Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - A multicenter prospective study of early gestational diabetes mellitus
T2 - rates, severity and risk factors based on IADPSG defined fasting glycemia
AU - Olagbuji, Biodun Nelson
AU - Aderoba, Adeniyi Kolade
AU - Olagbuji, Yetunde Winifred
AU - Enikuomehin, Adenike Christianah
AU - Adewole, Ayodele Stephen
AU - Awe, Olayemi Christianah
AU - Akadiri, Olumide
PY - 2022/2/18
Y1 - 2022/2/18
N2 - ObjectiveTo describe the epidemiology of early gestational diabetes mellitus (GDM) based on the International Association of Diabetes and Pregnancy Study Groups (IADPSG) defined fasting glycemia.MethodsA prospective multicenter study testing fasting venous plasma glucose (FPG) in women aged 18–45 years between 6 and 23+6 weeks of pregnancy in secondary health facilities in Ondo State, Nigeria. Early GDM was defined using the IADPSG threshold for fasting hyperglycemia, and its severity was examined. Potential risk factors for early GDM were assessed using logistic regression analysis.ResultsOf the 8915 women who underwent FPG testing, the prevalence of early GDM was 12.5% (11.9%–13.3%). Multivariable analysis identified a dose–response association between body mass index (BMI) (calculated as weight in kilograms divided by the square of height in meters) and early GDM, with a BMI of 35 or more (adjusted odds ratio [aOR] 1.92, 95% confidence interval [CI] 1.03–3.55) associated with early GDM. Primiparity (aOR 1.49, 95% CI 1.25–1.76), multiparity (aOR 1.73, 95% CI 1.47–2.04), and a first-degree family history of diabetes (aOR 1.60, 95% CI 1.27–2.02) were associated with significantly higher odds of early GDM.ConclusionThis study established the prevalence, severity and risk factors for early GDM in a specific country that potentially represents a global region with no previous relevant data.
AB - ObjectiveTo describe the epidemiology of early gestational diabetes mellitus (GDM) based on the International Association of Diabetes and Pregnancy Study Groups (IADPSG) defined fasting glycemia.MethodsA prospective multicenter study testing fasting venous plasma glucose (FPG) in women aged 18–45 years between 6 and 23+6 weeks of pregnancy in secondary health facilities in Ondo State, Nigeria. Early GDM was defined using the IADPSG threshold for fasting hyperglycemia, and its severity was examined. Potential risk factors for early GDM were assessed using logistic regression analysis.ResultsOf the 8915 women who underwent FPG testing, the prevalence of early GDM was 12.5% (11.9%–13.3%). Multivariable analysis identified a dose–response association between body mass index (BMI) (calculated as weight in kilograms divided by the square of height in meters) and early GDM, with a BMI of 35 or more (adjusted odds ratio [aOR] 1.92, 95% confidence interval [CI] 1.03–3.55) associated with early GDM. Primiparity (aOR 1.49, 95% CI 1.25–1.76), multiparity (aOR 1.73, 95% CI 1.47–2.04), and a first-degree family history of diabetes (aOR 1.60, 95% CI 1.27–2.02) were associated with significantly higher odds of early GDM.ConclusionThis study established the prevalence, severity and risk factors for early GDM in a specific country that potentially represents a global region with no previous relevant data.
KW - early gestational diabetes mellitus
KW - fasting hyperglycemia
KW - fasting plasma glucose
KW - overt diabetes
KW - pregnancy
U2 - 10.1002/ijgo.14102
DO - 10.1002/ijgo.14102
M3 - Journal article
JO - International Journal of Gynecology & Obstetrics
JF - International Journal of Gynecology & Obstetrics
SN - 0020-7292
ER -