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Research

Dr Lorna Ashton

Senior Lecturer

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  1. 2005
  2. Published

    Monitoring the mode of action of antibiotics using Raman spectroscopy: investigating subinhibitory effects of amikacin on Pseudomonas aeruginosa

    López-Diez, E. C., Winder, C. L., Ashton, L., Currie, F. & Goodacre, R., 1/05/2005, In: Analytical Chemistry. 77, 9, p. 2901-2906 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. 2006
  4. Published

    Two-dimensional correlation analysis of Raman optical activity data on the α-helix-to-β-sheet transition in poly(L-lysine)

    Ashton, L., Barron, L. D., Czarnik-matusewicz, B., Hecht, L., Hyde, J. & Blanch, E. W., 10/05/2006, In: Molecular Physics. 104, 9, p. 1429-1445 17 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. Published

    Application of two-dimensional correlation analysis to Raman optical activity

    Ashton, L., Czarnik-Matusewicz, B. & Blanch, E. W., 6/11/2006, In: Journal of Molecular Structure. 799, 1-3, p. 61-71 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. Published

    Potential pitfalls concerning visualization of the 2D results

    Czarnik-Matusewicz, B., Pilorz, S., Ashton, L. & Blanch, E. W., 6/11/2006, In: Journal of Molecular Structure. 799, 1-3, p. 253-258 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. 2007
  8. Published

    Two-dimensional Raman and Raman optical activity correlation analysis of the alpha-helix-to-disordered transition in poly(L-glutamic acid)

    Ashton, L., Barron, L. D., Hecht, L., Hyde, J. & Blanch, E. W., 05/2007, In: Analyst. 132, 5, p. 468-479 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. 2008
  10. Published

    Investigation of polypeptide conformational transitions with two-dimensional Raman optical activity correlation analysis, applying autocorrelation and moving window approaches

    Ashton, L. & Blanch, E. W., 05/2008, In: Applied Spectroscopy. 62, 5, p. 469-475 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  11. Published

    Investigations of conformational transitions in proteins and RNA using 2DCOS Raman and 2DCOS Raman optical activity spectroscopies

    Ashton, L., Hobro, A., Conn, G. L., Rouhi, M. & Blanch, E. W., 30/07/2008, In: Journal of Molecular Structure. 883-884, p. 187-194 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  12. 2009
  13. Published

    Shear-induced unfolding of lysozyme monitored in situ

    Ashton, L., Dusting, J., Imomoh, E., Balabani, S. & Blanch, E. W., 20/05/2009, In: Biophysical Journal. 96, 10, p. 4231-4236 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  14. 2010
  15. Published

    Susceptibility of different proteins to flow-induced conformational changes monitored with Raman spectroscopy

    Ashton, L., Dusting, J., Imomoh, E., Balabani, S. & Blanch, E. W., 17/02/2010, In: Biophysical Journal. 98, 4, p. 707-714 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  16. Published

    pH-induced conformational transitions in alpha-lactalbumin investigated with two-dimensional Raman correlation variance plots and moving windows

    Ashton, L. & Blanch, E. W., 16/06/2010, In: Journal of Molecular Structure. 974, 1-3, p. 132-138 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  17. 2011
  18. Published

    Structural, spectroscopic and redox properties of uranyl complexes with a maleonitrile containing ligand

    Hardwick, H. C., Royal, D. S., Helliwell, M., Pope, S. J. A., Ashton, L., Goodacre, R. & Sharrad, C. A., 2011, In: Dalton Transactions. 40, 22, p. 5939-5952 14 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  19. Published

    Monitoring the glycosylation status of proteins using Raman spectroscopy

    Brewster, V. L., Ashton, L. & Goodacre, R., 1/08/2011, In: Analytical Chemistry. 83, 15, p. 6074-6081 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  20. Published

    Raman spectroscopy: lighting up the future of microbial identification

    Ashton, L., Lau, K., Winder, C. L. & Goodacre, R., 09/2011, In: Future Microbiology. 6, 9, p. 991-997 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  21. Published

    The importance of protonation in the investigation of protein phosphorylation using Raman spectroscopy and Raman optical activity

    Ashton, L., Johannessen, C. & Goodacre, R., 15/10/2011, In: Analytical Chemistry. 83, 20, p. 7978-7983 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  22. 2013
  23. Published

    Illuminating disease and enlightening biomedicine: Raman spectroscopy as a diagnostic tool

    Ellis, D. I., Cowcher, D. P., Ashton, L., O'Hagan, S. & Goodacre, R., 2013, In: Analyst. 138, 14, p. 3871-3884 14 p.

