A review on nanostructure-based mercury (II) detection and monitoring focusing on aptamer and oligonucleotide biosensors

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https://doi.org/10.1016/j.talanta.2020.121437
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Keywords

Aptamers, Biosensors, Hg detection, Nanomaterials, Oligonucleotide probes

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A review on nanostructure-based mercury (II) detection and monitoring focusing on aptamer and oligonucleotide biosensors. / Şahin, Samet; Caglayan, Mustafa Oguzhan; Üstündağ, Zafer.
In: Talanta, Vol. 220, 121437, 01.12.2020.

Research output: Contribution to Journal/Magazine › Review article › peer-review

Bibtex

@article{0c8cf63ab320447784ba042c5b73e079,

title = "A review on nanostructure-based mercury (II) detection and monitoring focusing on aptamer and oligonucleotide biosensors",

abstract = "Heavy metal ion pollution is a severe problem in environmental protection and especially in human health due to their bioaccumulation in organisms. Mercury (II) (Hg2+), even at low concentrations, can lead to DNA damage and give permanent harm to the central nervous system by easily passing through biological membranes. Therefore, sensitive detection and monitoring of Hg2+ is of particular interest with significant specificity. In this review, aptamer-based strategies in combination with nanostructures as well as several other strategies to solve addressed problems in sensor development for Hg2+ are discussed in detail. In particular, the analytical performance of different aptamer and oligonucleotide-based strategies using different signal improvement approaches based on nanoparticles were compared within each strategy and in between. Although quite a number of the suggested methodologies analyzed in this review fulfills the standard requirements, further development is still needed on real sample analysis and analytical performance parameters.",

keywords = "Aptamers, Biosensors, Hg detection, Nanomaterials, Oligonucleotide probes",

author = "Samet {\c S}ahin and Caglayan, {Mustafa Oguzhan} and Zafer {\"U}st{\"u}ndağ",

year = "2020",

month = dec,

day = "1",

doi = "10.1016/j.talanta.2020.121437",

language = "English",

volume = "220",

journal = "Talanta",

issn = "0039-9140",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - A review on nanostructure-based mercury (II) detection and monitoring focusing on aptamer and oligonucleotide biosensors

AU - Şahin, Samet

AU - Caglayan, Mustafa Oguzhan

AU - Üstündağ, Zafer

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Heavy metal ion pollution is a severe problem in environmental protection and especially in human health due to their bioaccumulation in organisms. Mercury (II) (Hg2+), even at low concentrations, can lead to DNA damage and give permanent harm to the central nervous system by easily passing through biological membranes. Therefore, sensitive detection and monitoring of Hg2+ is of particular interest with significant specificity. In this review, aptamer-based strategies in combination with nanostructures as well as several other strategies to solve addressed problems in sensor development for Hg2+ are discussed in detail. In particular, the analytical performance of different aptamer and oligonucleotide-based strategies using different signal improvement approaches based on nanoparticles were compared within each strategy and in between. Although quite a number of the suggested methodologies analyzed in this review fulfills the standard requirements, further development is still needed on real sample analysis and analytical performance parameters.

AB - Heavy metal ion pollution is a severe problem in environmental protection and especially in human health due to their bioaccumulation in organisms. Mercury (II) (Hg2+), even at low concentrations, can lead to DNA damage and give permanent harm to the central nervous system by easily passing through biological membranes. Therefore, sensitive detection and monitoring of Hg2+ is of particular interest with significant specificity. In this review, aptamer-based strategies in combination with nanostructures as well as several other strategies to solve addressed problems in sensor development for Hg2+ are discussed in detail. In particular, the analytical performance of different aptamer and oligonucleotide-based strategies using different signal improvement approaches based on nanoparticles were compared within each strategy and in between. Although quite a number of the suggested methodologies analyzed in this review fulfills the standard requirements, further development is still needed on real sample analysis and analytical performance parameters.

KW - Aptamers

KW - Biosensors

KW - Hg detection

KW - Nanomaterials

KW - Oligonucleotide probes

U2 - 10.1016/j.talanta.2020.121437

DO - 10.1016/j.talanta.2020.121437

M3 - Review article

C2 - 32928439

AN - SCOPUS:85088658794

VL - 220

JO - Talanta

JF - Talanta

SN - 0039-9140

M1 - 121437

ER -

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