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Dr Stefanie Menzies

Lecturer in Molecular Cell Biology

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  1. Published

    A broadly active fucosyltransferase LmjFUT1 whose mitochondrial localization and activity are essential in parasitic Leishmania

    Guo, H., Damerow, S., Penha, L., Menzies, S., Polanco, G., Zegzouti, H., Ferguson, M. A. J. & Beverley, S. M., 17/08/2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 33, e2108963118.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  2. Published

    ADDovenom: Thermostable Protein-Based ADDomer Nanoparticles as New Therapeutics for Snakebite Envenoming

    Menzies, S. K., Arinto-Garcia, R., Amorim, F. G., Cardoso, I. A., Abada, C., Crasset, T., Durbesson, F., Edge, R. J., El-Kazzi, P., Hall, S., Redureau, D., Stenner, R., Boldrini-França, J., Sun, H., Roldão, A., Alves, P. M., Harrison, R. A., Vincentelli, R., Berger, I. & Quinton, L. & 2 others, Casewell, N. R. & Schaffitzel, C., 28/11/2023, In: Toxins. 15, 12, 673.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. E-pub ahead of print

    African polyvalent antivenom can maintain pharmacological stability and ability to neutralise murine venom lethality for decades post-expiry: Evidence for increasing antivenom shelf life to aid in alleviating chronic shortages

    Solano, G., Cunningham, S., Edge, R. J., Duran, G., Sanchez, A., Villalta, M., Clare, R. H., Wilkinson, M. C., Marriott, A. E., Abada, C., Menzies, S. K., Keen, M., Lalloo, D. G., Stienstra, Y., Abouyannis, M., Casewell, N. R., León, G. & Ainsworth, S., 13/03/2024, (E-pub ahead of print) In: BMJ Global Health. 9, 3, e014813.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. Published

    An analysis of preclinical efficacy testing of antivenoms for sub-Saharan Africa: Inadequate independent scrutiny and poor-quality reporting are barriers to improving snakebite treatment and management

    Ainsworth, S., Menzies, S. K., Casewell, N. R. & Harrison, R. A., 20/08/2020, In: PLoS Neglected Tropical Diseases. 14, 8, p. 1-25 25 p., e0008579.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. Published

    De novo designed proteins neutralize lethal snake venom toxins

    Vázquez Torres, S., Benard Valle, M., Mackessy, S. P., Menzies, S. K., Casewell, N. R., Ahmadi, S., Burlet, N. J., Muratspahić, E., Sappington, I., Overath, M. D., Rivera-de-Torre, E., Ledergerber, J., Laustsen, A. H., Boddum, K., Bera, A. K., Kang, A., Brackenbrough, E., Cardoso, I. A., Crittenden, E. P. & Edge, R. J. & 12 others, Decarreau, J., Ragotte, R. J., Pillai, A. S., Abedi, M., Han, H. L., Gerben, S. R., Murray, A., Skotheim, R., Stuart, L., Stewart, L., Fryer, T. J. A. & Jenkins, T. P., 6/03/2025, In: Nature. 639, p. 225-231 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. Published

    Design and Synthesis of Broad Spectrum Trypanosomatid Selective Inhibitors

    Fraser, A. L., Menzies, S. K., King, E. F. B., Tulloch, L. B., Gould, E. R., Zacharova, M. K., Smith, T. K. & Florence, G. J., 13/04/2018, In: ACS Infectious Diseases. 4, 4, p. 560-567 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. Published

    Development of Simplified Heterocyclic Acetogenin Analogues as Potent and Selective Trypanosoma brucei Inhibitors

    Florence, G. J., Fraser, A. L., Gould, E. R., King, E. F., Menzies, S. K., Morris, J. C., Thomson, M. I., Tulloch, L. B., Zacharova, M. K. & Smith, T. K., 19/07/2016, In: ChemMedChem. 11, 14, p. 1503-1506 4 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. Published

    Direct and indirect approaches to identify drug modes of action

    Tulloch, L. B., Menzies, S. K., Coron, R. P., Florence, G. J. & Smith, T. K., 1/01/2018, In: IUBMB Life. 70, 1, p. 9-22 14 p.

