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Research

Dr Jonathan Higham

Senior Research Associate

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  1. 2024
  2. Published

    Evergene: an interactive webtool for large-scale gene-centric analysis of primary tumours

    Kennedy, A., Richardson, E., Higham, J., Kotsantis, P., Mort, R. & Shih, B. B.-J., 28/06/2024, In: Bioinformatics advances. 4, 1, vbae092.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. 2022
  4. Published

    Local CpG density affects the trajectory and variance of age-associated DNA methylation changes

    Higham, J., Kerr, L., Zhang, Q., Walker, R. M., Harris, S. E., Howard, D. M., Hawkins, E. L., Sandu, A.-L., Steele, J. D., Waiter, G. D., Murray, A. D., Evans, K. L., McIntosh, A. M., Visscher, P. M., Deary, I. J., Cox, S. R. & Sproul, D., 17/10/2022, In: Genome Biology. 23, 216.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. 2021
  6. Published

    An epigenetic predictor of death captures multi-modal measures of brain health

    Hillary, R. F., Stevenson, A. J., Cox, S. R., McCartney, D. L., Harris, S. E., Seeboth, A., Higham, J., Sproul, D., Taylor, A. M., Redmond, P., Corley, J., Pattie, A., Hernández, M. C. V., Muñoz-Maniega, S., Bastin, M. E., Wardlaw, J. M., Horvath, S., Ritchie, C. W., Spires-Jones, T. L. & McIntosh, A. M. & 3 others, Evans, K. L., Deary, I. J. & Marioni, R. E., 31/08/2021, In: Molecular Psychiatry. 2, p. 3806-3816 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. Published

    De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands

    Masalmeh, R. H. A., Taglini, F., Rubio-Ramon, C., Musialik, K. I., Higham, J., Davidson-Smith, H., Kafetzopoulos, I., Pawlicka, K. P., Finan, H. M., Clark, R., Wills, J., Finch, A. J., Murphy, L. & Sproul, D., 29/01/2021, In: Nature Communications. 12, 1, 694.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. 2020
  9. Published

    Entropy of proteins using multiscale cell correlation

    Chakravorty, A., Higham, J. & Henchman, R. H., 23/11/2020, In: Journal of Chemical Information and Modeling. 60, 11, p. 5540-5551 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    Comparison of Free-Energy Methods to Calculate the Barriers for the Nucleophilic Substitution of Alkyl Halides by Hydroxide

    Ali, H. S., Higham, J., De Visser, S. P. & Henchman, R. H., 6/08/2020, In: Journal of Physical Chemistry B. 124, 31, p. 6835-6842 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  11. Published

    Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation

    Patani, H., Rushton, M. D., Higham, J., Teijeiro, S. A., Oxley, D., Cutillas, P., Sproul, D. & Ficz, G., 22/07/2020, In: Nature Communications. 11, 3671.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  12. 2019
  13. Published

    Age-related clonal haemopoiesis is associated with increased epigenetic age

    Robertson, N. A., Hillary, R. F., McCartney, D. L., Terradas-Terradas, M., Higham, J., Sproul, D., Deary, I. J., Kirschner, K., Marioni, R. E. & Chandra, T., 19/08/2019, In: Current Biology. 29, 16, p. R786-R787 2 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  14. Published

    Entropy of Simulated Liquids Using Multiscale Cell Correlation

    Ali, H. S., Higham, J. & Henchman, R. H., 31/07/2019, In: Entropy. 21, 8, 750.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  15. Published

    De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands

    Ali Masalmeh, R. H., Rubio-Ramon, C., Taglini, F., Higham, J., Davidson-Smith, H., Clark, R., Wills, J., Finch, A. J., Murphy, L. & Sproul, D., 21/06/2019, bioRxiv.

