Research output: Contribution to conference - Without ISBN/ISSN › Conference paper › peer-review
Research output: Contribution to conference - Without ISBN/ISSN › Conference paper › peer-review
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TY - CONF
T1 - Advanced solid state NMR techniques for the investigation of the organic-mineral interfaces in biomaterials
T2 - 2009 MRS Fall Meeting
AU - Laurencin, D.
AU - Guerrero, G.
AU - Amalric, J.
AU - Bonhomme, C.
AU - Gervais, C.
AU - Smith, M.E.
AU - Mutin, P.H.
PY - 2010
Y1 - 2010
N2 - High resolution solid state NMR experiments were carried out on several compounds, to see how this technique can now be used to investigate in detail the surface structure of different biomaterials. First, because the surface of titanium implants can be functionalized by phosphonic acids, for instance to prevent bacterial adhesion, 17O NMR experiments were performed on model TiO2 surfaces functionalized by 17O enriched phosphonic acids, to look at the mode of grafting of these coupling agents. Results bring clear evidence of the formation of Ti-O-P bridges and of the presence of residual P=O and P-OH groups. Second, given that calcium phosphates are widely present in biological hard tissues and synthetic biomaterials, 43Ca correlation experiments were performed on Ca enriched materials (hydroxyapatite and calcium benzoate), to see how the proximities between this nucleus and neighbouring atoms can be analyzed. Results show that both Ca...C and Ca...H proximities can be evidenced, and could thus help elucidate interface structures. All in all, these studies should pave the way to future investigations of biomaterials, and in particular of the structure of organic-inorganic interfaces. © 2010 Materials Research Society.
AB - High resolution solid state NMR experiments were carried out on several compounds, to see how this technique can now be used to investigate in detail the surface structure of different biomaterials. First, because the surface of titanium implants can be functionalized by phosphonic acids, for instance to prevent bacterial adhesion, 17O NMR experiments were performed on model TiO2 surfaces functionalized by 17O enriched phosphonic acids, to look at the mode of grafting of these coupling agents. Results bring clear evidence of the formation of Ti-O-P bridges and of the presence of residual P=O and P-OH groups. Second, given that calcium phosphates are widely present in biological hard tissues and synthetic biomaterials, 43Ca correlation experiments were performed on Ca enriched materials (hydroxyapatite and calcium benzoate), to see how the proximities between this nucleus and neighbouring atoms can be analyzed. Results show that both Ca...C and Ca...H proximities can be evidenced, and could thus help elucidate interface structures. All in all, these studies should pave the way to future investigations of biomaterials, and in particular of the structure of organic-inorganic interfaces. © 2010 Materials Research Society.
KW - Bacterial adhesion
KW - Calcium benzoate
KW - Functionalized
KW - Hard tissues
KW - High-resolution solid state NMR
KW - Interface structures
KW - OH group
KW - Organic-inorganic interface
KW - Phosphonic acids
KW - Solid state NMR
KW - Synthetic biomaterials
KW - TiO
KW - Titanium implants
KW - Biological materials
KW - Biomaterials
KW - Calcium
KW - Calcium phosphate
KW - Coupling agents
KW - Hydroxyapatite
KW - Light polarization
KW - Nuclear magnetic resonance spectroscopy
KW - Organic acids
KW - Surface structure
KW - Titanium
KW - Experiments
U2 - 10.1557/PROC-1236-SS08-02
DO - 10.1557/PROC-1236-SS08-02
M3 - Conference paper
SP - 40
EP - 45
ER -