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Harvard
Strange, A, Capon, F, Spencer, CCA
, Knight, J, Weale, ME, Allen, MH, Barton, A, Band, G, Bellenguez, C, Bergboer, JGM, Blackwell, JM, Bramon, E, Bumpstead, SJ, Casas, JP, Cork, MJ, Corvin, A, Deloukas, P, Dilthey, A, Duncanson, A, Edkins, S, Estivill, X, Fitzgerald, O, Freeman, C, Giardina, E, Gray, E, Hofer, A, Hüffmeier, U, Hunt, SE, Irvine, AD, Jankowski, J, Kirby, B, Langford, C, Lascorz, J, Leman, J, Leslie, S, Mallbris, L, Markus, HS, Mathew, CG, McLean, WHI, McManus, R, Mössner, R, Moutsianas, L, Naluai, AT, Nestle, FO, Novelli, G, Onoufriadis, A, Palmer, CNA, Perricone, C, Pirinen, M, Plomin, R & Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2 2010, '
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1',
Nature Genetics, vol. 42, no. 11, pp. 985-990.
https://doi.org/10.1038/ng.694APA
Strange, A., Capon, F., Spencer, C. C. A.
, Knight, J., Weale, M. E., Allen, M. H., Barton, A., Band, G., Bellenguez, C., Bergboer, J. G. M., Blackwell, J. M., Bramon, E., Bumpstead, S. J., Casas, J. P., Cork, M. J., Corvin, A., Deloukas, P., Dilthey, A., Duncanson, A., ... Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2 (2010).
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
Nature Genetics,
42(11), 985-990.
https://doi.org/10.1038/ng.694Vancouver
Author
Bibtex
@article{76210fa972b84e629f8bf8b296bda4ef,
title = "A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1",
abstract = "To identify new susceptibility loci for psoriasis, we undertook a genome-wide association study of 594,224 SNPs in 2,622 individuals with psoriasis and 5,667 controls. We identified associations at eight previously unreported genomic loci. Seven loci harbored genes with recognized immune functions (IL28RA, REL, IFIH1, ERAP1, TRAF3IP2, NFKBIA and TYK2). These associations were replicated in 9,079 European samples (six loci with a combined P < 5 × 10⁻⁸ and two loci with a combined P < 5 × 10⁻⁷). We also report compelling evidence for an interaction between the HLA-C and ERAP1 loci (combined P = 6.95 × 10⁻⁶). ERAP1 plays an important role in MHC class I peptide processing. ERAP1 variants only influenced psoriasis susceptibility in individuals carrying the HLA-C risk allele. Our findings implicate pathways that integrate epidermal barrier dysfunction with innate and adaptive immune dysregulation in psoriasis pathogenesis.",
keywords = "Aminopeptidases, Chromosome Mapping, Chromosomes, Human, Chromosomes, Human, X, Europe, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, HLA-C Antigens, Humans, Major Histocompatibility Complex, Polymorphism, Single Nucleotide, Psoriasis, Reference Values, Risk Assessment",
author = "Amy Strange and Francesca Capon and Spencer, {Chris C. A.} and Jo Knight and Weale, {Michael E.} and Allen, {Michael H.} and Anne Barton and Gavin Band and C{\'e}line Bellenguez and Bergboer, {Judith G M} and Blackwell, {Jenefer M} and Elvira Bramon and Bumpstead, {Suzannah J} and Casas, {Juan P} and Cork, {Michael J} and Aiden Corvin and Panos Deloukas and Alexander Dilthey and Audrey Duncanson and Sarah Edkins and Xavier Estivill and Oliver Fitzgerald and Colin Freeman and Emiliano Giardina and Emma Gray and Angelika Hofer and Ulrike H{\"u}ffmeier and Hunt, {Sarah E} and Irvine, {Alan D} and Janusz Jankowski and Brian Kirby and Cordelia Langford and Jes{\'u}s Lascorz and Joyce Leman and Stephen Leslie and Lotus Mallbris and Markus, {Hugh S} and Mathew, {Christopher G} and McLean, {W H Irwin} and Ross McManus and Rotraut M{\"o}ssner and Loukas Moutsianas and Naluai, {Asa T} and Nestle, {Frank O} and Giuseppe Novelli and Alexandros Onoufriadis and Palmer, {Colin N A} and Carlo Perricone and Matti Pirinen and Robert Plomin and {Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2}",
year = "2010",
month = nov,
doi = "10.1038/ng.694",
language = "English",
volume = "42",
pages = "985--990",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "11",
}
RIS
TY - JOUR
T1 - A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
AU - Strange, Amy
AU - Capon, Francesca
AU - Spencer, Chris C. A.
