A monoclonal antibody to common acute lymphoblastic leukemia antigen (neutral endopeptidase) immunostains senile plaques in the brains of patients with Alzheimer's disease

Biomedical and Life Sciences

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https://doi.org/10.1016/0304-3940(91)90702-U
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Keywords

Aged, Aged, 80 and over, Alzheimer Disease, Amyloid, Antibodies, Monoclonal, Antigens, Neoplasm, Brain, Endopeptidases, Humans, Immunoenzyme Techniques, Immunohistochemistry, Middle Aged, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Staining and Labeling

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A monoclonal antibody to common acute lymphoblastic leukemia antigen (neutral endopeptidase) immunostains senile plaques in the brains of patients with Alzheimer's disease. / Sato, M; Ikeda, K; Haga, S et al.
In: Neuroscience Letters, Vol. 121, No. 1-2, 02.01.1991, p. 271-273.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Bibtex

@article{1dd3a79bdd864628919425df0e76a82b,

title = "A monoclonal antibody to common acute lymphoblastic leukemia antigen (neutral endopeptidase) immunostains senile plaques in the brains of patients with Alzheimer's disease",

abstract = "We immunostained brain tissues of patients with Alzheimer's disease (AD) together with non-demented aged and younger controls with a battery of anti-human hemopoietic cell monoclonal antibodies (OK series, Ortho Diagnostics Co., Ltd. and some others) by the avidin-biotin-peroxidase complex (ABC) method to see if any epitopes are shared with the nervous system or might contribute to the neurodegenerative changes in this disease. One out of 29 monoclonal antibodies, OKBcALLa, which recognizes common acute lymphocytic leukemia antigen (CALLA, CD10), immunostained senile plaques in the brains of patients with AD. The pattern and intensity of this staining, using cryopreserved samples, was almost identical to that obtained with anti beta-protein. Thus, senile plaques in the Alzheimer's brain share an epitope with CALLA.",

keywords = "Aged, Aged, 80 and over, Alzheimer Disease, Amyloid, Antibodies, Monoclonal, Antigens, Neoplasm, Brain, Endopeptidases, Humans, Immunoenzyme Techniques, Immunohistochemistry, Middle Aged, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Staining and Labeling",

author = "M Sato and K Ikeda and S Haga and D Allsop and T Ishii",

year = "1991",

month = jan,

day = "2",

doi = "10.1016/0304-3940(91)90702-U",

language = "English",

volume = "121",

pages = "271--273",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "ELSEVIER IRELAND LTD",

number = "1-2",

}

RIS

TY - JOUR

T1 - A monoclonal antibody to common acute lymphoblastic leukemia antigen (neutral endopeptidase) immunostains senile plaques in the brains of patients with Alzheimer's disease

AU - Sato, M

AU - Ikeda, K

AU - Haga, S

AU - Allsop, D

AU - Ishii, T

PY - 1991/1/2

Y1 - 1991/1/2

N2 - We immunostained brain tissues of patients with Alzheimer's disease (AD) together with non-demented aged and younger controls with a battery of anti-human hemopoietic cell monoclonal antibodies (OK series, Ortho Diagnostics Co., Ltd. and some others) by the avidin-biotin-peroxidase complex (ABC) method to see if any epitopes are shared with the nervous system or might contribute to the neurodegenerative changes in this disease. One out of 29 monoclonal antibodies, OKBcALLa, which recognizes common acute lymphocytic leukemia antigen (CALLA, CD10), immunostained senile plaques in the brains of patients with AD. The pattern and intensity of this staining, using cryopreserved samples, was almost identical to that obtained with anti beta-protein. Thus, senile plaques in the Alzheimer's brain share an epitope with CALLA.

AB - We immunostained brain tissues of patients with Alzheimer's disease (AD) together with non-demented aged and younger controls with a battery of anti-human hemopoietic cell monoclonal antibodies (OK series, Ortho Diagnostics Co., Ltd. and some others) by the avidin-biotin-peroxidase complex (ABC) method to see if any epitopes are shared with the nervous system or might contribute to the neurodegenerative changes in this disease. One out of 29 monoclonal antibodies, OKBcALLa, which recognizes common acute lymphocytic leukemia antigen (CALLA, CD10), immunostained senile plaques in the brains of patients with AD. The pattern and intensity of this staining, using cryopreserved samples, was almost identical to that obtained with anti beta-protein. Thus, senile plaques in the Alzheimer's brain share an epitope with CALLA.

KW - Aged

KW - Aged, 80 and over

KW - Alzheimer Disease

KW - Amyloid

KW - Antibodies, Monoclonal

KW - Antigens, Neoplasm

KW - Brain

KW - Endopeptidases

KW - Humans

KW - Immunoenzyme Techniques

KW - Immunohistochemistry

KW - Middle Aged

KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma

KW - Staining and Labeling

U2 - 10.1016/0304-3940(91)90702-U

DO - 10.1016/0304-3940(91)90702-U

M3 - Journal article

C2 - 1708483

VL - 121

SP - 271

EP - 273

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1-2

ER -

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