemical Society Transactions. 37, Pt 4, p. 692-6 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  2. Published

    The dynamics and orientation of a lipophilic drug within model membranes determined by 13C solid-state NMR

    Boland, M. P. & Middleton, D. A., 7/01/2008, In: Physical Chemistry Chemical Physics. 10, 1, p. 178-85 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. Published

    Solid-state NMR reveals differences in the packing arrangements of peptide aggregates derived from the aortic amyloid polypeptide medin

    Davies, H. A., Madine, J. & Middleton, D. A., 01/2012, In: June 2002. ISSN 1460-4582. 18, 1, p. 65-72 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. Published

    Expression and purification of the aortic amyloid polypeptide medin

    Davies, H. A., Wilkinson, M. C., Gibson, R. P. & Middleton, D. A., 06/2014, In: Protein Expression and Purification. 98, p. 32-37 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. Published

    Comparisons with amyloid-β reveal an aspartate residue that stabilizes fibrils of the aortic amyloid peptide medin

    Davies, H., Madine, J. & Middleton, D., 20/03/2015, In: Journal of Biological Chemistry. 290, p. 7791-7803 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. Published

    Measurement of multiple torsional angles from one-dimensional solid-state NMR spectra: application to the conformational analysis of a ligand in its biological receptor site

    Edwards, R., Madine, J., Fielding, L. & Middleton, D. A., 14/11/2010, In: June 2002. ISSN 1460-4582. 12, 42, p. 13999-4008 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. Published

    A study of the membrane association and regulatory effect of the phospholemman cytoplasmic domain

    Hughes, E., Whittaker, C. A. P., Barsukov, I. L., Esmann, M. & Middleton, D. A., 04/2011, In: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1808, 4, p. 1021-31 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. Published

    Heparin-derived oligosaccharides interact with the phospholamban cytoplasmic domain and stimulate SERCA function

    Hughes, E., Edwards, R. & Middleton, D. A., 22/10/2010, In: Biochemical and Biophysical Research Communications. 401, 3, p. 370-5 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. Published

    Cytoplasmic residues of phospholamban interact with membrane surfaces in the presence of SERCA: a new role for phospholipids in the regulation of cardiac calcium cycling?

    Hughes, E., Clayton, J. C. & Middleton, D. A., 02/2009, In: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1788, 2, p. 559-66 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    Comparison of the structure and function of phospholamban and the Arginine-14 deficient mutant associated with dilated cardiomyopathy

    Hughes, E. & Middleton, D. A., 16/09/2014, In: PLoS ONE. 9, 9, 10 p., 106746.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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