A mosaic cell layer in human pregnancy.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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A mosaic cell layer in human pregnancy. / Byrne, S.; Challis, E.; Williams, J. L. R. et al.
In: Placenta, Vol. 31, No. 5, 05.2010, p. 373-379.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Byrne, S, Challis, E, Williams, JLR, Pringle, JH, Hennessy, JM & Ockleford, CD 2010, 'A mosaic cell layer in human pregnancy.', Placenta, vol. 31, no. 5, pp. 373-379. https://doi.org/10.1016/j.placenta.2010.02.005

APA

Byrne, S., Challis, E., Williams, J. L. R., Pringle, J. H., Hennessy, J. M., & Ockleford, C. D. (2010). A mosaic cell layer in human pregnancy. Placenta, 31(5), 373-379. https://doi.org/10.1016/j.placenta.2010.02.005

Vancouver

Byrne S, Challis E, Williams JLR, Pringle JH, Hennessy JM, Ockleford CD. A mosaic cell layer in human pregnancy. Placenta. 2010 May;31(5):373-379. doi: 10.1016/j.placenta.2010.02.005

Author

Byrne, S. ; Challis, E. ; Williams, J. L. R. et al. / A mosaic cell layer in human pregnancy. In: Placenta. 2010 ; Vol. 31, No. 5. pp. 373-379.

Bibtex

@article{bf9435fab21741eabbe63c61f336d7f5,

title = "A mosaic cell layer in human pregnancy.",

abstract = "We present evidence for a novel histological and embryological relationship at the human materno-fetal interface. Here an epi- endo- thelium forms an integrated unicellular layer lining the intervillus space in between the anchoring villi that attach the placenta to the uterus. This layer appears to be derived from two different germ layers (mesoderm and ectoderm). The data presented here reveals that when a probe for the Y-chromosome is used to test the gender of placental cells following the birth of male or female babies, the cell-sheet is a genetic mosaic derived from two individuals (mother and baby). The endothelium is maternally derived; the epithelium is fetal derived. This new allo- epi- endothelium model is relevant to theories of germ layer separation in development, reproductive immunology and the endocrinology of implantation and placentation. It demonstrates cooperative intercellular interactions that are fundamental to achieving a major goal of human interstitial implantation the establishment of a blood sinus for haematotrophic nutrition. Poor implantation is a fundamental cause of pregnancy pathology and this knowledge will be useful in development of our understanding of pregnancy diseases.",

keywords = "Germ layers, Placenta, Pregnancy, Basal plate, Extra-embryonic membranes, Materno-fetal interaction",

author = "S. Byrne and E. Challis and Williams, {J. L. R.} and Pringle, {J. H.} and Hennessy, {J. M.} and Ockleford, {Colin D.}",

year = "2010",

month = may,

doi = "10.1016/j.placenta.2010.02.005",

language = "English",

volume = "31",

pages = "373--379",

journal = "Placenta",

issn = "0143-4004",

publisher = "Elsevier",

number = "5",

}

RIS

TY - JOUR

T1 - A mosaic cell layer in human pregnancy.

AU - Byrne, S.

AU - Challis, E.

AU - Williams, J. L. R.

AU - Pringle, J. H.

AU - Hennessy, J. M.

AU - Ockleford, Colin D.

PY - 2010/5

Y1 - 2010/5

N2 - We present evidence for a novel histological and embryological relationship at the human materno-fetal interface. Here an epi- endo- thelium forms an integrated unicellular layer lining the intervillus space in between the anchoring villi that attach the placenta to the uterus. This layer appears to be derived from two different germ layers (mesoderm and ectoderm). The data presented here reveals that when a probe for the Y-chromosome is used to test the gender of placental cells following the birth of male or female babies, the cell-sheet is a genetic mosaic derived from two individuals (mother and baby). The endothelium is maternally derived; the epithelium is fetal derived. This new allo- epi- endothelium model is relevant to theories of germ layer separation in development, reproductive immunology and the endocrinology of implantation and placentation. It demonstrates cooperative intercellular interactions that are fundamental to achieving a major goal of human interstitial implantation the establishment of a blood sinus for haematotrophic nutrition. Poor implantation is a fundamental cause of pregnancy pathology and this knowledge will be useful in development of our understanding of pregnancy diseases.

AB - We present evidence for a novel histological and embryological relationship at the human materno-fetal interface. Here an epi- endo- thelium forms an integrated unicellular layer lining the intervillus space in between the anchoring villi that attach the placenta to the uterus. This layer appears to be derived from two different germ layers (mesoderm and ectoderm). The data presented here reveals that when a probe for the Y-chromosome is used to test the gender of placental cells following the birth of male or female babies, the cell-sheet is a genetic mosaic derived from two individuals (mother and baby). The endothelium is maternally derived; the epithelium is fetal derived. This new allo- epi- endothelium model is relevant to theories of germ layer separation in development, reproductive immunology and the endocrinology of implantation and placentation. It demonstrates cooperative intercellular interactions that are fundamental to achieving a major goal of human interstitial implantation the establishment of a blood sinus for haematotrophic nutrition. Poor implantation is a fundamental cause of pregnancy pathology and this knowledge will be useful in development of our understanding of pregnancy diseases.

KW - Germ layers

KW - Placenta

KW - Pregnancy

KW - Basal plate

KW - Extra-embryonic membranes

KW - Materno-fetal interaction

UR - http://www.scopus.com/inward/record.url?scp=77951979017&partnerID=8YFLogxK

U2 - 10.1016/j.placenta.2010.02.005

DO - 10.1016/j.placenta.2010.02.005

M3 - Journal article

VL - 31

SP - 373

EP - 379

JO - Placenta

JF - Placenta

SN - 0143-4004

IS - 5

ER -

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