    Research output: Contribution to Journal/Magazine › Review article › peer-review

  9. Published

    Exploring the Utility of Recombinant Snake Venom Serine Protease Toxins as Immunogens for Generating Experimental Snakebite Antivenoms

    Alomran, N., Blundell, P., Alsolaiss, J., Crittenden, E., Ainsworth, S., Dawson, C. A., Edge, R. J., Hall, S. R., Harrison, R. A., Wilkinson, M. C., Menzies, S. K. & Casewell, N. R., 29/06/2022, In: Toxins. 14, 7, 443.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    Igg seroconversion and pathophysiology in severe acute respiratory syndrome coronavirus 2 infection

    Staines, H. M., Kirwan, D. E., Clark, D. J., Augustin, Y., Byrne, R. L., Cocozza, M., Cubas-Atienzar, A. I., Cuevas, L. E., Cusinato, M., Davies, B. M. O., Davis, M., Davis, P., Duvoix, A., Eckersley, N. M., Forton, D., Fraser, A. J., Garrod, G., Hadcocks, L., Hu, Q. & Kay, G. A. & 18 others, Klekotko, K., Lewis, Z., Macallan, D. C., Mensah-Kane, J., Menzies, S., Monahan, I., Moore, C. M., Nebe-Von-Caron, G., Owen, S. I., Sainter, C., Sall, A. A., Schouten, J., Williams, C. T., Wilkins, J., Woolston, K., Fitchett, J. R. A., Krishna, S. & Planche, T., 31/01/2021, In: Emerging Infectious Diseases. 27, 1, p. 85-91 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  11. Published

    In vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus

    Menzies, S. K., Clare, R. H., Xie, C., Westhorpe, A., Hall, S. R., Edge, R. J., Alsolaiss, J., Crittenden, E., Marriott, A. E., Harrison, R. A., Kool, J. & Casewell, N. R., 18/03/2022, In: Toxicon: X. 14, p. 100118

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  12. Published

    Livestock herding and fulani ethnicity are a combined risk factor for development of early adverse reactions to antivenom treatment: Findings from a cross-sectional study in Nigeria

    Menzies, S. K., Thomas, A. O., Tianyi, F. L., Abubakar, S. B., Nasidi, A., Durfa, N., Patel, R., Trelfa, A., Lalloo, D. G., Habib, A. G. & Harrison, R. A., 12/08/2021, In: PLoS Neglected Tropical Diseases. 15, 8, e0009518.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  13. Published

    Next-Generation Sequencing for Venomics: Application of Multi-Enzymatic Limited Digestion for Inventorying the Snake Venom Arsenal

    Amorim, F. G., Redureau, D., Crasset, T., Freuville, L., Baiwir, D., Mazzucchelli, G., Menzies, S. K., Casewell, N. R. & Quinton, L., 25/06/2023, In: Toxins. 15, 6, 357.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  14. Published

    Non-natural Acetogenin Analogues as Potent Trypanosoma brucei Inhibitors

    Florence, G. J., Fraser, A. L., Gould, E. R., King, E. F. B., Menzies, S. K., Morris, J. C., Tulloch, L. B. & Smith, T. K., 1/11/2014, In: ChemMedChem. 9, 11, p. 2548-2556 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  15. Published

    Photo-affinity labelling and biochemical analyses identify the target of trypanocidal simplified natural product analogues

    Tulloch, L. B., Menzies, S. K., Fraser, A. L., Gould, E. R., King, E. F., Zacharova, M. K., Florence, G. J. & Smith, T. K., 5/09/2017, In: PLoS Neglected Tropical Diseases. 11, 9, e0005886.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  16. E-pub ahead of print

    Practical progress towards the development of recombinant antivenoms for snakebite envenoming

    Menzies, S., Patel, R. N. & Ainsworth, S., 29/04/2025, (E-pub ahead of print) In: Expert Opinion on Drug Discovery.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  17. Published

    Risk Factors for Soil-Transmitted Helminth Infections during the First 3 Years of Life in the Tropics; Findings from a Birth Cohort

    Menzies, S. K., Rodriguez, A., Chico, M., Sandoval, C., Broncano, N., Guadalupe, I. & Cooper, P. J., 27/02/2014, In: PLoS Neglected Tropical Diseases. 8, 2, e2718.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  18. Published

    Saliva alternative to upper respiratory swabs for SARS-CoV-2 diagnosis

    Byrne, R. L., Kay, G. A., Kontogianni, K., Aljayyoussi, G., Brown, L., Collins, A. M., Cuevas, L. E., Ferreira, D. M., Fletcher, T., Fraser, A. J., Garrod, G., Hill, H., Hughes, G. L., Menzies, S., Mitsi, E., Owen, S. I., Patterson, E. I., Todd, S., Williams, C. T. & Hyder-Wright, A. & 2 others, Adams, E. R. & Cubas-Atienzar, A. I., 11/11/2020, In: Emerging Infectious Diseases. 26, 11, p. 2769-2770 2 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  19. Published

