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Professor David Middleton

Professor

  1. 2009
  2. Published

    Evaluation of beta-alanine- and GABA-substituted peptides as inhibitors of disease-linked protein aggregation

    Madine, J., Wang, X., Brown, D. R. & Middleton, D. A., 17/08/2009, In: June 2002. ISSN 1460-4582. 10, 12, p. 1982-7 6 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  3. Published

    Inhibitors of protein aggregation and toxicity

    Amijee, H., Madine, J., Middleton, D. A. & Doig, A. J., 08/2009, In: Biochemical Society Transactions. 37, Pt 4, p. 692-6 5 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  4. Published

    Structural analysis of uniformly (13)C-labelled solids from selective angle measurements at rotational resonance

    Patching, S. G., Edwards, R. & Middleton, D. A., 08/2009, In: June 2002. ISSN 1460-4582. 199, 2, p. 242-6 5 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  5. Published

    Solid-state NMR studies of adenosine 5'-triphosphate freeze-trapped in the nucleotide site of Na,K-ATPase

    Middleton, D. A., Hughes, E., Fedosova, N. U. & Esmann, M., 20/07/2009, In: June 2002. ISSN 1460-4582. 10, 11, p. 1789-92 4 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  6. Published

    Exploiting a (13)C-labelled heparin analogue for in situ solid-state NMR investigations of peptide-glycan interactions within amyloid fibrils

    Madine, J., Clayton, J. C., Yates, E. A. & Middleton, D. A., 7/06/2009, In: Organic and Biomolecular Chemistry . 7, 11, p. 2414-20 7 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  7. Published

    Cross-beta spine architecture of fibrils formed by the amyloidogenic segment NFGSVQFV of medin from solid-state NMR and X-ray fiber diffraction measurements

    Madine, J., Copland, A., Serpell, L. C. & Middleton, D. A., 14/04/2009, In: Biochemistry. 48, 14, p. 3089-99 11 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  8. Published

    Cytoplasmic residues of phospholamban interact with membrane surfaces in the presence of SERCA: a new role for phospholipids in the regulation of cardiac calcium cycling?

    Hughes, E., Clayton, J. C. & Middleton, D. A., 02/2009, In: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1788, 2, p. 559-66 8 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  9. 2008
  10. Published

    Structural insights into the polymorphism of amyloid-like fibrils formed by region 20-29 of amylin revealed by solid-state NMR and X-ray fiber diffraction

    Madine, J., Jack, E., Stockley, P. G., Radford, S. E., Serpell, L. C. & Middleton, D. A., 12/11/2008, In: Journal of the American Chemical Society. 130, 45, p. 14990-5001 12 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  11. Published

    Relative substrate affinities of wild-type and mutant forms of the Escherichia coli sugar transporter GalP determined by solid-state NMR

    Patching, S. G., Psakis, G., Baldwin, S. A., Baldwin, J., Henderson, P. J. F. & Middleton, D. A., 09/2008, In: Molecular Membrane Biology. 25, 6-7, p. 474-84 11 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  12. Published

    The effects of alpha-synuclein on phospholipid vesicle integrity: a study using 31P NMR and electron microscopy

    Madine, J., Hughes, E., Doig, A. J. & Middleton, D. A., 09/2008, In: Molecular Membrane Biology. 25, 6-7, p. 518-27 10 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

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