Home > Research > Publications & Outputs > A decade of sustained selection pressure on two...

Research

Associated organisational units

Links

Text available via DOI:

Keywords

View graph of relations

A decade of sustained selection pressure on two surface sites of the VP1 protein of Enterovirus A71 suggests that immune evasion may be an indirect driver for virulence

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

A decade of sustained selection pressure on two surface sites of the VP1 protein of Enterovirus A71 suggests that immune evasion may be an indirect driver for virulence. / Roberts, Ryan; Yee, Pinn Tsin Isabel; Mujawar, Shama et al.
In: Scientific Reports, Vol. 9, No. 1, 5427, 01.04.2019.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Roberts, R, Yee, PTI, Mujawar, S, Lahiri, C, Poh, CL & Gatherer, D 2019, 'A decade of sustained selection pressure on two surface sites of the VP1 protein of Enterovirus A71 suggests that immune evasion may be an indirect driver for virulence', Scientific Reports, vol. 9, no. 1, 5427. https://doi.org/10.1038/s41598-019-41662-8

APA

Roberts, R., Yee, P. T. I., Mujawar, S., Lahiri, C., Poh, C. L., & Gatherer, D. (2019). A decade of sustained selection pressure on two surface sites of the VP1 protein of Enterovirus A71 suggests that immune evasion may be an indirect driver for virulence. Scientific Reports, 9(1), Article 5427. https://doi.org/10.1038/s41598-019-41662-8

Vancouver

Roberts R, Yee PTI, Mujawar S, Lahiri C, Poh CL, Gatherer D. A decade of sustained selection pressure on two surface sites of the VP1 protein of Enterovirus A71 suggests that immune evasion may be an indirect driver for virulence. Scientific Reports. 2019 Apr 1;9(1):5427. doi: 10.1038/s41598-019-41662-8

Author

Roberts, Ryan ; Yee, Pinn Tsin Isabel ; Mujawar, Shama et al. / A decade of sustained selection pressure on two surface sites of the VP1 protein of Enterovirus A71 suggests that immune evasion may be an indirect driver for virulence. In: Scientific Reports. 2019 ; Vol. 9, No. 1.

Bibtex

@article{3c080c5813a94b90803268f4246d8d8f,
title = "A decade of sustained selection pressure on two surface sites of the VP1 protein of Enterovirus A71 suggests that immune evasion may be an indirect driver for virulence",
abstract = "Enterovirus A71 (EV-A71) is an emerging pathogen in the Enterovirus A species group. EV-A71 causes hand, foot and mouth disease (HFMD), with virulent variants exhibiting polio-like acute flaccid paralysis and other central nervous system manifestations. We analysed all enterovirus A71 complete genomes with collection dates from 2008 to mid-2018. All sub-genotypes exhibit a strong molecular clock with omega (dN/dS) suggesting strong purifying selection. In sub-genotypes B5 and C4, positive selection can be detected at two surface sites on the VP1 protein, also detected in positive selection studies performed prior to 2008. Toggling of a limited repertoire of amino acids at these positively selected residues over the last decade suggests that EV-A71 may be undergoing a sustained frequency-dependent selection process for immune evasion, raising issues for vaccine development. These same sites have also been previously implicated in virus-host binding and strain-associated severity of HFMD, suggesting that immune evasion may be an indirect driver for virulence (154 words).",
keywords = "EV71, enterovirus, enterovirus A-71",
author = "Ryan Roberts and Yee, {Pinn Tsin Isabel} and Shama Mujawar and Chandrajit Lahiri and Poh, {Chit Laa} and Derek Gatherer",
year = "2019",
month = apr,
day = "1",
doi = "10.1038/s41598-019-41662-8",
language = "English",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - A decade of sustained selection pressure on two surface sites of the VP1 protein of Enterovirus A71 suggests that immune evasion may be an indirect driver for virulence

AU - Roberts, Ryan

AU - Yee, Pinn Tsin Isabel

AU - Mujawar, Shama

AU - Lahiri, Chandrajit

AU - Poh, Chit Laa

AU - Gatherer, Derek

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Enterovirus A71 (EV-A71) is an emerging pathogen in the Enterovirus A species group. EV-A71 causes hand, foot and mouth disease (HFMD), with virulent variants exhibiting polio-like acute flaccid paralysis and other central nervous system manifestations. We analysed all enterovirus A71 complete genomes with collection dates from 2008 to mid-2018. All sub-genotypes exhibit a strong molecular clock with omega (dN/dS) suggesting strong purifying selection. In sub-genotypes B5 and C4, positive selection can be detected at two surface sites on the VP1 protein, also detected in positive selection studies performed prior to 2008. Toggling of a limited repertoire of amino acids at these positively selected residues over the last decade suggests that EV-A71 may be undergoing a sustained frequency-dependent selection process for immune evasion, raising issues for vaccine development. These same sites have also been previously implicated in virus-host binding and strain-associated severity of HFMD, suggesting that immune evasion may be an indirect driver for virulence (154 words).

AB - Enterovirus A71 (EV-A71) is an emerging pathogen in the Enterovirus A species group. EV-A71 causes hand, foot and mouth disease (HFMD), with virulent variants exhibiting polio-like acute flaccid paralysis and other central nervous system manifestations. We analysed all enterovirus A71 complete genomes with collection dates from 2008 to mid-2018. All sub-genotypes exhibit a strong molecular clock with omega (dN/dS) suggesting strong purifying selection. In sub-genotypes B5 and C4, positive selection can be detected at two surface sites on the VP1 protein, also detected in positive selection studies performed prior to 2008. Toggling of a limited repertoire of amino acids at these positively selected residues over the last decade suggests that EV-A71 may be undergoing a sustained frequency-dependent selection process for immune evasion, raising issues for vaccine development. These same sites have also been previously implicated in virus-host binding and strain-associated severity of HFMD, suggesting that immune evasion may be an indirect driver for virulence (154 words).

KW - EV71

KW - enterovirus

KW - enterovirus A-71

U2 - 10.1038/s41598-019-41662-8

DO - 10.1038/s41598-019-41662-8

M3 - Journal article

C2 - 30931960

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 5427

ER -