AU - Knight, Jo
AU - Weale, Michael E.
AU - Allen, Michael H.
AU - Barton, Anne
AU - Band, Gavin
AU - Bellenguez, Céline
AU - Bergboer, Judith G M
AU - Blackwell, Jenefer M
AU - Bramon, Elvira
AU - Bumpstead, Suzannah J
AU - Casas, Juan P
AU - Cork, Michael J
AU - Corvin, Aiden
AU - Deloukas, Panos
AU - Dilthey, Alexander
AU - Duncanson, Audrey
AU - Edkins, Sarah
AU - Estivill, Xavier
AU - Fitzgerald, Oliver
AU - Freeman, Colin
AU - Giardina, Emiliano
AU - Gray, Emma
AU - Hofer, Angelika
AU - Hüffmeier, Ulrike
AU - Hunt, Sarah E
AU - Irvine, Alan D
AU - Jankowski, Janusz
AU - Kirby, Brian
AU - Langford, Cordelia
AU - Lascorz, Jesús
AU - Leman, Joyce
AU - Leslie, Stephen
AU - Mallbris, Lotus
AU - Markus, Hugh S
AU - Mathew, Christopher G
AU - McLean, W H Irwin
AU - McManus, Ross
AU - Mössner, Rotraut
AU - Moutsianas, Loukas
AU - Naluai, Asa T
AU - Nestle, Frank O
AU - Novelli, Giuseppe
AU - Onoufriadis, Alexandros
AU - Palmer, Colin N A
AU - Perricone, Carlo
AU - Pirinen, Matti
AU - Plomin, Robert
AU - Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2
PY - 2010/11
Y1 - 2010/11
N2 - To identify new susceptibility loci for psoriasis, we undertook a genome-wide association study of 594,224 SNPs in 2,622 individuals with psoriasis and 5,667 controls. We identified associations at eight previously unreported genomic loci. Seven loci harbored genes with recognized immune functions (IL28RA, REL, IFIH1, ERAP1, TRAF3IP2, NFKBIA and TYK2). These associations were replicated in 9,079 European samples (six loci with a combined P < 5 × 10⁻⁸ and two loci with a combined P < 5 × 10⁻⁷). We also report compelling evidence for an interaction between the HLA-C and ERAP1 loci (combined P = 6.95 × 10⁻⁶). ERAP1 plays an important role in MHC class I peptide processing. ERAP1 variants only influenced psoriasis susceptibility in individuals carrying the HLA-C risk allele. Our findings implicate pathways that integrate epidermal barrier dysfunction with innate and adaptive immune dysregulation in psoriasis pathogenesis.
AB - To identify new susceptibility loci for psoriasis, we undertook a genome-wide association study of 594,224 SNPs in 2,622 individuals with psoriasis and 5,667 controls. We identified associations at eight previously unreported genomic loci. Seven loci harbored genes with recognized immune functions (IL28RA, REL, IFIH1, ERAP1, TRAF3IP2, NFKBIA and TYK2). These associations were replicated in 9,079 European samples (six loci with a combined P < 5 × 10⁻⁸ and two loci with a combined P < 5 × 10⁻⁷). We also report compelling evidence for an interaction between the HLA-C and ERAP1 loci (combined P = 6.95 × 10⁻⁶). ERAP1 plays an important role in MHC class I peptide processing. ERAP1 variants only influenced psoriasis susceptibility in individuals carrying the HLA-C risk allele. Our findings implicate pathways that integrate epidermal barrier dysfunction with innate and adaptive immune dysregulation in psoriasis pathogenesis.
KW - Aminopeptidases
KW - Chromosome Mapping
KW - Chromosomes, Human
KW - Chromosomes, Human, X
KW - Europe
KW - Genetic Predisposition to Disease
KW - Genetic Variation
KW - Genome-Wide Association Study
KW - HLA-C Antigens
KW - Humans
KW - Major Histocompatibility Complex
KW - Polymorphism, Single Nucleotide
KW - Psoriasis
KW - Reference Values
KW - Risk Assessment
U2 - 10.1038/ng.694
DO - 10.1038/ng.694
M3 - Letter
C2 - 20953190
VL - 42
SP - 985
EP - 990
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 11
ER -
