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Dr David Townsend

Formerly at Lancaster University

  1. 2022
  2. Published

    Asgard archaea shed light on the evolutionary origins of the eukaryotic ubiquitin-ESCRT machinery

    Hatano, T., Palani, S., Papatziamou, D., Salzer, R., Souza, D. P., Tamarit, D., Makwana, M., Potter, A., Haig, A., Xu, W., Townsend, D., Rochester, D., Bellini, D., Hussain, H. M. A., Ettema, T. J. G., Löwe, J., Baum, B., Robinson, N. P. & Balasubramanian, M., 13/06/2022, In: Nature Communications. 13, 1, 16 p., 3398.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  3. 2021
  4. Published

    19F Solid-State NMR and Vibrational Raman Characterization of Corticosteroid Drug-Lipid Membrane Interactions

    Mapley, B., Townsend, D., Griffin, J., Ashton, L. & Middleton, D., 15/11/2021, In: ChemPlusChem. 86, 11, p. 1517-1523 7 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  5. Published

    Characterisation of the Ubiquitin-ESCRT pathway in Asgard archaea sheds new light on origins of membrane trafficking in eukaryotes

    Hatano, T., Palani, S., Papatziamou, D., Souza, D., Salzer, R., Tamarit, D., Makwana, M., Potter, A., Haig, A., Xu, W., Townsend, D., Rochester, D., Bellini, D., Hussain, H., Ettema, T., Löwe, J., Baum, B., Robinson, N. & Balasubramanian, M., 17/08/2021, In: Biorxiv. 27 p.

    Research output: Contribution to Journal/MagazineJournal article

  6. Published

    Potential for Chemistry in Multidisciplinary, Interdisciplinary, and Transdisciplinary Teaching Activities in Higher Education

    Hardy, J., Sdepanian, S., Stowell, A., Aljohani, A., Allen, M., Anwar, A., Barton, D., Baum, J., Bird, D., Blaney, A., Brewster, L., Cheneler, D., Efremova, O., Entwistle, M., Esfahani, R., Firlak, M., Foito, A., Forciniti, L., Geissler, S., Guo, F. & 19 others, Hathout, R., Jiang, R., Kevin, P., Leese, D., Low, W. L., Mayes, S., Mozafari, M., Murphy, S., Nguyen, H., Ntola, C., Okafo, G., Partington, A., Prescott, T., Price, S., Soliman, S., Sutar, P., Townsend, D., Trotter, P. & Wright, K., 4/03/2021, In: Journal of Chemical Education. 98, 4, p. 1124–1145 22 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  7. 2020
  8. Published

    Raman Spectroscopy with 2D Perturbation Correlation Moving Windows for the Characterization of Heparin–Amyloid Interactions

    Townsend, D., Middleton, D. & Ashton, L., 31/10/2020, In: Analytical Chemistry. 92, 20, p. 13822–13828 7 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  9. E-pub ahead of print

    Aggregation Kinetics and Filament Structure of a Tau Fragment Are Influenced by the Sulfation Pattern of the Cofactor Heparin

    Townsend, D., Fullwood, N., Yates, E. & Middleton, D., 21/09/2020, (E-pub ahead of print) In: Biochemistry.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  10. E-pub ahead of print

    Circular dichroism spectroscopy identifies the β-adrenoceptor agonist salbutamol as a direct inhibitor of tau filament formation in vitro.

    Middleton, D., Townsend, D., Hughes, E., Fullwood, N., Siligardi, G., Hussain, R. & Mala, B., 10/06/2020, (E-pub ahead of print) In: ACS Chemical Neuroscience.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  11. Published

    Electroactive Silk Fibroin Films for Electrochemically Enhanced Delivery of Drugs

    Mousavi, S., Harper, G., Municoy, S., Ashton, M., Townsend, D., Alsharif, G., Oikonomou, V., Au-Yong, S., Murdock, B., Akien, G., Halcovitch, N., Baldock, S., Fazilati, M., Kolosov, O., Robinson, B., Desimone, M. & Hardy, J., 1/06/2020, In: Macromolecular Materials and Engineering. 305, 6, 7 p., 2000130.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  12. 2018
  13. Published

    Orientation of a Diagnostic Ligand Bound to Macroscopically Aligned Amyloid-β Fibrils Determined by Solid-State NMR

    Townsend, D. J., Hughes, E., Stewart, K., Griffin, J. M., Radford, S. & Middleton, D. A., 15/11/2018, In: The Journal of Physical Chemistry Letters. 9, 22, p. 6611–6615 5 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  14. Published

    Epigallocatechin-3-gallate remodels apolipoprotein A-I amyloid fibrils into soluble oligomers in the presence of heparin

    Townsend, D., Hughes, E., Akien, G., Stewart, K. L., Radford, S. E., Rochester, D. & Middleton, D. A., 17/08/2018, In: Journal of Biological Chemistry. 293, 33, p. 12877-12893 17 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  15. 2017
  16. Published

    Heparin and methionine oxidation promote the formation of apolipoprotein A-I amyloid comprising α-helical and β-sheet structures.

    Townsend, D. J., Hughes, E., Hussain, R., Siligardi, G., Baldock, S. J., Madine, J. & Middleton, D. A., 21/03/2017, In: Biochemistry. 56, 11, p. 1632-1644 13 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  17. 2016
  18. Published

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