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A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy

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A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy. / Brookes, Keeley-Joanne; Mill, Jon; Guindalini, Camilla et al.

In: Archives of General Psychiatry, Vol. 63, No. 1, 01.2006, p. 74-81.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Brookes, K-J, Mill, J, Guindalini, C, Curran, S, Xu, X, Knight, J, Chen, C-K, Huang, Y-S, Sethna, V, Taylor, E, Chen, W, Breen, G & Asherson, P 2006, 'A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy', Archives of General Psychiatry, vol. 63, no. 1, pp. 74-81. https://doi.org/10.1001/archpsyc.63.1.74

APA

Brookes, K-J., Mill, J., Guindalini, C., Curran, S., Xu, X., Knight, J., Chen, C-K., Huang, Y-S., Sethna, V., Taylor, E., Chen, W., Breen, G., & Asherson, P. (2006). A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy. Archives of General Psychiatry, 63(1), 74-81. https://doi.org/10.1001/archpsyc.63.1.74

Vancouver

Brookes K-J, Mill J, Guindalini C, Curran S, Xu X, Knight J et al. A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy. Archives of General Psychiatry. 2006 Jan;63(1):74-81. doi: 10.1001/archpsyc.63.1.74

Author

Brookes, Keeley-Joanne ; Mill, Jon ; Guindalini, Camilla et al. / A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy. In: Archives of General Psychiatry. 2006 ; Vol. 63, No. 1. pp. 74-81.

Bibtex

@article{4b7d2062e6e4412bbcdf0acf5cd11bca,
title = "A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy",
abstract = "CONTEXT: Attention-deficit/hyperactivity disorder (ADHD) is a common heritable childhood behavioral disorder. Identifying risk factors for ADHD may lead to improved intervention and prevention. The dopamine transporter gene (DAT1) is associated with ADHD in several studies, with an average 1.2 odds ratio and evidence of heterogeneity across data sets.OBJECTIVE: To investigate sources of heterogeneity by refining the DAT1 association using additional markers and investigating gene-environment interaction between DAT1 and maternal use of alcohol and tobacco during pregnancy.DESIGN: Prospective study.SETTING AND PATIENTS: Children with ADHD from child behavior clinics in the southeast of England and in the Taipei area of Taiwan.INTERVENTIONS: Within-family tests of association using 2 repeat polymorphisms in the 3' untranslated region and intron 8 plus additional markers in the English sample.MAIN OUTCOME MEASURES: Transmission ratios of risk alleles from heterozygote parents to affected offspring and comparison of the transmission ratios in high- and low-exposure groups for the environmental variables.RESULTS: A novel association was identified between ADHD, the intron 8 polymorphism, and a specific risk haplotype in both English and Taiwanese samples. The risk haplotype showed significant interactions with maternal use of alcohol during pregnancy.CONCLUSIONS: The identification of a common haplotype in 2 independent populations is an important step toward identifying functionally significant regions of DAT1. Interaction between DAT1 genotypes and maternal use of alcohol during pregnancy suggests that DAT1 moderates the environmental risk and has implications for the prevention of ADHD. Further studies are required to delineate the precise causal risk factor involved in this interaction.",
keywords = "Alcohol Drinking, Asian Continental Ancestry Group, Attention Deficit Disorder with Hyperactivity, Chromosome Mapping, Dopamine Plasma Membrane Transport Proteins, England, Ethanol, European Continental Ancestry Group, Female, Genetic Markers, Genetic Predisposition to Disease, Haplotypes, Humans, Linkage Disequilibrium, Maternal Exposure, Maternal-Fetal Exchange, Pregnancy, Pregnancy Complications, Prospective Studies, Risk Factors, Smoking, Taiwan",
author = "Keeley-Joanne Brookes and Jon Mill and Camilla Guindalini and Sarah Curran and Xiaohui Xu and Jo Knight and Chih-Ken Chen and Yu-Shu Huang and Vaheshta Sethna and Eric Taylor and Wai Chen and Gerome Breen and Philip Asherson",
year = "2006",
month = jan,
doi = "10.1001/archpsyc.63.1.74",
language = "English",
volume = "63",
pages = "74--81",
journal = "Archives of General Psychiatry",
issn = "0003-990X",
publisher = "American Medical Association",
number = "1",

