Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis

UK NIHR BioResource Rare Diseases Consortium, UK PAH Cohort Study Consortium, US PAH Biobank Consortium, Rhodes, C. J., Batai, K., Bleda, M., Haimel, M., Southgate, L., Germain, M., Pauciulo, M. W., Hadinnapola, C., Aman, J., Girerd, B., Arora, A., Knight, J., Hanscombe, K. B., Karnes, J. H., Kaakinen, M., Gall, H., Ulrich, A., & 33 othersHarbaum, L., Cebola, I., Ferrer, J., Lutz, K., Swietlik, E. M., Ahmad, F., Amouyel, P., Archer, S. L., Argula, R., Austin, E. D., Badesch, D., Bakshi, S., Barnett, C., Benza, R., Bhatt, N., Bogaard, H. J., Burger, C. D., Chakinala, M., Church, C., Coghlan, J. G., Condliffe, R., Corris, P. A., Danesino, C., Debette, S., Elliott, C. G., Elwing, J., Eyries, M., Fortin, T., Franke, A., Frantz, R. P., Frost, A., Garcia, J. G. N. & Ghio, S., 1/03/2019, In: Lancet Respiratory Medicine. 7, 3, p. 227-238 12 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Genetic epistasis regulates amyloid deposition in resilient aging

Felsky, D., Xu, J., Chibnik, L., Schneider, J., Knight, J., Kennedy, J. L., Bennett, D. A., De Jager, P. L. & Voineskos, A. N., 10/2017, In: Alzheimer's and Dementia. 13, 10, p. 1107-1116 10 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

Schizophrenia Working Group of the Psychiatric Genomics Consortium, 03/2016, In: Nature Reviews Neuroscience. 19, 3, p. 420-431 12 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Genetic Markers of Human Evolution Are Enriched in Schizophrenia

Schizophrenia Working Group of the Psychiatric Genomics Consortium, The International Headache Genetics Consortium, 15/08/2016, In: Biological Psychiatry. 80, 4, p. 284-92 9 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Genetic Prediction of Smoking Cessation Medication Side Effects: A Genome‐Wide Investigation of Abnormal Dreams on Varenicline

Chenoweth, M. J., Kim, Y. J., Nollen, N. L., Hawk, L. W., Mahoney, M. C., Lerman, C., Knight, J. & Tyndale, R. F., 1/06/2024, In: Clinical pharmacology and therapeutics. 115, 6, p. 1277-1281

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

Warren, H. R., Evangelou, E., Cabrera, C. P., Gao, H., Ren, M., Mifsud, B., Ntalla, I., Surendran, P., Liu, C., Cook, J. P., Kraja, A. T., Drenos, F., Loh, M., Verweij, N., Marten, J., Karaman, I., Lepe, M. P. S., O'Reilly, P. F., Knight, J., Snieder, H., & 31 othersKato, N., He, J., Tai, E. S., Said, M. A., Porteous, D., Alver, M., Poulter, N., Farrall, M., Gansevoort, R. T., Padmanabhan, S., Mägi, R., Stanton, A., Connell, J., Bakker, S. J. L., Metspalu, A., Shields, D. C., Thom, S., Brown, M., Sever, P., Esko, T., Hayward, C., van der Harst, P., Saleheen, D., Chowdhury, R., Chambers, J. C., Chasman, D. I., Chakravarti, A., Newton-Cheh, C., Lindgren, C. M., Levy, D. & International Consortium of Blood Pressure (ICBP) 1000G Analyses, 20/02/2017, In: Nature Genetics. 49, p. 403-415 13 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Genome-wide association studies suggest limited immune gene enrichment in schizophrenia compared to 5 autoimmune diseases

Pouget, J. G., Gonçalves, V. F., Spain, S. L., Finucane, H. K., Raychaudhuri, S., Kennedy, J. L., Knight, J. & Schizophrenia Working Group of the Psychiatric Genomics Consortium, 09/2016, In: Schizophrenia Bulletin. 42, 5, p. 1176-1184 9 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris

Navarini, A. A., Simpson, M. A., Weale, M., Knight, J., Carlavan, I., Reiniche, P., Burden, D. A., Layton, A., Bataille, V., Allen, M., Pleass, R., Pink, A., Creamer, D., English, J., Munn, S., Walton, S., Willis, C., Déret, S., Voegel, J. J., Spector, T., & 4 othersSmith, C. H., Trembath, R. C., Barker, J. N. W. N. & Acne Genetic Study Group, 13/06/2014, In: Nature Communications. 5, 6 p., 4020.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences

Chenoweth, M. J., Ware, J. J., Zhu, A. Z. X., Cole, C. B., Cox, L. S., Nollen, N., Ahluwalia, J. S., Benowitz, N. L., Schnoll, R. A., Hawk, L. W., Cinciripini, P. M., George, T. P., Lerman, C., Knight, J., Tyndale, R. F. & PGRN-PNAT Research Group, 03/2018, In: Addiction. 113, 3, p. 509-523 15 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and CSMD1

