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A longitudinal modelling study estimates acute symptoms of community acquired pneumonia recover to baseline by 10 days

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A longitudinal modelling study estimates acute symptoms of community acquired pneumonia recover to baseline by 10 days. / Wootton, Daniel G.; Dickinson, Laura; Pertinez, Henry et al.
In: European Respiratory Journal, Vol. 49, No. 6, 1602170, 01.06.2017.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Wootton, DG, Dickinson, L, Pertinez, H, Court, J, Eneje, O, Keogan, L, Macfarlane, L, Wilks, S, Gallagher, J, Woodhead, M, Gordon, SB & Diggle, PJ 2017, 'A longitudinal modelling study estimates acute symptoms of community acquired pneumonia recover to baseline by 10 days', European Respiratory Journal, vol. 49, no. 6, 1602170. https://doi.org/10.1183/13993003.02170-2016

APA

Wootton, D. G., Dickinson, L., Pertinez, H., Court, J., Eneje, O., Keogan, L., Macfarlane, L., Wilks, S., Gallagher, J., Woodhead, M., Gordon, S. B., & Diggle, P. J. (2017). A longitudinal modelling study estimates acute symptoms of community acquired pneumonia recover to baseline by 10 days. European Respiratory Journal, 49(6), Article 1602170. https://doi.org/10.1183/13993003.02170-2016

Vancouver

Wootton DG, Dickinson L, Pertinez H, Court J, Eneje O, Keogan L et al. A longitudinal modelling study estimates acute symptoms of community acquired pneumonia recover to baseline by 10 days. European Respiratory Journal. 2017 Jun 1;49(6):1602170. doi: 10.1183/13993003.02170-2016

Author

Wootton, Daniel G. ; Dickinson, Laura ; Pertinez, Henry et al. / A longitudinal modelling study estimates acute symptoms of community acquired pneumonia recover to baseline by 10 days. In: European Respiratory Journal. 2017 ; Vol. 49, No. 6.

Bibtex

@article{e16db015f9a04c2a99df9db2720d83b5,
title = "A longitudinal modelling study estimates acute symptoms of community acquired pneumonia recover to baseline by 10 days",
abstract = "Our aims were to address three fundamental questions relating to the symptoms of community-acquired pneumonia (CAP): Do patients completely recover from pneumonia symptoms? How long does this recovery take? Which factors influence symptomatic recovery?We prospectively recruited patients at two hospitals in Liverpool, UK, into a longitudinal, observational cohort study and modelled symptom recovery from CAP. We excluded patients with cancer, immunosuppression or advanced dementia, and those who were intubated or palliated from admission. We derived a statistical model to describe symptom patterns.We recruited 169 (52% male) adults. Multivariable analysis demonstrated that the time taken to recover to baseline was determined by the initial severity of symptoms. Severity of symptoms was associated with comorbidity and was inversely related to age. The pattern of symptom recovery was exponential and most patients' symptoms returned to baseline by 10 days.These results will inform the advice given to patients regarding the resolution of their symptoms. The recovery model described here will facilitate the use of symptom recovery as an outcome measure in future clinical trials.",
author = "Wootton, {Daniel G.} and Laura Dickinson and Henry Pertinez and Joanne Court and Odiri Eneje and Lynne Keogan and Laura Macfarlane and Sarah Wilks and Jane Gallagher and Mark Woodhead and Gordon, {Stephen B.} and Diggle, {Peter J.}",
note = "Copyright {\textcopyright}ERS 2017.",
year = "2017",
month = jun,
day = "1",
doi = "10.1183/13993003.02170-2016",
language = "English",
volume = "49",
journal = "European Respiratory Journal",
issn = "0903-1936",
publisher = "European Respiratory Society",
number = "6",

}

RIS

TY - JOUR

T1 - A longitudinal modelling study estimates acute symptoms of community acquired pneumonia recover to baseline by 10 days

AU - Wootton, Daniel G.

AU - Dickinson, Laura

AU - Pertinez, Henry

AU - Court, Joanne

AU - Eneje, Odiri

AU - Keogan, Lynne

AU - Macfarlane, Laura

AU - Wilks, Sarah

AU - Gallagher, Jane

AU - Woodhead, Mark

AU - Gordon, Stephen B.

AU - Diggle, Peter J.

N1 - Copyright ©ERS 2017.

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Our aims were to address three fundamental questions relating to the symptoms of community-acquired pneumonia (CAP): Do patients completely recover from pneumonia symptoms? How long does this recovery take? Which factors influence symptomatic recovery?We prospectively recruited patients at two hospitals in Liverpool, UK, into a longitudinal, observational cohort study and modelled symptom recovery from CAP. We excluded patients with cancer, immunosuppression or advanced dementia, and those who were intubated or palliated from admission. We derived a statistical model to describe symptom patterns.We recruited 169 (52% male) adults. Multivariable analysis demonstrated that the time taken to recover to baseline was determined by the initial severity of symptoms. Severity of symptoms was associated with comorbidity and was inversely related to age. The pattern of symptom recovery was exponential and most patients' symptoms returned to baseline by 10 days.These results will inform the advice given to patients regarding the resolution of their symptoms. The recovery model described here will facilitate the use of symptom recovery as an outcome measure in future clinical trials.

AB - Our aims were to address three fundamental questions relating to the symptoms of community-acquired pneumonia (CAP): Do patients completely recover from pneumonia symptoms? How long does this recovery take? Which factors influence symptomatic recovery?We prospectively recruited patients at two hospitals in Liverpool, UK, into a longitudinal, observational cohort study and modelled symptom recovery from CAP. We excluded patients with cancer, immunosuppression or advanced dementia, and those who were intubated or palliated from admission. We derived a statistical model to describe symptom patterns.We recruited 169 (52% male) adults. Multivariable analysis demonstrated that the time taken to recover to baseline was determined by the initial severity of symptoms. Severity of symptoms was associated with comorbidity and was inversely related to age. The pattern of symptom recovery was exponential and most patients' symptoms returned to baseline by 10 days.These results will inform the advice given to patients regarding the resolution of their symptoms. The recovery model described here will facilitate the use of symptom recovery as an outcome measure in future clinical trials.

U2 - 10.1183/13993003.02170-2016

DO - 10.1183/13993003.02170-2016

M3 - Journal article

C2 - 28619956

VL - 49

JO - European Respiratory Journal

JF - European Respiratory Journal

SN - 0903-1936

IS - 6

M1 - 1602170

ER -