    Self-sampling of capillary blood for SARS-CoV-2 serology

    Brown, L., Byrne, R. L., Fraser, A., Owen, S. I., Cubas-Atienzar, A. I., Williams, C. T., Kay, G. A., Cuevas, L. E., Fitchett, J. R. A., Fletcher, T., Garrod, G., Kontogianni, K., Krishna, S., Menzies, S., Planche, T., Sainter, C., Staines, H. M. & Turtle, L., 8/04/2021, In: Scientific Reports. 11, 1, 7754.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  20. Published

    Simplifying nature: Towards the design of broad spectrum kinetoplastid inhibitors, inspired by acetogenins

    Gould, E. R., King, E. F. B., Menzies, S. K., Fraser, A. L., Tulloch, L. B., Zacharova, M. K., Smith, T. K. & Florence, G. J., 15/11/2017, In: Bioorganic and Medicinal Chemistry. 25, 22, p. 6126-6136 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  21. Published

    Structure-Based Design, Synthesis and Biological Evaluation of Bis-Tetrahydropyran Furan Acetogenin Mimics Targeting the Trypanosomatid F1 Component of ATP Synthase

    Zacharova, M. K., Tulloch, L. B., Gould, E. R., Fraser, A. L., King, E. F., Menzies, S. K., Smith, T. K. & Florence, G. J., 1/09/2019, In: European Journal of Organic Chemistry. 2019, 31-32, p. 5434-5440 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  22. Published

    Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins

    Khalek, I. S., Laxme, R. R. S., Nguyen, Y. T. K., Khochare, S., Patel, R. N., Woehl, J., Smith, J. M., Saye-Francisco, K., Kim, Y., Mindrebo, L. M., Tran, Q., Kędzior, M., Boré, E., Limbo, O., Verma, M., Stanfield, R. L., Menzies, S. K., Ainsworth, S., Harrison, R. A. & Burton, D. R. & 5 others, Sok, D., Wilson, I. A., Casewell, N. R., Sunagar, K. & Jardine, J. G., 21/02/2024, In: Science Translational Medicine. 16, 735, eadk1867.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  23. Published

    The trypanosome alternative oxidase: A potential drug target?

    Menzies, S. K., Tulloch, L. B., Florence, G. J. & Smith, T. K., 1/02/2018, In: Parasitology. 145, 2, p. 175-183 9 p.

    Research output: Contribution to Journal/Magazine › Review article › peer-review

  24. Published

    Twelve lateral flow immunoassays (LFAs) to detect SARS-CoV-2 antibodies

    Owen, S. I., Williams, C. T., Garrod, G., Fraser, A. J., Menzies, S., Baldwin, L., Brown, L., Byrne, R. L., Collins, A. M., Cubas-Atienzar, A. I., de Vos, M., Edwards, T., Escadafal, C., Ferreira, D. M., Fletcher, T., Hyder-Wright, A., Kay, G. A., Kontogianni, K., Mason, J. & Mitsi, E. & 7 others, Planche, T., Sacks, J. A., Taylor, J., Todd, S., Tully, C., Cuevas, L. E. & Adams, E. R., 31/03/2022, In: Journal of Infection. 84, 3, p. 355-360 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  25. Published

    Two snakebite antivenoms have potential to reduce Eswatini's dependency upon a single, increasingly unavailable product: Results of preclinical efficacy testing

    Menzies, S. K., Litschka-Koen, T., Edge, R. J., Alsolaiss, J., Crittenden, E., Hall, S. R., Westhorpe, A., Thomas, B., Murray, J., Shongwe, N., Padidar, S., Lalloo, D. G., Casewell, N. R., Pons, J. & Harrison, R. A., 15/09/2022, In: PLoS Neglected Tropical Diseases. 16, 9, e0010496.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  26. Published

    Virus-like particles displaying conserved toxin epitopes stimulate polyspecific, murine antibody responses capable of snake venom recognition

    Menzies, S. K., Dawson, C. A., Crittenden, E., Edge, R. J., Hall, S. R., Alsolaiss, J., Wilkinson, M. C., Casewell, N. R., Harrison, R. A. & Ainsworth, S., 5/07/2022, In: Scientific Reports. 12, 1, p. 11328

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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