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A Proteogenomic Approach for the Identification of Virulence Factors in Leishmania Parasites

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A Proteogenomic Approach for the Identification of Virulence Factors in Leishmania Parasites. / Munjal, N.S.; Dey, G.; Parthasarathi, K.T.S. et al.
Protogenomics. ed. / J. Allmer; A. Kumar. New York: Humana Press, 2024. p. 279-296 ( Methods in Molecular Biology; Vol. 2859).

Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter

Harvard

Munjal, NS, Dey, G, Parthasarathi, KTS, Chauhan, K, Pai, K, Patole, MS, Pawar, H & Sharma, J 2024, A Proteogenomic Approach for the Identification of Virulence Factors in Leishmania Parasites. in J Allmer & A Kumar (eds), Protogenomics. Methods in Molecular Biology, vol. 2859, Humana Press, New York, pp. 279-296. https://doi.org/10.1007/978-1-0716-4152-1_16

APA

Munjal, N. S., Dey, G., Parthasarathi, K. T. S., Chauhan, K., Pai, K., Patole, M. S., Pawar, H., & Sharma, J. (2024). A Proteogenomic Approach for the Identification of Virulence Factors in Leishmania Parasites. In J. Allmer, & A. Kumar (Eds.), Protogenomics (pp. 279-296). ( Methods in Molecular Biology; Vol. 2859). Humana Press. https://doi.org/10.1007/978-1-0716-4152-1_16

Vancouver

Munjal NS, Dey G, Parthasarathi KTS, Chauhan K, Pai K, Patole MS et al. A Proteogenomic Approach for the Identification of Virulence Factors in Leishmania Parasites. In Allmer J, Kumar A, editors, Protogenomics. New York: Humana Press. 2024. p. 279-296. ( Methods in Molecular Biology). doi: 10.1007/978-1-0716-4152-1_16

Author

Munjal, N.S. ; Dey, G. ; Parthasarathi, K.T.S. et al. / A Proteogenomic Approach for the Identification of Virulence Factors in Leishmania Parasites. Protogenomics. editor / J. Allmer ; A. Kumar. New York : Humana Press, 2024. pp. 279-296 ( Methods in Molecular Biology).

Bibtex

@inbook{d23df7b9013449c4b4c2a93c5e3bc5b7,
title = "A Proteogenomic Approach for the Identification of Virulence Factors in Leishmania Parasites",
abstract = "Identifying new genes involved in virulence and drug resistance may hold the key to a better understanding of parasitic diseases. The proteogenomic profiling of various Leishmania species, the causative agents of leishmaniasis, has identified several novel genes, N- and C-terminal extensions of proteins, and corrections of existing gene models. Various virulence factors (VFs) responsible for leishmaniasis have been previously annotated through a proteogenomic approach, including the C-terminal extension of heat shock protein 70 (HSP70). Furthermore, the diversity of VFs across Leishmania donovani, L. infantum, L. major, and L. mexicana was determined using phylogenetic analysis. Moreover, protein–protein interaction networks (PPINs) of VFs with HSPs aid in making significant biological interpretations. Overall, an integrated omics approach involving proteogenomics was used to identify and study the relationship among VFs with other interacting proteins, including HSPs. This chapter provides a step-by-step guide to the identification of new genes in Leishmania using a proteogenomic approach and their functional assignment using a bioinformatics-based approach.",
author = "N.S. Munjal and G. Dey and K.T.S. Parthasarathi and K. Chauhan and K. Pai and M.S. Patole and H. Pawar and J. Sharma",
year = "2024",
month = oct,
day = "23",
doi = "10.1007/978-1-0716-4152-1_16",
language = "English",
isbn = "9781071641514",
series = " Methods in Molecular Biology",
publisher = "Humana Press",
pages = "279--296",
editor = "J. Allmer and A. Kumar",
booktitle = "Protogenomics",

}

RIS

TY - CHAP

T1 - A Proteogenomic Approach for the Identification of Virulence Factors in Leishmania Parasites

AU - Munjal, N.S.

AU - Dey, G.

AU - Parthasarathi, K.T.S.

AU - Chauhan, K.

AU - Pai, K.

AU - Patole, M.S.

AU - Pawar, H.

AU - Sharma, J.

PY - 2024/10/23

Y1 - 2024/10/23

N2 - Identifying new genes involved in virulence and drug resistance may hold the key to a better understanding of parasitic diseases. The proteogenomic profiling of various Leishmania species, the causative agents of leishmaniasis, has identified several novel genes, N- and C-terminal extensions of proteins, and corrections of existing gene models. Various virulence factors (VFs) responsible for leishmaniasis have been previously annotated through a proteogenomic approach, including the C-terminal extension of heat shock protein 70 (HSP70). Furthermore, the diversity of VFs across Leishmania donovani, L. infantum, L. major, and L. mexicana was determined using phylogenetic analysis. Moreover, protein–protein interaction networks (PPINs) of VFs with HSPs aid in making significant biological interpretations. Overall, an integrated omics approach involving proteogenomics was used to identify and study the relationship among VFs with other interacting proteins, including HSPs. This chapter provides a step-by-step guide to the identification of new genes in Leishmania using a proteogenomic approach and their functional assignment using a bioinformatics-based approach.

AB - Identifying new genes involved in virulence and drug resistance may hold the key to a better understanding of parasitic diseases. The proteogenomic profiling of various Leishmania species, the causative agents of leishmaniasis, has identified several novel genes, N- and C-terminal extensions of proteins, and corrections of existing gene models. Various virulence factors (VFs) responsible for leishmaniasis have been previously annotated through a proteogenomic approach, including the C-terminal extension of heat shock protein 70 (HSP70). Furthermore, the diversity of VFs across Leishmania donovani, L. infantum, L. major, and L. mexicana was determined using phylogenetic analysis. Moreover, protein–protein interaction networks (PPINs) of VFs with HSPs aid in making significant biological interpretations. Overall, an integrated omics approach involving proteogenomics was used to identify and study the relationship among VFs with other interacting proteins, including HSPs. This chapter provides a step-by-step guide to the identification of new genes in Leishmania using a proteogenomic approach and their functional assignment using a bioinformatics-based approach.

U2 - 10.1007/978-1-0716-4152-1_16

DO - 10.1007/978-1-0716-4152-1_16

M3 - Chapter

SN - 9781071641514

T3 - Methods in Molecular Biology

SP - 279

EP - 296

BT - Protogenomics

A2 - Allmer, J.

A2 - Kumar, A.

PB - Humana Press

CY - New York

ER -