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Age at first birth in women is genetically associated with increased risk of schizophrenia

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Age at first birth in women is genetically associated with increased risk of schizophrenia. / Schizophrenia Working Group of the Psychiatric Genomics Consortium.
In: Scientific Reports, Vol. 8, No. 1, 10168, 05.07.2018.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Schizophrenia Working Group of the Psychiatric Genomics Consortium 2018, 'Age at first birth in women is genetically associated with increased risk of schizophrenia', Scientific Reports, vol. 8, no. 1, 10168. https://doi.org/10.1038/s41598-018-28160-z

APA

Schizophrenia Working Group of the Psychiatric Genomics Consortium (2018). Age at first birth in women is genetically associated with increased risk of schizophrenia. Scientific Reports, 8(1), Article 10168. https://doi.org/10.1038/s41598-018-28160-z

Vancouver

Schizophrenia Working Group of the Psychiatric Genomics Consortium. Age at first birth in women is genetically associated with increased risk of schizophrenia. Scientific Reports. 2018 Jul 5;8(1):10168. doi: 10.1038/s41598-018-28160-z

Author

Schizophrenia Working Group of the Psychiatric Genomics Consortium. / Age at first birth in women is genetically associated with increased risk of schizophrenia. In: Scientific Reports. 2018 ; Vol. 8, No. 1.

Bibtex

@article{2a2fb495132e42fdb7c99e280fa5c552,
title = "Age at first birth in women is genetically associated with increased risk of schizophrenia",
abstract = "Previous studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth in women (AFB). Here, we use independent data from the UK Biobank (N = 38,892) to replicate the finding of an association between predicted genetic risk of schizophrenia and AFB in women, and to estimate the genetic correlation between schizophrenia and AFB in women stratified into younger and older groups. We find evidence for an association between predicted genetic risk of schizophrenia and AFB in women (P-value = 1.12E-05), and we show genetic heterogeneity between younger and older AFB groups (P-value = 3.45E-03). The genetic correlation between schizophrenia and AFB in the younger AFB group is -0.16 (SE = 0.04) while that between schizophrenia and AFB in the older AFB group is 0.14 (SE = 0.08). Our results suggest that early, and perhaps also late, age at first birth in women is associated with increased genetic risk for schizophrenia in the UK Biobank sample. These findings contribute new insights into factors contributing to the complex bio-social risk architecture underpinning the association between parental age and offspring mental health.",
author = "Guiyan Ni and Jacob Gratten and Wray, {Naomi R} and Lee, {Sang Hong} and Jo Knight and {Schizophrenia Working Group of the Psychiatric Genomics Consortium}",
year = "2018",
month = jul,
day = "5",
doi = "10.1038/s41598-018-28160-z",
language = "English",
volume = "8",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Age at first birth in women is genetically associated with increased risk of schizophrenia

AU - Ni, Guiyan

AU - Gratten, Jacob

AU - Wray, Naomi R

AU - Lee, Sang Hong

AU - Knight, Jo

AU - Schizophrenia Working Group of the Psychiatric Genomics Consortium

PY - 2018/7/5

Y1 - 2018/7/5

N2 - Previous studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth in women (AFB). Here, we use independent data from the UK Biobank (N = 38,892) to replicate the finding of an association between predicted genetic risk of schizophrenia and AFB in women, and to estimate the genetic correlation between schizophrenia and AFB in women stratified into younger and older groups. We find evidence for an association between predicted genetic risk of schizophrenia and AFB in women (P-value = 1.12E-05), and we show genetic heterogeneity between younger and older AFB groups (P-value = 3.45E-03). The genetic correlation between schizophrenia and AFB in the younger AFB group is -0.16 (SE = 0.04) while that between schizophrenia and AFB in the older AFB group is 0.14 (SE = 0.08). Our results suggest that early, and perhaps also late, age at first birth in women is associated with increased genetic risk for schizophrenia in the UK Biobank sample. These findings contribute new insights into factors contributing to the complex bio-social risk architecture underpinning the association between parental age and offspring mental health.

AB - Previous studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth in women (AFB). Here, we use independent data from the UK Biobank (N = 38,892) to replicate the finding of an association between predicted genetic risk of schizophrenia and AFB in women, and to estimate the genetic correlation between schizophrenia and AFB in women stratified into younger and older groups. We find evidence for an association between predicted genetic risk of schizophrenia and AFB in women (P-value = 1.12E-05), and we show genetic heterogeneity between younger and older AFB groups (P-value = 3.45E-03). The genetic correlation between schizophrenia and AFB in the younger AFB group is -0.16 (SE = 0.04) while that between schizophrenia and AFB in the older AFB group is 0.14 (SE = 0.08). Our results suggest that early, and perhaps also late, age at first birth in women is associated with increased genetic risk for schizophrenia in the UK Biobank sample. These findings contribute new insights into factors contributing to the complex bio-social risk architecture underpinning the association between parental age and offspring mental health.

U2 - 10.1038/s41598-018-28160-z

DO - 10.1038/s41598-018-28160-z

M3 - Journal article

C2 - 29977057

VL - 8

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 10168

ER -