    Research output: Working paper › Preprint

  16. 2018
  17. Published

    Genotype effects contribute to variation in longitudinal methylome patterns in older people

    Zhang, Q., Marioni, R. E., Robinson, M. R., Higham, J., Sproul, D., Wray, N. R., Deary, I. J., McRae, A. F. & Visscher, P. M., 22/10/2018, In: Genome Medicine. 10, 75.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  18. Published

    Entropy of flexible liquids from hierarchical force–torque covariance and coordination

    Higham, J., Chou, S.-Y., Gräter, F. & Henchman, R. H., 31/08/2018, In: Molecular Physics. 116, 15-16, p. 1965-1976 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  19. Published

    Overcoming the limitations of cutoffs for defining atomic coordination in multicomponent systems

    Higham, J. & Henchman, R. H., 5/05/2018, In: Journal of Computational Chemistry. 39, 12, p. 705-710 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  20. 2016
  21. Published

    Locally adaptive method to define coordination shell

    Higham, J. & Henchman, R. H., 28/08/2016, In: Journal of Chemical Physics. 145, 8, 084108.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  22. Published

    Parameter-Free Hydrogen-Bond Definition to Classify Protein Secondary Structure

    Haghighi, H., Higham, J. & Henchman, R. H., 25/08/2016, In: Journal of Physical Chemistry B. 120, 33, p. 8566-8570 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  23. 2015
  24. Published

    Instantaneous, parameter-free methods to define a solute's hydration shell

    Chatterjee, A., Higham, J. & Henchman, R. H., 21/12/2015, In: Journal of Chemical Physics. 143, 23, 234501.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  25. Published

    A New Algorithm to Diagnose Atrial Ectopic Origin from Multi Lead ECG Systems - Insights from 3D Virtual Human Atria and Torso

    Alday, E. A. P., Colman, M. A., Langley, P., Butters, T. D., Higham, J., Workman, A. J., Hancox, J. C. & Zhang, H., 22/01/2015, In: PLoS Computational Biology. 11, 1, e1004026.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  26. 2014
  27. Published

    Diagnosis of atrial ectopic origin from the body surface ECG: Insights from 3D virtual human atria and torso

    Perez Alday, E. A., Colman, M. A., Butters, T. D., Higham, J., Giacopelli, D., Langley, P. & Zhang, H., 16/01/2014, Computing in Cardiology 2013. IEEE

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Conference contribution/Paper › peer-review

  28. 2012
  29. Published

    Modeling the chronotropic effect of isoprenaline on rabbit sinoatrial node

    Zhang, H., Butters, T., Adeniran, I., Higham, J., Holden, A. V., Boyett, M. R. & Hancox, J. C., 9/07/2012, In: Frontiers in Physiology. 3, 241.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  30. Published

    Large speed increase using novel GPU based algorithms to simulate cardiac excitation waves in 3D rabbit ventricles

    Higham, J., Aslanidi, O. & Zhang, H., 9/03/2012, 2011 Computing in Cardiology. IEEE

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Conference contribution/Paper › peer-review

  31. 2011
  32. Published

    Mitogen-activated protein kinase kinase 4 deficiency in cardiomyocytes causes connexin 43 reduction and couples hypertrophic signals to ventricular arrhythmogenesis

    Zi, M., Kimura, T. E., Liu, W., Jin, J., Higham, J., Kharche, S., Hao, G., Shi, Y., Shen, W., Prehar, S., Mironov, A., Neyses, L., Bierhuizen, M. F. A., Boyett, M. R., Zhang, H., Lei, M., Cartwright, E. J. & Wang, X., 20/05/2011, In: Journal of Biological Chemistry. 286, 20, p. 17821-17830 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  33. Published

    Anti-arrhythmic effects of atrial specific IKur block: A simulation study

    Law, P., Kharche, S., Higham, J. & Zhang, H., 22/03/2011, 2010 Computing in Cardiology. IEEE

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Conference contribution/Paper › peer-review

  34. Published

    Functional roles of ionic currents in a membrane delimited mouse sino-atrial node model

    Kharche, S., Higham, J., Lei, M. & Zhang, H., 22/03/2011, 2010 Computing in Cardiology. IEEE, Vol. 37. p. 421-424 4 p. 5737999

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Conference contribution/Paper › peer-review

  35. 2008
  36. Published

    High performance stream computing for particle beam transport simulations

    Appleby, R., Bailey, D., Higham, J. & Salt, M., 2008, In: Journal of Physics: Conference Series. 119, 042001.

    Research output: Contribution to Journal/Magazine › Conference article › peer-review

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