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3D printing hybrid organometallic polymer-based biomaterials via laser two-photon polymerization

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3D printing hybrid organometallic polymer-based biomaterials via laser two-photon polymerization. / Balčiūnas, E.; Baldock, S.J.; Dreižė, N.; Grubliauskaitė, M.; Coultas, S.; Rochester, D.L.; Valius, M.; Hardy, J.G.; Baltriukienė, D.

In: Polymer International, Vol. 68, No. 11, 01.11.2019, p. 1928-1940.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Balčiūnas, E, Baldock, SJ, Dreižė, N, Grubliauskaitė, M, Coultas, S, Rochester, DL, Valius, M, Hardy, JG & Baltriukienė, D 2019, '3D printing hybrid organometallic polymer-based biomaterials via laser two-photon polymerization', Polymer International, vol. 68, no. 11, pp. 1928-1940. https://doi.org/10.1002/pi.5909

APA

Balčiūnas, E., Baldock, S. J., Dreižė, N., Grubliauskaitė, M., Coultas, S., Rochester, D. L., Valius, M., Hardy, J. G., & Baltriukienė, D. (2019). 3D printing hybrid organometallic polymer-based biomaterials via laser two-photon polymerization. Polymer International, 68(11), 1928-1940. https://doi.org/10.1002/pi.5909

Vancouver

Balčiūnas E, Baldock SJ, Dreižė N, Grubliauskaitė M, Coultas S, Rochester DL et al. 3D printing hybrid organometallic polymer-based biomaterials via laser two-photon polymerization. Polymer International. 2019 Nov 1;68(11):1928-1940. https://doi.org/10.1002/pi.5909

Author

Balčiūnas, E. ; Baldock, S.J. ; Dreižė, N. ; Grubliauskaitė, M. ; Coultas, S. ; Rochester, D.L. ; Valius, M. ; Hardy, J.G. ; Baltriukienė, D. / 3D printing hybrid organometallic polymer-based biomaterials via laser two-photon polymerization. In: Polymer International. 2019 ; Vol. 68, No. 11. pp. 1928-1940.

Bibtex

@article{daaa7850d4754c7eb42f7593db1e11a7,
title = "3D printing hybrid organometallic polymer-based biomaterials via laser two-photon polymerization",
abstract = "Materials with microscale structures are gaining increasing interest due to their range of technical and medical applications. Additive manufacturing approaches to such objects via laser two-photon polymerization, also known as multiphoton fabrication, enable the creation of new materials with diverse and tunable properties. Here, we investigate the properties of 3D structures composed of organometallic polymers incorporating aluminium, titanium, vanadium and zirconium. The organometallic polymer-based materials were analysed using a variety of techniques including SEM, energy-dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy analysis and contact angle measurements and their biocompatibility was tested in vitro. Cell viability and mode of death were determined by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and acridine orange/ethidium bromide staining. Polymers incorporating Al, Ti and Zr supported cell adhesion and proliferation, and showed low toxicity in vitro, whereas the organometallic polymer incorporating V was shown to be cytotoxic. Inductively coupled plasma optical emission spectrometry suggested that leaching of the V from the organometallic polymer is the likely cause of this. The preparation of the organometallic polymers is straightforward and both simple 2D and complex 3D structures can be fabricated with ease. Resolution tests of the newly developed organometallic polymer incorporating Al show that suspended lines with widths down to 200 nm can be fabricated. We believe that the materials described in this work show promising properties for the development of objects with sub-micron features for biomedical applications (e.g. biosensors, drug delivery devices, tissue scaffolds etc.). {\textcopyright} 2019 The Authors. Polymer International published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry. {\textcopyright} 2019 The Authors. Polymer International published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.",
keywords = "3D printing, laser two-photon polymerization, organometallic polymers, photopolymers, tissue engineering, Biocompatibility, Cell adhesion, Chemical industry, Contact angle, Drug delivery, Energy dispersive spectroscopy, Inductively coupled plasma, Medical applications, Optical emission spectroscopy, Organometallics, Photons, Photopolymers, Polymerization, Scaffolds (biology), Spectrometry, Tissue, Tissue engineering, X ray photoelectron spectroscopy, 3-D printing, Biomedical applications, Drug delivery devices, Inductively coupled plasma-optical emission spectrometry, Micro-scale structures, Organometallic polymer, Tunable properties, Two photon polymerization, 3D printers",
author = "E. Bal{\v c}iūnas and S.J. Baldock and N. Drei{\v z}ė and M. Grubliauskaitė and S. Coultas and D.L. Rochester and M. Valius and J.G. Hardy and D. Baltriukienė",
year = "2019",
month = nov,
day = "1",
doi = "10.1002/pi.5909",
language = "English",
volume = "68",
pages = "1928--1940",
journal = "Polymer International",
issn = "0959-8103",
publisher = "Wiley",
number = "11",

}

RIS

TY - JOUR

T1 - 3D printing hybrid organometallic polymer-based biomaterials via laser two-photon polymerization

AU - Balčiūnas, E.

