A model for leptospire dynamics and control in the Norway rat (Rattus norvegicus) the reservoir host in urban slum environments

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https://doi.org/10.1016/j.epidem.2018.05.002
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Available under license: CC BY: Creative Commons Attribution 4.0 International License

Keywords

Leptospirosis, Norway rats, target reproduction number

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A model for leptospire dynamics and control in the Norway rat (Rattus norvegicus) the reservoir host in urban slum environments. / Minter, Amanda; Diggle, Peter J.; Costa, Federico et al.
In: Epidemics, Vol. 25, 12.2018, p. 26-34.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Bibtex

@article{4e88dc0c12694f7a981186842817524b,

title = "A model for leptospire dynamics and control in the Norway rat (Rattus norvegicus) the reservoir host in urban slum environments",

abstract = "Leptospirosis is a zoonosis that humans can contract via contact with animal reservoirs directly or with water contaminated with their urine. The primary reservoir of pathogenic leptospires within urban slum environments is the Norway rat (Rattus norvegicus). Motivated by the annual outbreaks of human leptospirosis in slum urban settings, the within population infection dynamics of the Norway rat were investigated in Pau da Lima, an community in Salvador, Brazil. A mechanistic model of the dynamics of leptospire infection was informed by extensive field and laboratory data was developed and explored analytically. To identify the intraspecific transmission route of most importance, a global sensitivity analysis of the basic reproduction number to its components was performed. In addition, different methods of rodent control were investigated by calculating target reproduction numbers. Our results suggest environmental transmission plays an important role in the maintenance of infection in the rodent population. To control numbers of wild Norway rats, combinations of controls are recommended but environmental control should also be investigated to reduce prevalence of infection in rats.",

keywords = "Leptospirosis, Norway rats, target reproduction number",

author = "Amanda Minter and Diggle, {Peter J.} and Federico Costa and James Childs and Ko, {Albert I.} and Mike Begon",

year = "2018",

month = dec,

doi = "10.1016/j.epidem.2018.05.002",

language = "English",

volume = "25",

pages = "26--34",

journal = "Epidemics",

issn = "1755-4365",

publisher = "ELSEVIER SCIENCE BV",

}

RIS

TY - JOUR

T1 - A model for leptospire dynamics and control in the Norway rat (Rattus norvegicus) the reservoir host in urban slum environments

AU - Minter, Amanda

AU - Diggle, Peter J.

AU - Costa, Federico

AU - Childs, James

AU - Ko, Albert I.

AU - Begon, Mike

PY - 2018/12

Y1 - 2018/12

N2 - Leptospirosis is a zoonosis that humans can contract via contact with animal reservoirs directly or with water contaminated with their urine. The primary reservoir of pathogenic leptospires within urban slum environments is the Norway rat (Rattus norvegicus). Motivated by the annual outbreaks of human leptospirosis in slum urban settings, the within population infection dynamics of the Norway rat were investigated in Pau da Lima, an community in Salvador, Brazil. A mechanistic model of the dynamics of leptospire infection was informed by extensive field and laboratory data was developed and explored analytically. To identify the intraspecific transmission route of most importance, a global sensitivity analysis of the basic reproduction number to its components was performed. In addition, different methods of rodent control were investigated by calculating target reproduction numbers. Our results suggest environmental transmission plays an important role in the maintenance of infection in the rodent population. To control numbers of wild Norway rats, combinations of controls are recommended but environmental control should also be investigated to reduce prevalence of infection in rats.

AB - Leptospirosis is a zoonosis that humans can contract via contact with animal reservoirs directly or with water contaminated with their urine. The primary reservoir of pathogenic leptospires within urban slum environments is the Norway rat (Rattus norvegicus). Motivated by the annual outbreaks of human leptospirosis in slum urban settings, the within population infection dynamics of the Norway rat were investigated in Pau da Lima, an community in Salvador, Brazil. A mechanistic model of the dynamics of leptospire infection was informed by extensive field and laboratory data was developed and explored analytically. To identify the intraspecific transmission route of most importance, a global sensitivity analysis of the basic reproduction number to its components was performed. In addition, different methods of rodent control were investigated by calculating target reproduction numbers. Our results suggest environmental transmission plays an important role in the maintenance of infection in the rodent population. To control numbers of wild Norway rats, combinations of controls are recommended but environmental control should also be investigated to reduce prevalence of infection in rats.

KW - Leptospirosis

KW - Norway rats

KW - target reproduction number

U2 - 10.1016/j.epidem.2018.05.002

DO - 10.1016/j.epidem.2018.05.002

M3 - Journal article

VL - 25

SP - 26

EP - 34

JO - Epidemics

JF - Epidemics

SN - 1755-4365

ER -

Research

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