Practical progress towards the development of recombinant antivenoms for snakebite envenoming

Menzies, S., Patel, R. N. & Ainsworth, S., 29/04/2025, (E-pub ahead of print) In: Expert Opinion on Drug Discovery.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

De novo designed proteins neutralize lethal snake venom toxins

Vázquez Torres, S., Benard Valle, M., Mackessy, S. P., Menzies, S. K., Casewell, N. R., Ahmadi, S., Burlet, N. J., Muratspahić, E., Sappington, I., Overath, M. D., Rivera-de-Torre, E., Ledergerber, J., Laustsen, A. H., Boddum, K., Bera, A. K., Kang, A., Brackenbrough, E., Cardoso, I. A., Crittenden, E. P. & Edge, R. J. & 12 others, Decarreau, J., Ragotte, R. J., Pillai, A. S., Abedi, M., Han, H. L., Gerben, S. R., Murray, A., Skotheim, R., Stuart, L., Stewart, L., Fryer, T. J. A. & Jenkins, T. P., 6/03/2025, In: Nature. 639, p. 225-231 7 p.

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African polyvalent antivenom can maintain pharmacological stability and ability to neutralise murine venom lethality for decades post-expiry: Evidence for increasing antivenom shelf life to aid in alleviating chronic shortages

Solano, G., Cunningham, S., Edge, R. J., Duran, G., Sanchez, A., Villalta, M., Clare, R. H., Wilkinson, M. C., Marriott, A. E., Abada, C., Menzies, S. K., Keen, M., Lalloo, D. G., Stienstra, Y., Abouyannis, M., Casewell, N. R., León, G. & Ainsworth, S., 13/03/2024, (E-pub ahead of print) In: BMJ Global Health. 9, 3, e014813.

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Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins

Khalek, I. S., Laxme, R. R. S., Nguyen, Y. T. K., Khochare, S., Patel, R. N., Woehl, J., Smith, J. M., Saye-Francisco, K., Kim, Y., Mindrebo, L. M., Tran, Q., Kędzior, M., Boré, E., Limbo, O., Verma, M., Stanfield, R. L., Menzies, S. K., Ainsworth, S., Harrison, R. A. & Burton, D. R. & 5 others, Sok, D., Wilson, I. A., Casewell, N. R., Sunagar, K. & Jardine, J. G., 21/02/2024, In: Science Translational Medicine. 16, 735, eadk1867.

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ADDovenom: Thermostable Protein-Based ADDomer Nanoparticles as New Therapeutics for Snakebite Envenoming

Menzies, S. K., Arinto-Garcia, R., Amorim, F. G., Cardoso, I. A., Abada, C., Crasset, T., Durbesson, F., Edge, R. J., El-Kazzi, P., Hall, S., Redureau, D., Stenner, R., Boldrini-França, J., Sun, H., Roldão, A., Alves, P. M., Harrison, R. A., Vincentelli, R., Berger, I. & Quinton, L. & 2 others, Casewell, N. R. & Schaffitzel, C., 28/11/2023, In: Toxins. 15, 12, 673.

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Next-Generation Sequencing for Venomics: Application of Multi-Enzymatic Limited Digestion for Inventorying the Snake Venom Arsenal

Amorim, F. G., Redureau, D., Crasset, T., Freuville, L., Baiwir, D., Mazzucchelli, G., Menzies, S. K., Casewell, N. R. & Quinton, L., 25/06/2023, In: Toxins. 15, 6, 357.

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Two snakebite antivenoms have potential to reduce Eswatini's dependency upon a single, increasingly unavailable product: Results of preclinical efficacy testing

Menzies, S. K., Litschka-Koen, T., Edge, R. J., Alsolaiss, J., Crittenden, E., Hall, S. R., Westhorpe, A., Thomas, B., Murray, J., Shongwe, N., Padidar, S., Lalloo, D. G., Casewell, N. R., Pons, J. & Harrison, R. A., 15/09/2022, In: PLoS Neglected Tropical Diseases. 16, 9, e0010496.

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Virus-like particles displaying conserved toxin epitopes stimulate polyspecific, murine antibody responses capable of snake venom recognition

Menzies, S. K., Dawson, C. A., Crittenden, E., Edge, R. J., Hall, S. R., Alsolaiss, J., Wilkinson, M. C., Casewell, N. R., Harrison, R. A. & Ainsworth, S., 5/07/2022, In: Scientific Reports. 12, 1, p. 11328

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Exploring the Utility of Recombinant Snake Venom Serine Protease Toxins as Immunogens for Generating Experimental Snakebite Antivenoms

Alomran, N., Blundell, P., Alsolaiss, J., Crittenden, E., Ainsworth, S., Dawson, C. A., Edge, R. J., Hall, S. R., Harrison, R. A., Wilkinson, M. C., Menzies, S. K. & Casewell, N. R., 29/06/2022, In: Toxins. 14, 7, 443.

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Twelve lateral flow immunoassays (LFAs) to detect SARS-CoV-2 antibodies

Owen, S. I., Williams, C. T., Garrod, G., Fraser, A. J., Menzies, S., Baldwin, L., Brown, L., Byrne, R. L., Collins, A. M., Cubas-Atienzar, A. I., de Vos, M., Edwards, T., Escadafal, C., Ferreira, D. M., Fletcher, T., Hyder-Wright, A., Kay, G. A., Kontogianni, K., Mason, J. & Mitsi, E. & 7 others, Planche, T., Sacks, J. A., Taylor, J., Todd, S., Tully, C., Cuevas, L. E. & Adams, E. R., 31/03/2022, In: Journal of Infection. 84, 3, p. 355-360 6 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review