}

RIS

TY - JOUR

T1 - A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy

AU - Brookes, Keeley-Joanne

AU - Mill, Jon

AU - Guindalini, Camilla

AU - Curran, Sarah

AU - Xu, Xiaohui

AU - Knight, Jo

AU - Chen, Chih-Ken

AU - Huang, Yu-Shu

AU - Sethna, Vaheshta

AU - Taylor, Eric

AU - Chen, Wai

AU - Breen, Gerome

AU - Asherson, Philip

PY - 2006/1

Y1 - 2006/1

N2 - CONTEXT: Attention-deficit/hyperactivity disorder (ADHD) is a common heritable childhood behavioral disorder. Identifying risk factors for ADHD may lead to improved intervention and prevention. The dopamine transporter gene (DAT1) is associated with ADHD in several studies, with an average 1.2 odds ratio and evidence of heterogeneity across data sets.OBJECTIVE: To investigate sources of heterogeneity by refining the DAT1 association using additional markers and investigating gene-environment interaction between DAT1 and maternal use of alcohol and tobacco during pregnancy.DESIGN: Prospective study.SETTING AND PATIENTS: Children with ADHD from child behavior clinics in the southeast of England and in the Taipei area of Taiwan.INTERVENTIONS: Within-family tests of association using 2 repeat polymorphisms in the 3' untranslated region and intron 8 plus additional markers in the English sample.MAIN OUTCOME MEASURES: Transmission ratios of risk alleles from heterozygote parents to affected offspring and comparison of the transmission ratios in high- and low-exposure groups for the environmental variables.RESULTS: A novel association was identified between ADHD, the intron 8 polymorphism, and a specific risk haplotype in both English and Taiwanese samples. The risk haplotype showed significant interactions with maternal use of alcohol during pregnancy.CONCLUSIONS: The identification of a common haplotype in 2 independent populations is an important step toward identifying functionally significant regions of DAT1. Interaction between DAT1 genotypes and maternal use of alcohol during pregnancy suggests that DAT1 moderates the environmental risk and has implications for the prevention of ADHD. Further studies are required to delineate the precise causal risk factor involved in this interaction.

AB - CONTEXT: Attention-deficit/hyperactivity disorder (ADHD) is a common heritable childhood behavioral disorder. Identifying risk factors for ADHD may lead to improved intervention and prevention. The dopamine transporter gene (DAT1) is associated with ADHD in several studies, with an average 1.2 odds ratio and evidence of heterogeneity across data sets.OBJECTIVE: To investigate sources of heterogeneity by refining the DAT1 association using additional markers and investigating gene-environment interaction between DAT1 and maternal use of alcohol and tobacco during pregnancy.DESIGN: Prospective study.SETTING AND PATIENTS: Children with ADHD from child behavior clinics in the southeast of England and in the Taipei area of Taiwan.INTERVENTIONS: Within-family tests of association using 2 repeat polymorphisms in the 3' untranslated region and intron 8 plus additional markers in the English sample.MAIN OUTCOME MEASURES: Transmission ratios of risk alleles from heterozygote parents to affected offspring and comparison of the transmission ratios in high- and low-exposure groups for the environmental variables.RESULTS: A novel association was identified between ADHD, the intron 8 polymorphism, and a specific risk haplotype in both English and Taiwanese samples. The risk haplotype showed significant interactions with maternal use of alcohol during pregnancy.CONCLUSIONS: The identification of a common haplotype in 2 independent populations is an important step toward identifying functionally significant regions of DAT1. Interaction between DAT1 genotypes and maternal use of alcohol during pregnancy suggests that DAT1 moderates the environmental risk and has implications for the prevention of ADHD. Further studies are required to delineate the precise causal risk factor involved in this interaction.

KW - Alcohol Drinking

KW - Asian Continental Ancestry Group

KW - Attention Deficit Disorder with Hyperactivity

KW - Chromosome Mapping

KW - Dopamine Plasma Membrane Transport Proteins

KW - England

KW - Ethanol

KW - European Continental Ancestry Group

KW - Female

KW - Genetic Markers

KW - Genetic Predisposition to Disease

KW - Haplotypes

KW - Humans

KW - Linkage Disequilibrium

KW - Maternal Exposure

KW - Maternal-Fetal Exchange

KW - Pregnancy

KW - Pregnancy Complications

KW - Prospective Studies

KW - Risk Factors

KW - Smoking

KW - Taiwan

U2 - 10.1001/archpsyc.63.1.74

DO - 10.1001/archpsyc.63.1.74

M3 - Journal article

C2 - 16389200

VL - 63

SP - 74

EP - 81

JO - Archives of General Psychiatry

JF - Archives of General Psychiatry

SN - 0003-990X

IS - 1

ER -