AU - Baldock, S.J.

AU - Dreižė, N.

AU - Grubliauskaitė, M.

AU - Coultas, S.

AU - Rochester, D.L.

AU - Valius, M.

AU - Hardy, J.G.

AU - Baltriukienė, D.

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Materials with microscale structures are gaining increasing interest due to their range of technical and medical applications. Additive manufacturing approaches to such objects via laser two-photon polymerization, also known as multiphoton fabrication, enable the creation of new materials with diverse and tunable properties. Here, we investigate the properties of 3D structures composed of organometallic polymers incorporating aluminium, titanium, vanadium and zirconium. The organometallic polymer-based materials were analysed using a variety of techniques including SEM, energy-dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy analysis and contact angle measurements and their biocompatibility was tested in vitro. Cell viability and mode of death were determined by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and acridine orange/ethidium bromide staining. Polymers incorporating Al, Ti and Zr supported cell adhesion and proliferation, and showed low toxicity in vitro, whereas the organometallic polymer incorporating V was shown to be cytotoxic. Inductively coupled plasma optical emission spectrometry suggested that leaching of the V from the organometallic polymer is the likely cause of this. The preparation of the organometallic polymers is straightforward and both simple 2D and complex 3D structures can be fabricated with ease. Resolution tests of the newly developed organometallic polymer incorporating Al show that suspended lines with widths down to 200 nm can be fabricated. We believe that the materials described in this work show promising properties for the development of objects with sub-micron features for biomedical applications (e.g. biosensors, drug delivery devices, tissue scaffolds etc.). © 2019 The Authors. Polymer International published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry. © 2019 The Authors. Polymer International published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

AB - Materials with microscale structures are gaining increasing interest due to their range of technical and medical applications. Additive manufacturing approaches to such objects via laser two-photon polymerization, also known as multiphoton fabrication, enable the creation of new materials with diverse and tunable properties. Here, we investigate the properties of 3D structures composed of organometallic polymers incorporating aluminium, titanium, vanadium and zirconium. The organometallic polymer-based materials were analysed using a variety of techniques including SEM, energy-dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy analysis and contact angle measurements and their biocompatibility was tested in vitro. Cell viability and mode of death were determined by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and acridine orange/ethidium bromide staining. Polymers incorporating Al, Ti and Zr supported cell adhesion and proliferation, and showed low toxicity in vitro, whereas the organometallic polymer incorporating V was shown to be cytotoxic. Inductively coupled plasma optical emission spectrometry suggested that leaching of the V from the organometallic polymer is the likely cause of this. The preparation of the organometallic polymers is straightforward and both simple 2D and complex 3D structures can be fabricated with ease. Resolution tests of the newly developed organometallic polymer incorporating Al show that suspended lines with widths down to 200 nm can be fabricated. We believe that the materials described in this work show promising properties for the development of objects with sub-micron features for biomedical applications (e.g. biosensors, drug delivery devices, tissue scaffolds etc.). © 2019 The Authors. Polymer International published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry. © 2019 The Authors. Polymer International published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

KW - 3D printing

KW - laser two-photon polymerization

KW - organometallic polymers

KW - photopolymers

KW - tissue engineering

KW - Biocompatibility

KW - Cell adhesion

KW - Chemical industry

KW - Contact angle

KW - Drug delivery

KW - Energy dispersive spectroscopy

KW - Inductively coupled plasma

KW - Medical applications

KW - Optical emission spectroscopy

KW - Organometallics

KW - Photons

KW - Photopolymers

KW - Polymerization

KW - Scaffolds (biology)

KW - Spectrometry

KW - Tissue

KW - Tissue engineering

KW - X ray photoelectron spectroscopy

KW - 3-D printing

KW - Biomedical applications

KW - Drug delivery devices

KW - Inductively coupled plasma-optical emission spectrometry

KW - Micro-scale structures

KW - Organometallic polymer

KW - Tunable properties

KW - Two photon polymerization

KW - 3D printers

U2 - 10.1002/pi.5909

DO - 10.1002/pi.5909

M3 - Journal article

VL - 68

SP - 1928

EP - 1940

JO - Polymer International

JF - Polymer International

SN - 0959-8103

IS - 11

ER -