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Development of a proteolytically stable retro-inverso peptide inhibitor of β-amyloid oligomerization as a potential novel treatment for Alzheimer's disease

Research output: Contribution to Journal/MagazineJournal articlepeer-review

<mark>Journal publication date</mark>2010
Issue number15
Number of pages12
Pages (from-to)3261-3272
Publication StatusPublished
<mark>Original language</mark>English


The formation of beta-amyloid (Abeta) deposits in the brain is likely to be a seminal step in the development of Alzheimer's disease. Recent studies support the hypothesis that Abeta soluble oligomers are toxic to cells and have potent effects on memory and learning. Inhibiting the early stages of Abeta aggregation could, therefore, provide a novel approach to treating the underlying cause of AD. We have designed a retro-inverso peptide (RI-OR2, H(2)N-r