Practical progress towards the development of recombinant antivenoms for snakebite envenoming

Menzies, S., Patel, R. N. & Ainsworth, S., 3/06/2025, In: Expert Opinion on Drug Discovery. 20, 6, p. 799-819 21 p.

Research output: Contribution to Journal/Magazine › Review article › peer-review

Dual Proteomics Strategies to Dissect and Quantify the Components of Nine Medically Important African Snake Venoms

Redureau, D., Amorim, F. G., Crasset, T., Berger, I., Schaffitzel, C., Menzies, S. K., Casewell, N. R. & Quinton, L., 13/05/2025, In: Toxins. 17, 5, 243.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

De novo designed proteins neutralize lethal snake venom toxins

Vázquez Torres, S., Benard Valle, M., Mackessy, S. P., Menzies, S. K., Casewell, N. R., Ahmadi, S., Burlet, N. J., Muratspahić, E., Sappington, I., Overath, M. D., Rivera-de-Torre, E., Ledergerber, J., Laustsen, A. H., Boddum, K., Bera, A. K., Kang, A., Brackenbrough, E., Cardoso, I. A., Crittenden, E. P. & Edge, R. J. & 12 others, Decarreau, J., Ragotte, R. J., Pillai, A. S., Abedi, M., Han, H. L., Gerben, S. R., Murray, A., Skotheim, R., Stuart, L., Stewart, L., Fryer, T. J. A. & Jenkins, T. P., 6/03/2025, In: Nature. 639, p. 225-231 7 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

African polyvalent antivenom can maintain pharmacological stability and ability to neutralise murine venom lethality for decades post-expiry: Evidence for increasing antivenom shelf life to aid in alleviating chronic shortages

Solano, G., Cunningham, S., Edge, R. J., Duran, G., Sanchez, A., Villalta, M., Clare, R. H., Wilkinson, M. C., Marriott, A. E., Abada, C., Menzies, S. K., Keen, M., Lalloo, D. G., Stienstra, Y., Abouyannis, M., Casewell, N. R., León, G. & Ainsworth, S., 13/03/2024, (E-pub ahead of print) In: BMJ Global Health. 9, 3, e014813.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins

Khalek, I. S., Laxme, R. R. S., Nguyen, Y. T. K., Khochare, S., Patel, R. N., Woehl, J., Smith, J. M., Saye-Francisco, K., Kim, Y., Mindrebo, L. M., Tran, Q., Kędzior, M., Boré, E., Limbo, O., Verma, M., Stanfield, R. L., Menzies, S. K., Ainsworth, S., Harrison, R. A. & Burton, D. R. & 5 others, Sok, D., Wilson, I. A., Casewell, N. R., Sunagar, K. & Jardine, J. G., 21/02/2024, In: Science Translational Medicine. 16, 735, eadk1867.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

ADDovenom: Thermostable Protein-Based ADDomer Nanoparticles as New Therapeutics for Snakebite Envenoming

Menzies, S. K., Arinto-Garcia, R., Amorim, F. G., Cardoso, I. A., Abada, C., Crasset, T., Durbesson, F., Edge, R. J., El-Kazzi, P., Hall, S., Redureau, D., Stenner, R., Boldrini-França, J., Sun, H., Roldão, A., Alves, P. M., Harrison, R. A., Vincentelli, R., Berger, I. & Quinton, L. & 2 others, Casewell, N. R. & Schaffitzel, C., 28/11/2023, In: Toxins. 15, 12, 673.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Next-Generation Sequencing for Venomics: Application of Multi-Enzymatic Limited Digestion for Inventorying the Snake Venom Arsenal

Amorim, F. G., Redureau, D., Crasset, T., Freuville, L., Baiwir, D., Mazzucchelli, G., Menzies, S. K., Casewell, N. R. & Quinton, L., 25/06/2023, In: Toxins. 15, 6, 357.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Two snakebite antivenoms have potential to reduce Eswatini's dependency upon a single, increasingly unavailable product: Results of preclinical efficacy testing

Menzies, S. K., Litschka-Koen, T., Edge, R. J., Alsolaiss, J., Crittenden, E., Hall, S. R., Westhorpe, A., Thomas, B., Murray, J., Shongwe, N., Padidar, S., Lalloo, D. G., Casewell, N. R., Pons, J. & Harrison, R. A., 15/09/2022, In: PLoS Neglected Tropical Diseases. 16, 9, e0010496.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Virus-like particles displaying conserved toxin epitopes stimulate polyspecific, murine antibody responses capable of snake venom recognition

Menzies, S. K., Dawson, C. A., Crittenden, E., Edge, R. J., Hall, S. R., Alsolaiss, J., Wilkinson, M. C., Casewell, N. R., Harrison, R. A. & Ainsworth, S., 5/07/2022, In: Scientific Reports. 12, 1, p. 11328

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Exploring the Utility of Recombinant Snake Venom Serine Protease Toxins as Immunogens for Generating Experimental Snakebite Antivenoms

Alomran, N., Blundell, P., Alsolaiss, J., Crittenden, E., Ainsworth, S., Dawson, C. A., Edge, R. J., Hall, S. R., Harrison, R. A., Wilkinson, M. C., Menzies, S. K. & Casewell, N. R., 29/06/2022, In: Toxins. 14, 7, 443.

Research output: Contribution to Journal/Magazine › Journal article › peer-review