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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - African trypanosomes.
AU - Cayla, M
AU - Rojas Martinez, Federico
AU - Silvester, Eleanor
AU - Venter, Frank
AU - Matthews, Keith R.
PY - 2019/4/29
Y1 - 2019/4/29
N2 - African trypanosomes cause human African trypanosomiasis and animal African trypanosomiasis. They are transmitted by tsetse flies in sub-Saharan Africa. Although most famous for their mechanisms of immune evasion by antigenic variation, there have been recent important studies that illuminate important aspects of the biology of these parasites both in their mammalian host and during passage through their tsetse fly vector. This Primer overviews current research themes focused on these parasites and discusses how these biological insights and the development of new technologies to interrogate gene function are being used in the search for new approaches to control the parasite. The new insights into the biology of trypanosomes in their host and vector highlight that we are in a 'golden age' of discovery for these fascinating parasites.
AB - African trypanosomes cause human African trypanosomiasis and animal African trypanosomiasis. They are transmitted by tsetse flies in sub-Saharan Africa. Although most famous for their mechanisms of immune evasion by antigenic variation, there have been recent important studies that illuminate important aspects of the biology of these parasites both in their mammalian host and during passage through their tsetse fly vector. This Primer overviews current research themes focused on these parasites and discusses how these biological insights and the development of new technologies to interrogate gene function are being used in the search for new approaches to control the parasite. The new insights into the biology of trypanosomes in their host and vector highlight that we are in a 'golden age' of discovery for these fascinating parasites.
KW - Africa South of the Sahara/epidemiology
KW - Animals
KW - Host-Parasite Interactions
KW - Humans
KW - Insect Vectors/parasitology
KW - Trypanosoma brucei brucei/genetics
KW - Trypanosoma/classification
KW - Trypanosomiasis, African/epidemiology
KW - Tsetse Flies/parasitology
U2 - 10.1186/s13071-019-3355-5
DO - 10.1186/s13071-019-3355-5
M3 - Journal article
C2 - 31036044
VL - 12
JO - Parasites & vectors
JF - Parasites & vectors
IS - 1
M1 - 190
ER -