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A live attenuated-vaccine model confers cross-protective immunity against different species of the leptospira genus

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A live attenuated-vaccine model confers cross-protective immunity against different species of the leptospira genus. / Wunder, E.A.; Adhikarla, H.; Hamond, C.; Bonner, K.A.O.; Liang, L.; Rodrigues, C.B.; Bisht, V.; Nally, J.E.; Alt, D.P.; Reis, M.G.; Diggle, P.J.; Felgner, P.L.; Ko, A.

In: eLife, Vol. 10, 26.01.2021, p. 1-20.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Wunder, EA, Adhikarla, H, Hamond, C, Bonner, KAO, Liang, L, Rodrigues, CB, Bisht, V, Nally, JE, Alt, DP, Reis, MG, Diggle, PJ, Felgner, PL & Ko, A 2021, 'A live attenuated-vaccine model confers cross-protective immunity against different species of the leptospira genus', eLife, vol. 10, pp. 1-20. https://doi.org/10.7554/ELIFE.64166

APA

Wunder, E. A., Adhikarla, H., Hamond, C., Bonner, K. A. O., Liang, L., Rodrigues, C. B., Bisht, V., Nally, J. E., Alt, D. P., Reis, M. G., Diggle, P. J., Felgner, P. L., & Ko, A. (2021). A live attenuated-vaccine model confers cross-protective immunity against different species of the leptospira genus. eLife, 10, 1-20. https://doi.org/10.7554/ELIFE.64166

Vancouver

Wunder EA, Adhikarla H, Hamond C, Bonner KAO, Liang L, Rodrigues CB et al. A live attenuated-vaccine model confers cross-protective immunity against different species of the leptospira genus. eLife. 2021 Jan 26;10:1-20. https://doi.org/10.7554/ELIFE.64166

Author

Wunder, E.A. ; Adhikarla, H. ; Hamond, C. ; Bonner, K.A.O. ; Liang, L. ; Rodrigues, C.B. ; Bisht, V. ; Nally, J.E. ; Alt, D.P. ; Reis, M.G. ; Diggle, P.J. ; Felgner, P.L. ; Ko, A. / A live attenuated-vaccine model confers cross-protective immunity against different species of the leptospira genus. In: eLife. 2021 ; Vol. 10. pp. 1-20.

Bibtex

@article{8b2ad9ee72294476a68b0007c16d979b,
title = "A live attenuated-vaccine model confers cross-protective immunity against different species of the leptospira genus",
abstract = "Leptospirosis is the leading zoonotic disease in terms of morbidity and mortality worldwide. Effective prevention is urgently needed as the drivers of disease transmission continue to intensify. The key challenge has been developing a widely applicable vaccine that protects against the >300 serovars that can cause leptospirosis. Live attenuated mutants are enticing vaccine candidates and poorly explored in the field. We evaluated a recently characterized motility-deficient mutant lacking the expression of a flagellar protein, FcpA. Although the fcpA- mutant has lost its ability to cause disease, transient bacteremia was observed. In two animal models, immunization with a single dose of the fcpA- mutant was sufficient to induce a robust anti-protein antibodies response that promoted protection against infection with different pathogenic Leptospira species. Furthermore, characterization of the immune response identified a small repertoire of biologically relevant proteins that are highly conserved among pathogenic Leptospira species and potential correlates of cross-protective immunity. {\textcopyright} 2021, eLife Sciences Publications Ltd. All rights reserved.",
author = "E.A. Wunder and H. Adhikarla and C. Hamond and K.A.O. Bonner and L. Liang and C.B. Rodrigues and V. Bisht and J.E. Nally and D.P. Alt and M.G. Reis and P.J. Diggle and P.L. Felgner and A. Ko",
year = "2021",
month = jan,
day = "26",
doi = "10.7554/ELIFE.64166",
language = "English",
volume = "10",
pages = "1--20",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications Ltd",

}

RIS

TY - JOUR

T1 - A live attenuated-vaccine model confers cross-protective immunity against different species of the leptospira genus

AU - Wunder, E.A.

AU - Adhikarla, H.

AU - Hamond, C.

AU - Bonner, K.A.O.

AU - Liang, L.

AU - Rodrigues, C.B.

AU - Bisht, V.

AU - Nally, J.E.

AU - Alt, D.P.

AU - Reis, M.G.

AU - Diggle, P.J.

AU - Felgner, P.L.

AU - Ko, A.

PY - 2021/1/26

Y1 - 2021/1/26

N2 - Leptospirosis is the leading zoonotic disease in terms of morbidity and mortality worldwide. Effective prevention is urgently needed as the drivers of disease transmission continue to intensify. The key challenge has been developing a widely applicable vaccine that protects against the >300 serovars that can cause leptospirosis. Live attenuated mutants are enticing vaccine candidates and poorly explored in the field. We evaluated a recently characterized motility-deficient mutant lacking the expression of a flagellar protein, FcpA. Although the fcpA- mutant has lost its ability to cause disease, transient bacteremia was observed. In two animal models, immunization with a single dose of the fcpA- mutant was sufficient to induce a robust anti-protein antibodies response that promoted protection against infection with different pathogenic Leptospira species. Furthermore, characterization of the immune response identified a small repertoire of biologically relevant proteins that are highly conserved among pathogenic Leptospira species and potential correlates of cross-protective immunity. © 2021, eLife Sciences Publications Ltd. All rights reserved.

AB - Leptospirosis is the leading zoonotic disease in terms of morbidity and mortality worldwide. Effective prevention is urgently needed as the drivers of disease transmission continue to intensify. The key challenge has been developing a widely applicable vaccine that protects against the >300 serovars that can cause leptospirosis. Live attenuated mutants are enticing vaccine candidates and poorly explored in the field. We evaluated a recently characterized motility-deficient mutant lacking the expression of a flagellar protein, FcpA. Although the fcpA- mutant has lost its ability to cause disease, transient bacteremia was observed. In two animal models, immunization with a single dose of the fcpA- mutant was sufficient to induce a robust anti-protein antibodies response that promoted protection against infection with different pathogenic Leptospira species. Furthermore, characterization of the immune response identified a small repertoire of biologically relevant proteins that are highly conserved among pathogenic Leptospira species and potential correlates of cross-protective immunity. © 2021, eLife Sciences Publications Ltd. All rights reserved.

U2 - 10.7554/ELIFE.64166

DO - 10.7554/ELIFE.64166

M3 - Journal article

VL - 10

SP - 1

EP - 20

JO - eLife

JF - eLife

SN - 2050-084X

ER -