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Research

Dr Edward Parkin

Senior Lecturer in Biomedicine

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  1. 2016
  2. Published

    Pyruvate dehydrogenase kinase inhibition: reversing the Warburg effect in cancer therapy

    Bell, H. & Parkin, E. T., 23/06/2016, In: International Journal of Cancer Therapy and Oncology. 4, 2, p. 4215-4227 12 p.

    Research output: Contribution to Journal/Magazine › Literature review › peer-review

  3. Published

    Stroma-induced Jagged1 expression drives PC3 prostate cancer cell migration: disparate effects of RIP-generated proteolytic fragments on cell behaviour and Notch signaling

    Delury, C. P., Hart, C., Brown, M., Clarke, N. & Parkin, E. T., 25/03/2016, In: Biochemical and Biophysical Research Communications. 472, 1, p. 255-261 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. 2015
  5. Published

    The E1 copper binding domain of full-length amyloid precursor protein promotes epithelial to mesenchymal transition in DU145 cells in isoform-specific manner

    Gough, M., Delury, C. & Parkin, E., 2015, In: International Journal of Biochemistry Research and Review. 6, 1, p. 264-273 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. Published

    The histidine composition of the amyloid-β domain, but not the E1 copper binding domain, modulates β-secretase processing of amyloid-β protein precursor in Alzheimer's disease

    Gough, M., Blanthorn-Hazell, S. & Parkin, E. T., 2015, In: Journal of Alzheimer's Disease. 43, 4, p. 1163-1168 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. 2014
  8. Published

    The E1 copper binding domain of full-length amyloid precursor protein mitigates copper-induced growth inhibition in brain metastatic prostate cancer DU145 cells

    Gough, M., Blanthorn-Hazell, S., Delury, C. & Parkin, E., 31/10/2014, In: Biochemical and Biophysical Research Communications. 453, 4, p. 741-747 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. 2013
  10. Published

    The amyloid precursor protein represses expression of acetylcholinesterase in neuronal cell lines

    Hicks, D. A., Makova, N. Z., Gough, M., Parkin, E. T., Nalivaeva, N. N. & Turner, A. J., 6/09/2013, In: Journal of Biological Chemistry. 288, 36, p. 26039-26051 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  11. Published

    Differential regulation of E-cadherin expression by the soluble ectodomain and intracellular domain of jagged1

    Delury, C., Tinker, C., Rivers, S., Hodges, M., Broughton, S. & Parkin, E., 2/08/2013, In: International Journal of Biochemistry Research and Review. 3, 4, p. 278-290 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  12. 2012
  13. Published

    Copper modulates zinc metalloproteinase-dependent ectodomain shedding of key signalling and adhesion proteins and promotes the invasion of prostate cancer epithelial cells

    Parr-Sturgess, C. A., Tinker, C. L., Hart, C. A., Brown, M. D., Clarke, N. W. & Parkin, E. T., 10/2012, In: Molecular Cancer Research. 10, 10, p. 1282-1293 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  14. 2011
  15. Published

    Zinc metalloproteinases and amyloid Beta-Peptide metabolism: the positive side of proteolysis in Alzheimer's disease

    Gough, M., Parr-Sturgess, C. & Parkin, E., 2011, In: Biochemistry Research International. 2011, 13 p., 721463.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  16. 2010
  17. Published

    Development of a proteolytically stable retro-inverso peptide inhibitor of β-amyloid oligomerization as a potential novel treatment for Alzheimer's disease

    Taylor, M., Moore, S., Mayes, J., Parkin, E., Beeg, M., Canovi, M., Gobbi, M., Mann, D. M. A. & Allsop, D., 2010, In: Biochemistry. 49, 15, p. 3261-3272 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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