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A bioresorbable peripheral nerve stimulator for electronic pain block

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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A bioresorbable peripheral nerve stimulator for electronic pain block. / Lee, Geumbee; Ray, Emily; Yoon, Hong Joon et al.
In: Science Advances, Vol. 8, No. 40, eabp9169, 05.10.2022.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Lee, G, Ray, E, Yoon, HJ, Genovese, S, Choi, YS, Lee, MK, Şahin, S, Yan, Y, Ahn, HY, Bandodkar, AJ, Kim, J, Park, M, Ryu, H, Kwak, SS, Jung, YH, Odabas, A, Khandpur, U, Ray, WZ, MacEwan, MR & Rogers, JA 2022, 'A bioresorbable peripheral nerve stimulator for electronic pain block', Science Advances, vol. 8, no. 40, eabp9169. https://doi.org/10.1126/sciadv.abp9169

APA

Lee, G., Ray, E., Yoon, H. J., Genovese, S., Choi, Y. S., Lee, M. K., Şahin, S., Yan, Y., Ahn, H. Y., Bandodkar, A. J., Kim, J., Park, M., Ryu, H., Kwak, S. S., Jung, Y. H., Odabas, A., Khandpur, U., Ray, W. Z., MacEwan, M. R., & Rogers, J. A. (2022). A bioresorbable peripheral nerve stimulator for electronic pain block. Science Advances, 8(40), Article eabp9169. https://doi.org/10.1126/sciadv.abp9169

Vancouver

Lee G, Ray E, Yoon HJ, Genovese S, Choi YS, Lee MK et al. A bioresorbable peripheral nerve stimulator for electronic pain block. Science Advances. 2022 Oct 5;8(40):eabp9169. doi: 10.1126/sciadv.abp9169

Author

Lee, Geumbee ; Ray, Emily ; Yoon, Hong Joon et al. / A bioresorbable peripheral nerve stimulator for electronic pain block. In: Science Advances. 2022 ; Vol. 8, No. 40.

Bibtex

@article{ef1db0d7e93c4762b59785783dd4e0d9,
title = "A bioresorbable peripheral nerve stimulator for electronic pain block",
abstract = "Local electrical stimulation of peripheral nerves can block the propagation of action potentials, as an attractive alternative to pharmacological agents for the treatment of acute pain. Traditional hardware for such purposes, however, involves interfaces that can damage nerve tissue and, when used for temporary pain relief, that impose costs and risks due to requirements for surgical extraction after a period of need. Here, we introduce a bioresorbable nerve stimulator that enables electrical nerve block and associated pain mitigation without these drawbacks. This platform combines a collection of bioresorbable materials in architectures that support stable blocking with minimal adverse mechanical, electrical, or biochemical effects. Optimized designs ensure that the device disappears harmlessly in the body after a desired period of use. Studies in live animal models illustrate capabilities for complete nerve block and other key features of the technology. In certain clinically relevant scenarios, such approaches may reduce or eliminate the need for use of highly addictive drugs such as opioids.",
author = "Geumbee Lee and Emily Ray and Yoon, {Hong Joon} and Sabrina Genovese and Choi, {Yeon Sik} and Lee, {Min Kyu} and Samet {\c S}ahin and Ying Yan and Ahn, {Hak Young} and Bandodkar, {Amay J.} and Joohee Kim and Minsu Park and Hanjun Ryu and Kwak, {Sung Soo} and Jung, {Yei Hwan} and Arman Odabas and Umang Khandpur and Ray, {Wilson Z.} and MacEwan, {Matthew R.} and Rogers, {John A.}",
year = "2022",
month = oct,
day = "5",
doi = "10.1126/sciadv.abp9169",
language = "English",
volume = "8",
journal = "Science Advances",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "40",

}

RIS

TY - JOUR

T1 - A bioresorbable peripheral nerve stimulator for electronic pain block

AU - Lee, Geumbee

AU - Ray, Emily

AU - Yoon, Hong Joon

AU - Genovese, Sabrina

AU - Choi, Yeon Sik

AU - Lee, Min Kyu

AU - Şahin, Samet

AU - Yan, Ying

AU - Ahn, Hak Young

AU - Bandodkar, Amay J.

AU - Kim, Joohee

AU - Park, Minsu

AU - Ryu, Hanjun

AU - Kwak, Sung Soo

AU - Jung, Yei Hwan

AU - Odabas, Arman

AU - Khandpur, Umang

AU - Ray, Wilson Z.

AU - MacEwan, Matthew R.

AU - Rogers, John A.

PY - 2022/10/5

Y1 - 2022/10/5

N2 - Local electrical stimulation of peripheral nerves can block the propagation of action potentials, as an attractive alternative to pharmacological agents for the treatment of acute pain. Traditional hardware for such purposes, however, involves interfaces that can damage nerve tissue and, when used for temporary pain relief, that impose costs and risks due to requirements for surgical extraction after a period of need. Here, we introduce a bioresorbable nerve stimulator that enables electrical nerve block and associated pain mitigation without these drawbacks. This platform combines a collection of bioresorbable materials in architectures that support stable blocking with minimal adverse mechanical, electrical, or biochemical effects. Optimized designs ensure that the device disappears harmlessly in the body after a desired period of use. Studies in live animal models illustrate capabilities for complete nerve block and other key features of the technology. In certain clinically relevant scenarios, such approaches may reduce or eliminate the need for use of highly addictive drugs such as opioids.

AB - Local electrical stimulation of peripheral nerves can block the propagation of action potentials, as an attractive alternative to pharmacological agents for the treatment of acute pain. Traditional hardware for such purposes, however, involves interfaces that can damage nerve tissue and, when used for temporary pain relief, that impose costs and risks due to requirements for surgical extraction after a period of need. Here, we introduce a bioresorbable nerve stimulator that enables electrical nerve block and associated pain mitigation without these drawbacks. This platform combines a collection of bioresorbable materials in architectures that support stable blocking with minimal adverse mechanical, electrical, or biochemical effects. Optimized designs ensure that the device disappears harmlessly in the body after a desired period of use. Studies in live animal models illustrate capabilities for complete nerve block and other key features of the technology. In certain clinically relevant scenarios, such approaches may reduce or eliminate the need for use of highly addictive drugs such as opioids.

U2 - 10.1126/sciadv.abp9169

DO - 10.1126/sciadv.abp9169

M3 - Journal article

C2 - 36197971

AN - SCOPUS:85139352627

VL - 8

JO - Science Advances

JF - Science Advances

SN - 2375-2548

IS - 40

M1 - eabp9169

ER -