Xu, W., Cohen-Woods, S., Chen, Q., Noor, A., Knight, J., Hosang, G., Parikh, S. V., De Luca, V., Tozzi, F., Muglia, P., Forte, J., McQuillin, A., Hu, P., Gurling, H. M. D., Kennedy, J. L., McGuffin, P., Farmer, A., Strauss, J. & Vincent, J. B., 4/01/2014, In: Journal of Medical Genetics. 15, 13 p., 2.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia

Schizophrenia Working Group of the Psychiatric Genomics Consortium & Bipolar Disorders Working Group of the Psychiatric Genomics Consortium, 20/06/2017, In: Translational Psychiatry. 7, 6, 9 p., e1155.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness

Schizophrenia Working Group of the Psychiatric Genomics Consortium, 03/2016, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 171B, 2, p. 276-89 14 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Genome-wide mapping of human loci for essential hypertension

Caulfield, M., Munroe, P., Pembroke, J., Samani, N., Dominiczak, A., Brown, M., Benjamin, N., Webster, J., Ratcliffe, P., O'Shea, S., Papp, J., Taylor, E., Dobson, R., Knight, J., Newhouse, S., Hooper, J., Lee, W., Brain, N., Clayton, D., Lathrop, G. M., & 3 othersFarrall, M., Connell, J. & MRC British Genetics of Hypertension Study, 21/06/2003, In: The Lancet. 361, 9375, p. 2118-2123 6 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium, 14/06/2018, In: Cell. 173, 7, p. 1705-1715.e16 11 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Cross-Disorder Group of the Psychiatric Genomics Consortium. Electronic address: plee0@mgh.harvard.edu, 12/12/2019, In: Cell. 179, 7, p. 1469-1482.e11 14 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Genomics implicates adaptive and innate immunity in Alzheimer’s and Parkinson’s diseases

Gagliano, S. A., Pouget, J. G., Hardy, J., Knight, J., Barnes, M. R., Ryten, M. & Weale, M., 12/2016, In: Annals of Clinical and Translational Neurology. 3, 12, p. 924-933 10 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Genotyping, characterization, and imputation of known and novel CYP2A6 structural variants using SNP array data

Langlois, A. W. R., El-Boraie, A., Pouget, J. G., Cox, L. S., Ahluwalia, J. S., Fukunaga, K., Mushiroda, T., Knight, J., Chenoweth, M. J. & Tyndale, R. F., 31/08/2023, In: Journal of Human Genetics . 68, p. 533-541 9 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores

M.R.C.Psych & Schizophrenia Working Group of the Psychiatric Genomics Consortium, 1/08/2019, In: American Journal of Psychiatry. 176, 8, p. 651-660 10 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Haplotype analysis of SNAP-25 suggests a role in the aetiology of ADHD

Mill, J., Richards, S., Knight, J., Curran, S., Taylor, E. & Asherson, P., 08/2004, In: Molecular Psychiatry. 9, 8, p. 801-810 10 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Haplotype and linkage disequilibrium analysis to characterise a region in the calcium channel gene CACNA1A associated with idiopathic generalised epilepsy

Chioza, B., Osei-Lah, A., Nashef, L., Suarez-Merino, B., Wilkie, H., Sham, P., Knight, J., Asherson, P. & Makoff, A. J., 12/2002, In: European Journal of Human Genetics. 10, 12, p. 857-864 8 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Haplotype association analysis of discrete and continuous traits using mixture of regression models

Sham, P. C., Rijsdijk, F. V., Knight, J., Makoff, A., North, B. & Curtis, D., 03/2004, In: Behavior Genetics. 34, 2, p. 207-214 8 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Heritability estimates of cortical anatomy: The influence and reliability of different estimation strategies

Patel, S., Patel, R., Park, M. T. M., Masellis, M., Knight, J. & Chakravarty, M. M., 09/2018, In: NeuroImage. 178, p. 78-91 14 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Heritability of hippocampal subfield volumes using a twin and non-twin siblings design

Patel, S., Park, M. T. M., Devenyi, G. A., Patel, R., Masellis, M., Knight, J. & Chakravarty, M. M., 09/2017, In: Human Brain Mapping. 38, 9, p. 4337-4352 16 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Homing in on depression genes

McGuffin, P., Cohen, S. & Knight, J., 02/2007, In: American Journal of Psychiatry. 164, 2, p. 195-197 3 p.

Research output: Contribution to Journal/Magazine › Editorial › peer-review

Human chromosome 17 in essential hypertension

Knight, J., Munroe, P. B., Pembroke, J. C. & Caulfield, M. J., 03/2003, In: Annals of Human Genetics. 67, 2, p. 193-206 14 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review