    Research output: Contribution to Journal/Magazine › Literature review › peer-review

  24. Published

    Monitoring Guanidinium-Induced Structural Changes in Ribonuclease Proteins Using Raman Spectroscopy and 2D Correlation Analysis

    Brewster, V. L., Ashton, L. & Goodacre, R., 2/04/2013, In: Analytical Chemistry. 85, 7, p. 3570-3575 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  25. Published

    The challenge of applying Raman spectroscopy to monitor recombinant antibody production

    Ashton, L., Xu, Y., Brewster, V. L., Cowcher, D. P., Sellick, C. A., Dickson, A. J., Stephens, G. M. & Goodacre, R., 26/09/2013, In: Analyst. 138, 22, p. 6977-6985 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  26. Published

    Understanding glycoprotein behaviours using Raman and Raman optical activity spectroscopies: characterising the entanglement induced conformational changes in oligosaccharide chains of mucin

    Ashton, L., Pudney, P. D. A., Blanch, E. W. & Yakubov, G. E., 11/2013, In: Advances in Colloid and Interface Science. 199-200, p. 66-77 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  27. 2014
  28. Published

    Raman spectroscopy can characterise the early stages of osteoinduction in dental pulp stromal cells

    Mighell, A., Ashton, L., Yang, X., Smith, A. & Kirkham, J., 06/2014, In: Journal of Tissue Engineering and Regenerative Medicine. 8, Supplement 1, p. 303-303 1 p.

    Research output: Contribution to Journal/Magazine › Meeting abstract › peer-review

  29. Published

    Investigation of DMSO-induced conformational transitions in human serum albumin using two-dimensional Raman optical activity spectroscopy

    Batista, A. N. L., Batista, J. M., Ashton, L., Bolzani, V. S., Furlan, M. & Blanch, E. W., 09/2014, In: Chirality. 26, 9, p. 497-501 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  30. Published

    Monitoring antibody aggregation in early drug development using Raman spectroscopy and perturbation-correlation moving windows

    Gómez de la Cuesta, R., Goodacre, R. & Ashton, L., 18/11/2014, In: Analytical Chemistry. 86, 22, p. 11133-11140 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  31. 2015
  32. Published

    Detection of early stage changes associated with adipogenesis using Raman spectroscopy under aseptic conditions

    Mitchell, A., Ashton, L., Yang, X. B., Goodacre, R., Smith, A. & Kirkham, J., 2015, In: Cytometry Part A. 87, 11, p. 1012-1019 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  33. Published

    UV resonance Raman spectroscopy: a process analytical tool for host cell DNA and RNA dynamics in mammalian cell lines

    Ashton, L., Hogwood, C. E. M., Tait, A. S., Kuligowski, J., Smales, C. M., Bracewell, D. G., Dickson, A. J. & Goodacre, R., 02/2015, In: Journal of Chemical Technology and Biotechnology. 90, 2, p. 237-243 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  34. Published

    Making colourful sense of Raman images of single cells

    Ashton, L., Hollyowood, K. & Goodacre, R., 21/03/2015, In: Analyst. 140, 6, p. 1852-1858 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  35. Published

    Aseptic Raman spectroscopy can detect changes associated with the culture of human dental pulp stromal cells in osteoinductive culture

    Mitchell, A., Ashton, L., Yang, X. B., Goodacre, R., Tomlinson, M. J., Smith, A. & Kirkham, J., 10/09/2015, In: The Analyst. 140, 21, p. 7347-7354 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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