Edward Parkin - Publications & Outputs - Research Portal

Dr Edward Parkin

Senior Lecturer in Biomedicine

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Published
A role for calcium and annexins in the formation of caveolae
Parkin, E., Turner, A. J. & Hooper, N. M., 08/1996, In: Biochemical Society Transactions. 24, 3, p. 444S 1 p.
Research output: Contribution to Journal/Magazine › Journal article
Published
Distribution of presenilins and amyloid precursor protein in detergent-insoluble membrane microdomains
Parkin, E., Turner, A. & Hooper, N., 1999, Alzheimer's disease: methods and protocols. Hooper, N. M. (ed.). Humana Press, p. 345-360 16 p.
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter
Published
Alpha-Secretase and Alzheimer's disease
Parkin, E., 2008, Recent advances in the biology of secretases, key proteases in Alzheimer's disease. Araki, W. (ed.). Research Signpost, p. 183-211 29 p.
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter
Published
Cell proliferation and CTP: cholinephosphate cytidyhltraitsferase activity in higher plahts
Parkin, E. T. & Rolph, C. E., 1/08/1998, In: Biochemical Society Transactions. 26, 3, p. S219
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Detergent solubility and processing of the familial Alzheimer's disease-related presenilin proteins
Parkin, E. T., Turner, A. J. & Hooper, N. M., 1/08/1998, In: Biochemical Society Transactions. 26, 3, p. S241
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Effects of sterol biosynthesis inhibitors on phosphatidylcholine biosynthesis in Apium graveolens
Parkin, E. T., Goad, L. J. & Rolph, C. E., 1/11/1994, In: Biochemical Society Transactions. 22, 4, p. 432S
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Studies on CTP: Cholinephosphate cytidylyltransferase in Apium graveolens
Parkin, E. T., Goad, J. L. & Rolph, C. E., 1/05/1993, In: Biochemical Society Transactions. 21, 2, p. 77S
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
The orphan drug dichloroacetate reduces amyloid beta-peptide production whilst promoting non-amyloidogenic proteolysis of the amyloid precursor protein
Parkin, E. T., Hammond, J. E., Owens, L. & Hodges, M. D., 13/01/2022, In: PLoS ONE. 17, 1, 21 p., e0255715.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Osteonectin as a screening marker for pancreatic cancer: A prospective study
Papapanagiotou, A., Sgourakis, G., Karkoulias, K., Raptis, D., Parkin, E. T., Brotzakis, P., Panchal, S. & Papavassiliou, A., 1/07/2018, In: Journal of International Medical Research. 46, 7, p. 2769-2779 11 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Gene therapy-mediated enhancement of protective protein expression for the treatment of Alzheimer's disease
Owens, L., Benedetto, A., Dawson, N., Gaffney, C. & Parkin, E., 15/02/2021, In: Brain Research. 1753, 12 p., 147264.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
BACE1 Overexpression Reduces SH-SY5Y Cell Viability Through a Mechanism Distinct from Amyloid-β Peptide Accumulation: Beta Prime-Mediated Competitive Depletion of sAβPPα
Owens, L., Bracewell, J., Benedetto, A., Dawson, N., Gaffney, C. & Parkin, E., 5/04/2022, In: Journal of Alzheimer's Disease. 86, 3, p. 1201-1220 20 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Notch Signalling as a Therapeutic Target in Cancer
Martinas, I. & Parkin, E. T., 10/2016, In: International Journal of Cancer Therapy and Oncology. 4, 4
Research output: Contribution to Journal/Magazine › Literature review › peer-review
Published
Angiotensin-converting enzyme as a GPlase : a critical reevaluation.
Leisle, L., Parkin, E. T., Turner, A. J. & Hooper, N. M., 11/2005, In: Nature Medicine. 11, 11, p. 1139-1140 2 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Tumor Necrosis Factor- Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2).
Lambert, D. W., Yarski, M., Warner, F. J., Thornhill, P., Parkin, E. T., Smith, A. I., Hooper, N. M. & Turner, A. J., 26/08/2005, In: Journal of Biological Chemistry. 280, 34, p. 30113-30119 7 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Inactivation of a tachykinin-related peptide: identification of four neuropeptide-degrading enzymes in neuronal membranes of insects from four different orders.
Isaac, R. E., Parkin, E. T., Keen, J. N., Nässel, D. R., Siviter, R. J. & Shirras, A. D., 04/2002, In: Peptides. 23, 4, p. 725-733 9 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
The role of proteolysis in Alzheimer's disease.
Hooper, N. M., Trew, A. J., Parkin, E. T. & Turner, A. J., 2000, Cellular peptidases in immune functions and diseases. Langner, J. & Ansorge, S. (eds.). Plenum, p. 379-390 12 p.
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter
Published
The amyloid precursor protein represses expression of acetylcholinesterase in neuronal cell lines
Hicks, D. A., Makova, N. Z., Gough, M., Parkin, E. T., Nalivaeva, N. N. & Turner, A. J., 6/09/2013, In: Journal of Biological Chemistry. 288, 36, p. 26039-26051 13 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein
Harris, B., Pereira, I. & Parkin, E., 16/10/2009, In: Brain Research. 1296, n/a, p. 203-215 13 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Zinc metalloproteinases and amyloid Beta-Peptide metabolism: the positive side of proteolysis in Alzheimer's disease
Gough, M., Parr-Sturgess, C. & Parkin, E., 2011, In: Biochemistry Research International. 2011, 13 p., 721463.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
The E1 copper binding domain of full-length amyloid precursor protein mitigates copper-induced growth inhibition in brain metastatic prostate cancer DU145 cells
Gough, M., Blanthorn-Hazell, S., Delury, C. & Parkin, E., 31/10/2014, In: Biochemical and Biophysical Research Communications. 453, 4, p. 741-747 7 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
The histidine composition of the amyloid-β domain, but not the E1 copper binding domain, modulates β-secretase processing of amyloid-β protein precursor in Alzheimer's disease
Gough, M., Blanthorn-Hazell, S. & Parkin, E. T., 2015, In: Journal of Alzheimer's Disease. 43, 4, p. 1163-1168 6 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
The E1 copper binding domain of full-length amyloid precursor protein promotes epithelial to mesenchymal transition in DU145 cells in isoform-specific manner
Gough, M., Delury, C. & Parkin, E., 2015, In: International Journal of Biochemistry Research and Review. 6, 1, p. 264-273 10 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Differential regulation of E-cadherin expression by the soluble ectodomain and intracellular domain of jagged1
Delury, C., Tinker, C., Rivers, S., Hodges, M., Broughton, S. & Parkin, E., 2/08/2013, In: International Journal of Biochemistry Research and Review. 3, 4, p. 278-290 13 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Stroma-induced Jagged1 expression drives PC3 prostate cancer cell migration: disparate effects of RIP-generated proteolytic fragments on cell behaviour and Notch signaling
Delury, C. P., Hart, C., Brown, M., Clarke, N. & Parkin, E. T., 25/03/2016, In: Biochemical and Biophysical Research Communications. 472, 1, p. 255-261 7 p.
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Published
Pyruvate dehydrogenase kinase inhibition: reversing the Warburg effect in cancer therapy
Bell, H. & Parkin, E. T., 23/06/2016, In: International Journal of Cancer Therapy and Oncology. 4, 2, p. 4215-4227 12 p.
Research output: Contribution to Journal/Magazine › Literature review › peer-review

