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A ‘Sleeping Trojan Horse’ which transports metal ions into cells, localises in nucleoli, and has potential for bimodal fluorescence/PET imaging

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published
  • Flora L. Thorp-Greenwood
  • Vanesa Fernandez-Moreira
  • Coralie Millet
  • Catrin F. Williams
  • Joanne Cable
  • Jonathan B. Court
  • Anthony J. Hayes
  • David Lloyd
  • Michael Coogan
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<mark>Journal publication date</mark>2011
<mark>Journal</mark>Chemical Communications
Issue number11
Volume47
Number of pages3
Pages (from-to)3096-3098
Publication StatusPublished
<mark>Original language</mark>English

Abstract

A rhenium polypyridine-based molecular vessel is membrane impermeant when empty, but, upon loading with metal ions, the cationic form is taken up by MCF-7 cells, localising in nucleoli. The luminescence of the vessel and its copper binding ability suggest potential as a bimodal fluorescence/PET imaging agent.