Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - A study of the effect of precursors on physical and biological properties of mesoporous bioactive glass
AU - Shah, A.T.
AU - Ain, Q.
AU - Chaudhry, A.A.
AU - Khan, A.F.
AU - Iqbal, B.
AU - Ahmad, S.
AU - Siddiqi, S.A.
AU - Rehman, I.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - A novel mesoporous bioactive glass (MBG) of composition 64SiO 2 –26CaO–10P 2 O 5 (mol %) was prepared by hydrothermal method using H 3 PO 4 as a precursor for P 2 O 5 . The effect of use of organic triethylphosphate (TEP) and inorganic H 3 PO 4 in MBG synthesis on glass transition temperature (T g ), crystallinity, morphology and bioactivity of MBGs was studied. Phase purity determination and structural analysis were done using powder X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy, respectively. XRD revealed that MBG prepared from H 3 PO 4 (MBG-H 3 PO 4 ) when sintered at 700 °C was partially glassy/amorphous in nature and contained a mixture of crystalline apatite, wollastonite, calcium phosphate and calcium silicate phases. Calcined MBG prepared from TEP (MBG-TEP) contained only wollastonite and calcium silicate phases. Particle size and surface area determined by BET surface area analysis showed higher surface area (310 m 2 g −1 ) for MBG-H 3 PO 4 as compared to MBG-TEP (86 m 2 g −1 ). It also had a smaller particle size (20 nm) and 70 % higher pore volume (0.88 cm 3 g −1 ) for MBG-H 3 PO 4 as compared to MBG-TEP (60 nm particle size and 0.23 cm 3 g −1 pore volume). Thermal studies showed that use of H 3 PO 4 decreases T g and increased ΔT (difference between T g and crystallization initiation temperature Tc o ). Low T g and high ΔT also enhanced bioactivity of MBGs. Bioactivity was determined by immersion in a simulated body fluid for varying time intervals for a maximum period of 14 days. It revealed enhanced bioactivity, as evident by the formation of apatite layer on the surface, for MBG-H 3 PO 4 as compared to MBG-TEP. Scanning electron microscopy and FTIR spectroscopy also supported this observation. Antibacterial studies with Escherichia Coli bacteria, MBG-H 3 PO 4 showed better antibacterial behaviour than MBG-TEP. © 2014, Springer Science+Business Media New York.
AB - A novel mesoporous bioactive glass (MBG) of composition 64SiO 2 –26CaO–10P 2 O 5 (mol %) was prepared by hydrothermal method using H 3 PO 4 as a precursor for P 2 O 5 . The effect of use of organic triethylphosphate (TEP) and inorganic H 3 PO 4 in MBG synthesis on glass transition temperature (T g ), crystallinity, morphology and bioactivity of MBGs was studied. Phase purity determination and structural analysis were done using powder X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy, respectively. XRD revealed that MBG prepared from H 3 PO 4 (MBG-H 3 PO 4 ) when sintered at 700 °C was partially glassy/amorphous in nature and contained a mixture of crystalline apatite, wollastonite, calcium phosphate and calcium silicate phases. Calcined MBG prepared from TEP (MBG-TEP) contained only wollastonite and calcium silicate phases. Particle size and surface area determined by BET surface area analysis showed higher surface area (310 m 2 g −1 ) for MBG-H 3 PO 4 as compared to MBG-TEP (86 m 2 g −1 ). It also had a smaller particle size (20 nm) and 70 % higher pore volume (0.88 cm 3 g −1 ) for MBG-H 3 PO 4 as compared to MBG-TEP (60 nm particle size and 0.23 cm 3 g −1 pore volume). Thermal studies showed that use of H 3 PO 4 decreases T g and increased ΔT (difference between T g and crystallization initiation temperature Tc o ). Low T g and high ΔT also enhanced bioactivity of MBGs. Bioactivity was determined by immersion in a simulated body fluid for varying time intervals for a maximum period of 14 days. It revealed enhanced bioactivity, as evident by the formation of apatite layer on the surface, for MBG-H 3 PO 4 as compared to MBG-TEP. Scanning electron microscopy and FTIR spectroscopy also supported this observation. Antibacterial studies with Escherichia Coli bacteria, MBG-H 3 PO 4 showed better antibacterial behaviour than MBG-TEP. © 2014, Springer Science+Business Media New York.
KW - Apatite
KW - Bioactivity
KW - Calcium
KW - Calcium silicate
KW - Escherichia coli
KW - Fourier transform infrared spectroscopy
KW - Glass transition
KW - Particle size
KW - Particle size analysis
KW - Scanning electron microscopy
KW - Silicate minerals
KW - Sintering
KW - X ray diffraction
KW - Anti-bacterial studies
KW - Biological properties
KW - Escherichia coli bacteria
KW - Initiation temperature
KW - Mesoporous bioactive glass
KW - Particle size and surfaces
KW - Powder X ray diffraction
KW - Simulated body fluids
KW - Bioactive glass
U2 - 10.1007/s10853-014-8742-x
DO - 10.1007/s10853-014-8742-x
M3 - Journal article
VL - 50
SP - 1794
EP - 1804
JO - Journal of Materials Science
JF - Journal of Materials Science
SN - 0022-2461
IS - 4
ER -