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Research

Dr Edward Parkin

A role for calcium and annexins in the formation of caveolae

Distribution of presenilins and amyloid precursor protein in detergent-insoluble membrane microdomains

Alpha-Secretase and Alzheimer's disease

Cell proliferation and CTP: cholinephosphate cytidyhltraitsferase activity in higher plahts

Detergent solubility and processing of the familial Alzheimer's disease-related presenilin proteins

Effects of sterol biosynthesis inhibitors on phosphatidylcholine biosynthesis in Apium graveolens

Studies on CTP: Cholinephosphate cytidylyltransferase in Apium graveolens

The orphan drug dichloroacetate reduces amyloid beta-peptide production whilst promoting non-amyloidogenic proteolysis of the amyloid precursor protein

Osteonectin as a screening marker for pancreatic cancer: A prospective study

Gene therapy-mediated enhancement of protective protein expression for the treatment of Alzheimer's disease

BACE1 Overexpression Reduces SH-SY5Y Cell Viability Through a Mechanism Distinct from Amyloid-β Peptide Accumulation: Beta Prime-Mediated Competitive Depletion of sAβPPα

Notch Signalling as a Therapeutic Target in Cancer

Angiotensin-converting enzyme as a GPlase : a critical reevaluation.

Tumor Necrosis Factor- Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2).

Inactivation of a tachykinin-related peptide: identification of four neuropeptide-degrading enzymes in neuronal membranes of insects from four different orders.

The role of proteolysis in Alzheimer's disease.

The amyloid precursor protein represses expression of acetylcholinesterase in neuronal cell lines

Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein

Zinc metalloproteinases and amyloid Beta-Peptide metabolism: the positive side of proteolysis in Alzheimer's disease

The E1 copper binding domain of full-length amyloid precursor protein mitigates copper-induced growth inhibition in brain metastatic prostate cancer DU145 cells

The histidine composition of the amyloid-β domain, but not the E1 copper binding domain, modulates β-secretase processing of amyloid-β protein precursor in Alzheimer's disease

The E1 copper binding domain of full-length amyloid precursor protein promotes epithelial to mesenchymal transition in DU145 cells in isoform-specific manner

Differential regulation of E-cadherin expression by the soluble ectodomain and intracellular domain of jagged1

Stroma-induced Jagged1 expression drives PC3 prostate cancer cell migration: disparate effects of RIP-generated proteolytic fragments on cell behaviour and Notch signaling

Pyruvate dehydrogenase kinase inhibition: reversing the Warburg effect in cancer therapy

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