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Research

Dr Rachael Rigby

Formerly at Lancaster University

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  1. Published

    Loop ileostomy-mediated fecal stream diversion is associated with microbial dysbiosis

    Beamish, E., Johnson, J., Shaw, E., Scott, N. A., Bhowmick, A. & Rigby, R. J., 3/09/2017, In: Gut Microbes. 8, 5, p. 467-478 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  2. Published

    Delay in loop ileostomy reversal surgery does not impact upon post-operative clinical outcomes. Complications are associated with an increased loss of microflora in the defunctioned intestine

    Beamish, E. L., Johnson, J., Shih, B., Killick, R., Dondelinger, F., McGoran, C., Brewster-Craig, C., Davies, A., Bhowmick, A. & Rigby, R. J., 31/12/2023, In: Gut Microbes. 15, 1, 2199659.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. Published

    Migration and maturation of human colonic dendritic cells

    Bell, S. J., Rigby, R., English, N., Mann, S. D., Knight, S. C., Kamm, M. A. & Stagg, A. J., 15/04/2001, In: Journal of Immunology. 166, 8, p. 4958-4967 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. Published

    Bacterial-dependent up-regulation of intestinal bile acid binding protein and transport is FXR-mediated following ileo-cecal resection

    Dekaney, C. M., von Allmen, D. C., Garrison, A. P., Rigby, R. J., Lund, P. K., Henning, S. J. & Helmrath, M. A., 08/2008, In: Surgery. 144, 2, p. 174-181 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. Published

    Expansion of intestinal stem cells associated with long-term adaptation following ileocecal resection in mice

    Dekaney, C. M., Fong, J. J., Rigby, R. J., Lund, P. K., Henning, S. J. & Helmrath, M. A., 11/2007, In: American Journal of Physiology-Gastrointestinal and Liver Physiology. 293, 5, p. G1013-G1022 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. Published

    High-Fat Diet: Bacteria Interactions Promote Intestinal Inflammation Which Precedes and Correlates with Obesity and Insulin Resistance in Mouse

    Ding, S., Chi, M. M., Scull, B. P., Rigby, R., Schwerbrock, N. M. J., Magness, S., Jobin, C. & Lund, P. K., 16/08/2010, In: PLoS ONE. 5, 8, p. - 13 p., e12191.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. Published

    Characteristics of intestinal dendritic cells in inflammatory bowel diseases

    Hart, A. L., Al-Hassi, H. O., Rigby, R. J., Bell, S. J., Emmanuel, A. V., Knight, S. C., Kamm, M. A. & Stagg, A. J., 07/2005, In: Gastroenterology. 129, 1, p. 50-65 16 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. Published

    A hierarchical Bayesian approach for detecting global microbiome associations

    Hatami, F., Beamish, E., Davies, A., Rigby, R. & Dondelinger, F., 1/11/2021, In: Statistical Applications in Genetics and Molecular Biology. 20, 3, p. 85-100 16 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. Published

    Cannabinoid-induced autophagy regulates suppressor of cytokine signaling (SOCS)-3 in intestinal epithelium

    Koay, L., Rigby, R. & Wright, K., 15/07/2014, In: American Journal of Physiology-Gastrointestinal and Liver Physiology. 307, p. G140-G148 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    What Are the Mechanisms of Fibrosis in IBD?

    Lund, P. K. & Rigby, R. J., 10/2008, In: Inflammatory Bowel Diseases. 14, Supplement 2, p. S127-S128 2 p.

    Research output: Contribution to Journal/Magazine › Letter › peer-review

  11. Published

    SOC-ing it to tumors: suppressors of cytokine signaling as tumor repressors

    Lund, P. K. & Rigby, R. J., 07/2006, In: Gastroenterology. 131, 1, p. 317-319 3 p.

    Research output: Contribution to Journal/Magazine › Editorial › peer-review

  12. Published

    Human gut dendritic cells drive aberrant gut-specific T-cell responses in ulcerative colitis, characterized by increased IL-4 production and loss of IL-22 and IFNγ

    Mann, E. R., Bernardo, D., Ng, S. C., Rigby, R. J., Al-hassi, H. O., Landy, J., Peake, S. T. C., Spranger, H., English, N. R., Thomas, L. V., Stagg, A. J., Knight, S. C. & Hart, A. L., 1/12/2014, In: Inflammatory Bowel Diseases. 20, 12, p. 2299-2307 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  13. Published

    Hypothesis: Bacterial induced inflammation disrupts the orderly progression of the stem cell hierarchy and has a role in the pathogenesis of breast cancer

    Marwaha, A. K., Morris, J. A. & Rigby, R. J., 31/03/2020, In: Medical Hypotheses. 136, 5 p., 109530.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  14. Published

    SARS-CoV-2 Interacts with Mucosal Dysbiosis to Cause the Wide Range of Disease Seen in Covid-19

    Morris, J., Shepherd, R., Wray, M., Diep, P-T. & Rigby, R., 26/03/2022, In: Austin Journal of Pulmonary and Respiratory Medicine. 9, 1, 7 p., 1086.

