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Adenosine-to-Inosine RNA Editing in Health and Disease

Research output: Contribution to Journal/Magazine › Review article › peer-review

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Adenosine-to-Inosine RNA Editing in Health and Disease. / Gatsiou, Aikaterini; Vlachogiannis, Nikolaos; Lunella, Federica Francesca et al.
In: Antioxidants and Redox Signaling, Vol. 29, No. 9, 20.09.2018, p. 846-863.

Research output: Contribution to Journal/Magazine › Review article › peer-review

Harvard

Gatsiou, A, Vlachogiannis, N, Lunella, FF, Sachse, M & Stellos, K 2018, 'Adenosine-to-Inosine RNA Editing in Health and Disease', Antioxidants and Redox Signaling, vol. 29, no. 9, pp. 846-863. https://doi.org/10.1089/ars.2017.7295

APA

Gatsiou, A., Vlachogiannis, N., Lunella, F. F., Sachse, M., & Stellos, K. (2018). Adenosine-to-Inosine RNA Editing in Health and Disease. Antioxidants and Redox Signaling, 29(9), 846-863. https://doi.org/10.1089/ars.2017.7295

Vancouver

Gatsiou A, Vlachogiannis N, Lunella FF, Sachse M, Stellos K. Adenosine-to-Inosine RNA Editing in Health and Disease. Antioxidants and Redox Signaling. 2018 Sept 20;29(9):846-863. doi: 10.1089/ars.2017.7295

Author

Gatsiou, Aikaterini ; Vlachogiannis, Nikolaos ; Lunella, Federica Francesca et al. / Adenosine-to-Inosine RNA Editing in Health and Disease. In: Antioxidants and Redox Signaling. 2018 ; Vol. 29, No. 9. pp. 846-863.

Bibtex

@article{3641edd4f0dd4c0ebecc8a767eb311a2,
title = "Adenosine-to-Inosine RNA Editing in Health and Disease",
abstract = "SIGNIFICANCE: Adenosine deamination in transcriptome results in the formation of inosine, a process that is called A-to-I RNA editing. Adenosine deamination is one of the more than 140 described RNA modifications. A-to-I RNA editing is catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes and is essential for life. Recent Advances: Accumulating evidence supports a critical role of RNA editing in all aspects of RNA metabolism, including mRNA stability, splicing, nuclear export, and localization, as well as in recoding of proteins. These advances have significantly enhanced the understanding of mechanisms involved in development and in homeostasis. Furthermore, recent studies have indicated that RNA editing may be critically involved in cancer, aging, neurological, autoimmune, or cardiovascular diseases.CRITICAL ISSUES: This review summarizes recent and significant achievements in the field of A-to-I RNA editing and discusses the importance and translational value of this RNA modification for gene expression, cellular, and organ function, as well as for disease development.FUTURE DIRECTIONS: Elucidation of the exact RNA editing-dependent mechanisms in a single-nucleotide level may pave the path toward the development of novel therapeutic strategies focusing on modulation of ADAR function in the disease context. Antioxid. Redox Signal. 29, 846-863.",
keywords = "Adenosine/genetics, Animals, Deamination, Disease/genetics, Homeostasis/genetics, Humans, Inosine/genetics, RNA/genetics, RNA Editing/genetics",
author = "Aikaterini Gatsiou and Nikolaos Vlachogiannis and Lunella, {Federica Francesca} and Marco Sachse and Konstantinos Stellos",
year = "2018",
month = sep,
day = "20",
doi = "10.1089/ars.2017.7295",
language = "English",
volume = "29",
pages = "846--863",
journal = "Antioxidants and Redox Signaling",
issn = "1523-0864",
publisher = "Mary Ann Liebert Inc.",
number = "9",

}

RIS

TY - JOUR

T1 - Adenosine-to-Inosine RNA Editing in Health and Disease

AU - Gatsiou, Aikaterini

AU - Vlachogiannis, Nikolaos

AU - Lunella, Federica Francesca

AU - Sachse, Marco

AU - Stellos, Konstantinos

PY - 2018/9/20

Y1 - 2018/9/20

N2 - SIGNIFICANCE: Adenosine deamination in transcriptome results in the formation of inosine, a process that is called A-to-I RNA editing. Adenosine deamination is one of the more than 140 described RNA modifications. A-to-I RNA editing is catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes and is essential for life. Recent Advances: Accumulating evidence supports a critical role of RNA editing in all aspects of RNA metabolism, including mRNA stability, splicing, nuclear export, and localization, as well as in recoding of proteins. These advances have significantly enhanced the understanding of mechanisms involved in development and in homeostasis. Furthermore, recent studies have indicated that RNA editing may be critically involved in cancer, aging, neurological, autoimmune, or cardiovascular diseases.CRITICAL ISSUES: This review summarizes recent and significant achievements in the field of A-to-I RNA editing and discusses the importance and translational value of this RNA modification for gene expression, cellular, and organ function, as well as for disease development.FUTURE DIRECTIONS: Elucidation of the exact RNA editing-dependent mechanisms in a single-nucleotide level may pave the path toward the development of novel therapeutic strategies focusing on modulation of ADAR function in the disease context. Antioxid. Redox Signal. 29, 846-863.

AB - SIGNIFICANCE: Adenosine deamination in transcriptome results in the formation of inosine, a process that is called A-to-I RNA editing. Adenosine deamination is one of the more than 140 described RNA modifications. A-to-I RNA editing is catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes and is essential for life. Recent Advances: Accumulating evidence supports a critical role of RNA editing in all aspects of RNA metabolism, including mRNA stability, splicing, nuclear export, and localization, as well as in recoding of proteins. These advances have significantly enhanced the understanding of mechanisms involved in development and in homeostasis. Furthermore, recent studies have indicated that RNA editing may be critically involved in cancer, aging, neurological, autoimmune, or cardiovascular diseases.CRITICAL ISSUES: This review summarizes recent and significant achievements in the field of A-to-I RNA editing and discusses the importance and translational value of this RNA modification for gene expression, cellular, and organ function, as well as for disease development.FUTURE DIRECTIONS: Elucidation of the exact RNA editing-dependent mechanisms in a single-nucleotide level may pave the path toward the development of novel therapeutic strategies focusing on modulation of ADAR function in the disease context. Antioxid. Redox Signal. 29, 846-863.

KW - Adenosine/genetics

KW - Animals

KW - Deamination

KW - Disease/genetics

KW - Homeostasis/genetics

KW - Humans

KW - Inosine/genetics

KW - RNA/genetics

KW - RNA Editing/genetics

U2 - 10.1089/ars.2017.7295

DO - 10.1089/ars.2017.7295

M3 - Review article

C2 - 28762759

VL - 29

SP - 846

EP - 863

JO - Antioxidants and Redox Signaling

JF - Antioxidants and Redox Signaling

SN - 1523-0864

IS - 9

ER -