    Research output: Contribution to Journal/Magazine › Review article › peer-review

  15. Published

    A new animal model of postsurgical bowel inflammation and fibrosis: the effect of commensal microflora

    Rigby, R. J., Hunt, M. R., Scull, B. P., Simmons, J. G., Speck, K. E., Helmrath, M. A. & Lund, P. K., 08/2009, In: Gut. 58, 8, p. 1104-1112 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  16. Published

    Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon

    Rigby, R. J., Simmons, J. G., Greenhalgh, C. J., Alexander, W. S. & Lund, P. K., 19/07/2007, In: Oncogene. 26, 33, p. 4833-4841 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  17. Published

    Production of interleukin (IL)-10 and IL-12 by murine colonic dendritic cells in response to microbial stimuli

    Rigby, R. J., Knight, S. C., Kamm, M. A. & Stagg, A. J., 02/2005, In: Clinical and Experimental Immunology. 139, 2, p. 245-256 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  18. Published

    Intestinal bacteria are necessary for doxorubicin-induced intestinal damage but not for doxorubicin-induced apoptosis

    Rigby, R. J., Carr, J., Orgel, K., King, S. L., Lund, P. K. & Dekaney, C. M., 09/2016, In: Gut Microbes. 7, 5, p. 414-423 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  19. Published

    Intestinal Epithelial Cell (IEC)-Specific Deletion of Suppressor of Cytokine Signaling 3 (SOCS3) in Interleukin-10 Null Mice Promotes Duodenal Tumors Independent of Inflammation: Detection with a Cathepsin-B Activatable Molecular Probe

    Scull, B., Rigby, R. J., Newton, V. A., Hamilton, K., Morgan, D. & Lund, P. K., 05/2009, In: Gastroenterology. 136, 5 Supplement 1, p. A114-A114 1 p., 718.

    Research output: Contribution to Journal/Magazine › Special issue › peer-review

  20. Published

    Suppressor of cytokine signalling three regulated intestinal epithelial cell turnover: impact on microbial resistance

    Shaw, E., Else, K. & Rigby, R., 2014.

    Research output: Contribution to conference - Without ISBN/ISSN › Poster › peer-review

  21. Published

    Suppressor of Cytokine signalling 3 (socs3) impacts on intestinal epithelial cell proliferation during intestinal helminth infection

    Shaw, E., Else, K. & Rigby, R., 06/2014.

    Research output: Contribution to conference - Without ISBN/ISSN › Abstract › peer-review

  22. Published

    Intestinal epithelial suppressor of cytokine signaling 3 (SOCS3) impacts on mucosal homeostasis in a model of chronic inflammation.

    Shaw, E. J., Smith, E., Whittingham-Dowd, J. K., Hodges, M. D. J., Else, K. J. & Rigby, R. J., 09/2017, In: Immunity, Inflammation and Disease. 5, 3, p. 336-345 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  23. Published

    Inflammation Enhances Resection-Induced Intestinal Adaptive Growth in IL-10 Null Mice

    Speck, K. E., Garrison, A. P., Rigby, R. J., von Allmen, D. C., Lund, P. K. & Helmrath, M. A., 1/06/2011, In: Journal of Surgical Research. 168, 1, p. 62-69 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  24. Published

    The role of suppressor of cytokine signalling 3 in regulating TLR-mediated intestinal epithelial cell homeostasis and repair

    Thagia, I. & Rigby, R., 12/2010, In: Clinical and Experimental Immunology. 131, p. 124-125 2 p.

    Research output: Contribution to Journal/Magazine › Special issue › peer-review

  25. Published

    Intestinal epithelial Suppressor of Cytokine Signaling (SOCS) 3 enhances microbial induced inflammatory TNFα, contributing to epithelial barrier dysfunction

    Thagia, I., Shaw, E. J., Smith, E., Else, K. J. & Rigby, R. J., 1/01/2015, In: American Journal of Physiology-Gastrointestinal and Liver Physiology. 308, 1, p. G25-G31 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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